Butyrylcholinesterase

ChemicalBook > CAS DataBase List > Butyrylcholinesterase

Butyrylcholinesterase

Product Name: Butyrylcholinesterase
CAS No.: 9001-08-5
Chemical Name: Butyrylcholinesterase
Synonyms: Protexia;BtChoEase;EC 3.1.1.8;EC: 3.1.1.8;IUB: 3.1.1.8;E.C. 3.1.1.9;CHOLINESTERASE;choline esterase;Cholinesterase II;Choline esterase II
CBNumber: CB6778613
Formula Weight: 0
MOL File: Mol file

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Butyrylcholinesterase Property

Melting point:: 177-178.1 °C(Solv: ligroine (8032-32-4))
storage temp.: -20°C
form: powder
color: light brown
biological source: equine serum
Water Solubility: H2O: soluble 10mg/mL
Merck: 13,2229
Specific Activity: ≥900units/mg protein
EPA Substance Registry System: Esterase, choline (9001-08-5)

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Safety

Hazard Codes: B
Safety Statements: 22-24/25
WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7512
Product name: Butyrylcholinesterase from equine serum
Purity: lyophilized powder, ≥10?units/mg protein
Packaging: 1200units
Price: $226
Updated: 2024/03/01

Sigma-Aldrich

Product number: C7512
Product name: Butyrylcholinesterase from equine serum
Purity: lyophilized powder, ≥10?units/mg protein
Packaging: 6000Units
Price: $474
Updated: 2024/03/01

Sigma-Aldrich

Product number: C7512
Product name: Butyrylcholinesterase from equine serum
Purity: lyophilized powder, ≥10?units/mg protein
Packaging: 12000units
Price: $1440
Updated: 2024/03/01

Sigma-Aldrich

Product number: C1057
Product name: Butyrylcholinesterase from equine serum
Purity: lyophilized powder, ≥900?units/mg protein
Packaging: 1000UNITS
Price: $446
Updated: 2023/06/20

Sigma-Aldrich

Product number: C4290
Product name: Butyrylcholinesterase from equine serum
Purity: lyophilized powder, ≥500?units/mg protein
Packaging: 1000UNITS
Price: $350
Updated: 2023/06/20

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Butyrylcholinesterase Chemical Properties,Usage,Production

Uses

Butyrylcholinesterase from equine serum has been used in a microcalorimetric study of the inhibition of butyrylcholinesterase by paraoxon. This enzyme has also been used in a study to investigate the synthesis and inhibition of cholinergic enzymes. Selective inhibition of BChE activity can be used in the detection of organophosphates. Its use in the treatment of organophosphate toxicity has shown clinical potential, as there is a correlation between the blood level of BChE in humans and the degree of protection against toxic nerve agents. There has also been an interest in the roles of cholinesterases with regard to Alzheimer′s disease. Investigations into selective inhibitors may provide a clearer picture of the physiological role of BChE in both healthy and diseased individuals. This product has been used for the screening of cholineesterase inhibitors in selected fruits and vegetables, for restoring cognitive function and improving memory. It has also been used to develop a butyrylcholinesterase and choline oxidase immobilized bio-sniffer for the detection of nicotine. Nicotine inhibits BChE activity. A decrease in the byproducts of BChE activity reflects the volume of nicotine.

Uses

Selective inhibition of BChE activity, Butyrylcholinesterase can be used in the detection of organophosphates.Its use in the treatment of organophosphate toxicity has been explored. It has been reported that the level of BChE in human blood correlates to the degree of protection against potentially toxic nerve agents.Cholinesterases have also been investigated for their role in Alzheimer’s disease.

Biological Functions

Butyrylcholinesterase (BuChE) is found in plasma, the liver, and the kidney. Its activity is also inhibited by carbamate insecticides. BuChE is able to hydrolyze much larger substrates than AChE due to differences in their structure that allow BuChE to bind bulky ligands. The physiological role of BuChE is not completely understood, but it represents an important detoxification pathway for anticholinesterase compounds (Sultatos, 2006).

General Description

Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). It is also termed as pseudocholinesterase. It is produced in the liver. It is found in blood, the synapse of neuromuscular junctions and glia cells and axons of white matter.

Biochem/physiol Actions

Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate.

Butyrylcholinesterase Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Butyrylcholinesterase manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: Butyrylcholinesterase 9001-08-5
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-06-30

9001-08-5, ButyrylcholinesteraseRelated Search:

Ferric acetylacetonate Tosylmethyl isocyanide COBALT(II) ACETYLACETONATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) TERT-BUTYL ISOCYANIDE METHYL ISOCYANOACETATE N-BUTYLISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Cupric acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE Ethyl isocyanoacetate Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL SALCOMINE

ACYLCHOLINE ACYL-HYDROLASE

BUTYRYL CHOLINESTERASE

BUTYRYLCHOLINE ESTERASE

IUB: 3.1.1.8

BUTYRYLCHOLINE ESTERASE FROM HORSE SERUM, ~250 U/MG*

CHOLINESTERASE BUTYRYL FROM HUMAN SERUM

BUTYRYLCHOLINESTERASE, HUMAN

BUTYRYLCHOLINE ESTERASE F. HORSE SERUM, LYOPH., ~10 U/MG

CHOLINESTERASE, BUTYRYL FROM HORSESERUM

BUTYRYL CHOLINESTERASE FROM EQUINE SERUM FROM EQUINE SERUM -20 °C

butyrylcholine esterase F. horse serum

butyrylcholine esterase from horse serum

Butyrylcholinesterase from equine serum

Cholinesterase, Equine Serum

BUTYRYL CHOLINESTERASE FROM HORSE SERUM 4-10 UNITS/MG DRY WEIGHT FROM HORSE SERUM

BUTYRYL CHOLINESTERASE FROM HORSE SERUM (ACYLCHOLINE ACYL-HYDROLASE E.C. 3.1.1.8) LYOPHILIZED 0 °C

BUTYRYL CHOLINESTERASE FROM HORSE SERUM LYOPHILIZED POWDER 0 °C

butyrylcholinesterase from human serum

Cholinesterase,from Horse Serum

Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase

choline esterase

Butyrylcholine esterase from equine serum, lyophil.

Cholinesterase,butyryl(Horse seruM)

Protexia

Esterase, butyrylcholine

E.C. 3.1.1.9

Cholinesterase II

Choline esterase II

BtChoEase

Benzoylcholinesterase

PSEUDOCHOLINEESTERASE

PSEUDOCHOLINESTERASE

EC 3.1.1.8

EC: 3.1.1.8

CHOLINESTERASE, BUTYRYL

CHOLINE ESTERASE, BUTYRYL

CHOLINESTERASE

Butyrylcholinesterase USP/EP/BP

Butyrylcholinesterase (EC 3.1.1.8) from horse serum

JCCRM 002(ChE) Cholinesterase

9001-08-5

General Metabolic Enzymes

General Metabolic Enzymes A-H

Enzymes, Inhibitors, and Substrates

Enzyme Class Index

3.1.x.x Acting on esters

3.x.x.x Hydrolases

Metabolomics

BioChemical

Biochemicals and Reagents

3.1.x.x Acting on esters

3.x.x.x Hydrolases

Enzyme Class Index