Description References
ChemicalBook > CAS DataBase List > 4-Bromotoluene

4-Bromotoluene

Description References
Product Name
4-Bromotoluene
CAS No.
106-38-7
Chemical Name
4-Bromotoluene
Synonyms
1-BROMO-4-METHYLBENZENE;P-BROMOTOLUENE;PARA BROMO TOLUENE;1-Brom-4-methylbenzol;uene;ai328596;4-BromotoL;4-Bromtoluol;p-Tolybromide;p-bromo-toluen
CBNumber
CB6731117
Molecular Formula
C7H7Br
Formula Weight
171.03
MOL File
106-38-7.mol
More
Less

4-Bromotoluene Property

Melting point:
26-29 °C(lit.)
Boiling point:
184 °C(lit.)
Density 
1.39 g/mL at 25 °C(lit.)
refractive index 
1.549
Flash point:
185 °F
storage temp. 
Store below +30°C.
solubility 
0.11g/l insoluble
form 
Crystalline Low Melting Mass
Specific Gravity
1.390
color 
White
Water Solubility 
<0.1 g/100 mL at 24 ºC
Merck 
14,1439
BRN 
1903636
Dielectric constant
5.5（58.0℃）
CAS DataBase Reference
106-38-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-bromo-4-methyl-(106-38-7)
EPA Substance Registry System
p-Bromotoluene (106-38-7)
More
Less

Safety

Hazard Codes 
Xn,N,T
Risk Statements 
22-38-51/53-36/37/38
Safety Statements 
28-61-37/39-26
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
XS7965600
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29036990
Hazardous Substances Data
106-38-7(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H332Harmful if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B82200
Product name
4-Bromotoluene
Purity
98%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
B82200
Product name
4-Bromotoluene
Purity
98%
Packaging
100g
Price
$57.2
Updated
2024/03/01
TCI Chemical
Product number
B0661
Product name
4-Bromotoluene
Purity
>99.0%(GC)
Packaging
25g
Price
$39
Updated
2024/03/01
TCI Chemical
Product number
B0661
Product name
4-Bromotoluene
Purity
>99.0%(GC)
Packaging
100g
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
A15843
Product name
4-Bromotoluene, 98%
Packaging
25g
Price
$26.65
Updated
2024/03/01
More
Less

4-Bromotoluene Chemical Properties,Usage,Production

Description

4-Bromotoluene is a p-substituted aryl bromide. As a toluene derivative, it is used as a solvent and starting material for organic synthesis and is found in paints, paint thinners, glues, and other products. 4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. It is also used in manufacturing pharmaceuticals (especially for antihypertensive like losartan, Irbesartan), pesticides and other organic compounds1-3.

References

  1. https://www.sigmaaldrich.com/catalog/search?term=4-Bromotoluene&interface=All&N=0&mode=match%20partialmax&lang=en&region=US&focus=product
  2. https://bbzfrankie.wordpress.com/2013/11/21/application-of-4-bromotoluene/
  3. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+6015

Chemical Properties

white crystalline low melting mass, soluble in ethanol, ether and benzene, insoluble in water. toxic, harmful if swallowed, irritating to eyes, respiratory system and skin. 4-bromotoluene is a raw material of organic synthesis, which can be used as the manufacture of p-bromobenzyl, p-bromodibromobenzyl and p-bromobenzaldehyde, etc.

Uses

4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. 4-Bromotoluene undergoes Heck reaction with styrene in the presence of in situ generated palladium complexes of phosphine-functionalized N-heterocyclic carbene ligands.

Preparation

4-Bromotoluene is prepared by diazotization and replacement of p-toluidine. First, add aqueous sulfuric acid solution to crushed p-toluidine while hot, cool to 5°C, and slowly add aqueous sodium nitrite solution until the starch potassium iodide test paper turns blue. Then add a small amount of urea to destroy the excess of sodium nitrite. Then add the synthesized cuprous bromide to hydrobromic acid, heat it to boiling, then slowly add the above diazo salt and distill it until no oil-like substance comes out. Wash, dry, filter, distill at atmospheric pressure and collect 183-185℃ fraction to obtain 4-Bromotoluene.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 1, p. 136, 1941
Tetrahedron, 64, p. 4999, 2008 DOI: 10.1016/j.tet.2008.03.085

General Description

Crystals, clear pale yellow liquid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Bromotoluene is incompatible with strong oxidizing agents.

Fire Hazard

4-Bromotoluene is combustible.

Safety Profile

Moderately toxic by inhalation and intraperitoneal routes. When heated to decomposition it emits toxic vapors of Br-.

Purification Methods

Crystallise it from EtOH [Taylor & Stewart J Am Chem Soc 108 6977 1986]. [Beilstein 5 IV 827.]

4-Bromotoluene Preparation Products And Raw materials

Raw materials

PotassiuM iodide starch pa Sodium molybdate dihydrate Sodium bromide Copper shavings Cuprous bromide Copper(II) sulfate p-Toluidine

Preparation Products

(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL BIS(P-TOLYL)PHOSPHINE OXIDE 4-((N,N-DIMETHYLAMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER HYDROCHLORIDE 4-Bromobenzoic acid (S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97% TRI-P-TOLYLPHOSPHINE (R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE (4-PHENYLAMINOCARBONYLPHENYL)BORONIC ACID 2-(4-Methylphenyl)pyridine 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl TERT-BUTYL 4-(4-FORMYLBENZYL)PIPERAZINE-1-CARBOXYLATE (R)-(+)-TolBINAP 4-Bromobenzyl bromide 4-Bromobenzaldehyde 4-(METHOXYCARBONYL)PHENYLBORONIC ACID 4-N-BUTYLTOLUENE 3-(4-METHYLPHENYL)BENZALDEHYDE
More
Less

4-Bromotoluene Suppliers

Americas 1 Belgium 2 Canada 3 China 284 Cyprus 1 Europe 4 Germany 8 India 72 Israel 3 Italy 1 Japan 8 Russia 1 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 17 United States 49 Global 463
Dalian Zhuorui Biological Technology Co. LTD
Tel
13609862298
Email
yy7242701@163.com
Country
China
ProdList
77
Advantage
58
Qingdao Dexin Chemical Co., Ltd
Tel
18353358123 18353358123
Email
839877395@qq.com
Country
China
ProdList
176
Advantage
58
Wuxi South Chemical Additives Co., Ltd
Tel
18261593783
Email
3389909296@qq.com
Country
China
ProdList
31
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2963
Advantage
65
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
shanghai science Bio-Pharmceutical.co,ltd.
Tel
021-021-57872719 13761402923
Fax
02157872719
Email
245662540@qq.com
Country
China
ProdList
309
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Springchem New Material Technology Co.,Limited
Tel
+86-021-62885108 +8613917661608
Email
info@spring-chem.com
Country
China
ProdList
2068
Advantage
57
Yancheng Longshen Chemical Co.,Ltd.
Tel
0515-0515-88718898 18352070236
Fax
0515-88718898
Email
wendy@longshenchem.com
Country
China
ProdList
103
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Yurui (Shanghai) Chemical Co., Ltd.
Tel
21-50456736 13818239876
Fax
021-50761379
Email
sales21@riyngroup.com
Country
China
ProdList
1052
Advantage
30
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Simagchem Corp.
Tel
86 592 2680277
Fax
0086 592 2680237
Email
sale@simagchem.com
Country
China
ProdList
430
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2546
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2666
Advantage
55
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2656
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
More
Less

View Lastest Price from 4-Bromotoluene manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
4-Bromotoluene 106-38-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-13
Hebei Yanxi Chemical Co., Ltd.
Product
4-Bromotoluene 106-38-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-13
Hebei Yanxi Chemical Co., Ltd.
Product
4-Bromotoluene 106-38-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-13

106-38-7, 4-BromotolueneRelated Search:

Allyl bromide METSULFURON METHYL Bromobenzene 3,5-Dibromotoluene Methyl salicylate p-Toluenesulfonic acid BENZAL BROMIDE Tosyl chloride Thiophanate-methyl Tribenuron methyl 4-Chlorotoluene Kresoxim-methyl Xylene Dimidium bromide p-Toluenesulfonamide Sodium bromate Rocuronium bromide o-Xylene

  • 1-Brom-4-methylbenzol
  • 1-bromo-4-methyl-benzen
  • 1-Methyl-4-bromobenzene
  • ai328596
  • benzene,1-bromo-4-methyl-
  • p-bromo-toluen
  • p-Tolybromide
  • Toluene, p-bromo-
  • toluene,4-bromo-
  • Toluene,p-bromo-
  • 4-BROMO-1-METHYLBENZENE
  • 4-BROMOTOLUENE
  • The broMine toluene
  • 4-BromotoL
  • uene
  • 4-Bromo-1-methybezene
  • 4-bromo-toluen
  • 4-Bromtoluol
  • 4-Methylbromobenzene
  • 4-Methylphenyl bromide
  • 4-methylphenylbromide
  • 4-tolylbromide
  • 4-Methyl-1-bromobenzene
  • p-Bromo Toluene 4-Bromo Toluene
  • 4-BroMotoluene, 99% 100ML
  • P-TOLYL BROMIDE
  • P-BROMOTOLUENE
  • PARA BROMO TOLUENE
  • p-methylphenyl bromide
  • p-Methylbromobenzene
  • AKOS BBS-00004360
  • 1-BROMO-4-METHYLBENZENE
  • 4-BROMOTOLUENE FOR SYNTHESIS 250 G
  • 4-BROMOTOLUENE FOR SYNTHESIS 100 G
  • 4-Bromotoluene &gt
  • 4-Bromotoluene ISO 9001：2015 REACH
  • 4-Bromotoluene extrapure, 99%
  • 4-Bromo Toluence
  • 4-BROMO TOLUENE / PARA BROMO TOLUENE
  • 4-BROMO TOLUENE / PARA BROMO TOLUENE (PBT)
  • 4-Bromotoluene 98% For Synthesis
  • 106-38-7
  • 106-37-8
  • BrC6H4CH3
  • Halogenated Hydrocarbons
  • Organic Building Blocks
  • ARYL HALIDE
  • Aryl
  • C7
  • Building Blocks
  • 4-Alkylbromobenzenes (Building Blocks for Liquid Crystals)
  • Building Blocks for Liquid Crystals
  • alkyl bromide
  • Building Blocks
  • Chemical Synthesis
  • Halogenated Hydrocarbons
  • Organic Building Blocks
  • Intermediates