6-Aminothiouracil

Product Name: 6-Aminothiouracil
CAS No.: 1004-40-6
Chemical Name: 6-Aminothiouracil
Synonyms: AB 48;NSC 1587;NSC 202018;NSC 321193;NSC 321194;AURORA 13795;6-Aminothiouracil;4-Amino-2-thiouracil;6-AMINO-2-THIOURACIL;6-amino-2-thio-uraci
CBNumber: CB6730983
Molecular Formula: C4H5N3OS
Formula Weight: 143.17
MOL File: 1004-40-6.mol

More

Less

6-Aminothiouracil Property

Melting point:: >300?C (dec.)
Boiling point:: 246.5°C
Density: 1.397 (estimate)
refractive index: 1.7490 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: crystalline solid
pka: 7.92±0.20(Predicted)
color: Off-white
Water Solubility: 256.3mg/L(25 ºC)
InChI: InChI=1S/C4H5N3OS/c5-2-1-3(8)7-4(9)6-2/h1H,(H4,5,6,7,8,9)
InChIKey: YFYYRKDBDBILSD-UHFFFAOYSA-N
SMILES: C1(=S)NC(N)=CC(=O)N1
CAS DataBase Reference: 1004-40-6(CAS DataBase Reference)
NIST Chemistry Reference: Uracil, 6-amino-2-thio-(1004-40-6)
EPA Substance Registry System: 6-Amino-2-thiouracil (1004-40-6)

More

Less

Safety

Hazard Codes: Xi
RTECS: UW0495000
HS Code: 2933599590
Toxicity: LD50 ipr-mus: 370 mg/kg ARZNAD 31,1713,81

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: A0791
Product name: 4-Amino-6-hydroxy-2-mercaptopyrimidine
Packaging: 25G
Price: $29
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FA11937
Product name: 6-Amino-4-hydroxy-2-mercaptopyrimidine
Packaging: 25g
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 7175AF
Product name: 4-Amino-6-hydroxy-2-mercaptopyrimidine
Packaging: 1g
Price: $63
Updated: 2021/12/16

AK Scientific

Product number: 3276AH
Product name: 4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate
Packaging: 1g
Price: $63
Updated: 2021/12/16

Matrix Scientific

Product number: 073337
Product name: 6-Amino-4-hydroxy-2-mercaptopyrimidine
Purity: 95+%
Packaging: 1g
Price: $68
Updated: 2021/12/16

More

Less

6-Aminothiouracil Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

LAbelled derivative of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Synthesis

17356-08-0

105-56-6

1004-40-6

General procedure for the synthesis of 6-amino-2-thiouracil from the compound (CAS: 17356-08-0) and ethyl cyanoacetate: 101.5 g (1.88 mol) of sodium methanol was accurately weighed in a reaction flask containing 3 L of 670 g ethanol at room temperature. Subsequently, 67.3 g (0.88 mol) of thiourea was added and stirred until complete dissolution. The reaction mixture was heated to 55 °C and then 100 g (0.884 mol) of ethyl cyanoacetate was slowly added. The heating was continued to reflux and the reflux reaction was maintained for 4.5 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was cooled to 15 °C. The reaction mixture was filtered and the filter cake was washed once with 170 g ethanol. The washed filter cake was transferred to a 3 L reaction flask and appropriate amount of water was added, followed by 1.3 kg of water and stirred until complete dissolution. The pH of the solution was adjusted to 4 by slowly adding acetic acid at 20 °C, at which point a large amount of solid precipitated. The solid product was collected by filtration using a suction filter. The filter cake was dried at 45 °C overnight to give a final product of 115.4 g of 6-amino-2-thiouracil in 91.7% yield.

References

[1] Patent: CN106008633, 2016, A. Location in patent: Paragraph 0065; 0066; 0067; 0068
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 662 - 668
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4612 - 4621
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 18, p. 3389 - 3395
[5] Australian Journal of Chemistry, 2007, vol. 60, # 2, p. 120 - 123

6-Aminothiouracil Preparation Products And Raw materials

Raw materials

Ethanol Sodium Ethyl cyanoacetate Thiourea

Preparation Products

4,5-Diamino-6-hydroxypyrimidine 6-Mercaptopurine 6-Hydroxypurine 6-AMINO-5-BROMO-2-(ETHYLTHIO)PYRIMIDIN-4-OL

More

Less

6-Aminothiouracil Suppliers

Austria 1 Canada 2 China 153 Europe 1 Germany 3 India 3 South Korea 1 Ukraine 2 United Kingdom 13 United States 28 Global 207

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Alfa Chemistry

Tel: +1-5166625404;
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 20405
Advantage: 58

RR Scientific LLC

Tel: +86-13917743231
Email: sales@rrscientific.com
Country: United States
ProdList: 878
Advantage: 58

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3343
Advantage: 50

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Anisyn, Inc.

Tel: --
Fax: --
Email: sales@anisyn.com
Country: United States
ProdList: 863
Advantage: 0

Precursor Chemicals, Inc.

Tel: --
Fax: --
Email: info@precursorchem.com
Country: United States
ProdList: 347
Advantage: 51

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

Ryan Scientific, Inc.

Tel: --
Fax: --
Email: ryan.reichlyn@ryansci.com
Country: United States
ProdList: 6439
Advantage: 60

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Princeton BioMolecular Research, Inc.

Tel: --
Fax: --
Email: info@princetonbio.com
Country: United States
ProdList: 6934
Advantage: 51

City Chemicals Corporation

Tel: --
Fax: --
Country: United States
ProdList: 6460
Advantage: 72

George Uhe Co., Inc.

Tel: --
Fax: --
Email: global@uhe.com
Country: United States
ProdList: 520
Advantage: 65

HW Sands Corp.

Tel: --
Fax: --
Email: customerservice@hwsands.com
Country: United States
ProdList: 674
Advantage: 60

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

Pfaltz & Bauer, Inc.

Tel: --
Fax: --
Email: sales@pfaltzandbauer.com
Country: United States
ProdList: 6828
Advantage: 72

More

Less

View Lastest Price from 6-Aminothiouracil manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Aminothiouracil 1004-40-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Career Henan Chemical Co

Product: 6-Aminothiouracil 1004-40-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-11

1004-40-6, 6-AminothiouracilRelated Search:

2-Ethylhexyl mercaptoacetate 4-Aminopyrimidine 2-Aminopyrimidine Sodium thioglycolate 3-Mercaptopropionic acid 6-Mercaptopurine Calcium thioglycolate Acetaminophen Mercaptoacetic acid Glycine Diethylaminosulfur trifluoride 6-Aminocaproic acid 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL 1-PHENYL-2-THIOUREA POTASSIUM THIOGLYCOLATE 4-Hydroxy-6-aminopyrimidine 2-Aminophenol Tris(hydroxymethyl)aminomethane

4-Amino-2-thiouracil

4-AMINO-6-HYDROXY-2-MERCAPTOPYRIMIDINE

AURORA 13795

OTAVA-BB BB7013910011

6-AMINO-2-THIOXO-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE

6-AMINO-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE

6-Aminothiouracil

6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinone

2-Mercapto-6-aminouracil

2-MERCAPTO-4-HYDROXY-6-AMINO-PYRIMIDINE

6-AMINO-4-KETO-2-THIOPYRIMIDINE

6-Amino-2-sulfanylidene-1H-pyrimidin-4-one

6-AMINO-2-THIOURACIL

4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo- (9CI)

4-Amino-2-mercaptouracil

NSC 1587

NSC 202018

NSC 321193

NSC 321194

6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one 97%

6-Amino-2-thiouracil, 4-Amino-6-hydroxypyrimidine-2-thiol

6-Amino-2,3-dihydro-2-thioxo-1H-pyrimidin-4-one

6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one

4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo-

6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinon

6-amino-2-thio-uraci

6-Amino-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

AB 48

Pyrimidin-4-ol, 6-amino-2-mercapto-

6-Amino-2-mercapto-pyrimidin-4-ol ,97%

2-Thioxo-6-amino-1,2-dihydropyrimidine-4(3H)-one

6-Amino-2-mercaptopyrimidin-4(1H)-one

6-Amino-2-thioxo-1,2-dihydropyrimidine-4(3H)-one

4-Amino-2-thiouracil Discontinued See: A630455

4-amino-6-hydroxy-2-thiopyrimidine

6-Amino-2-mercapto-pyrimidin-4-ol ,98%

2-thio-6-aminouracil

1004-40-6

C4H5N3OS

Heterocycle-Pyrimidine series

Chemical Amines

Bases & Related Reagents

Heterocycles

Nucleotides

Sulfur & Selenium Compounds

Imidazoles & Benzimidazoles

Pyrazines, Pyrimidines & Pyridazines

PYRIMIDINE

Pyridines, Pyrimidines, Purines and Pteredines

Amines

Pyrazines, Pyrimidines & Pyridazines

Imidazoles & Benzimidazoles