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ChemicalBook > CAS DataBase List > 5-BROMO-2-METHYLPYRIDIN-3-AMINE

5-BROMO-2-METHYLPYRIDIN-3-AMINE

Description Reference
Product Name
5-BROMO-2-METHYLPYRIDIN-3-AMINE
CAS No.
914358-73-9
Chemical Name
5-BROMO-2-METHYLPYRIDIN-3-AMINE
Synonyms
3-Amino-5-bromopicoline;3-Amino-5-bromo-2-methylp...;3-Amin-5-bromo-2-methylpyridine;5-bromo-2-methyl-3-Pyridinamine;5-BROMO-2-METHYLPYRIDIN-3-AMINE;2-Methyl-3-amino-5-bromopyridine;3-Amino-5-bromo-2-methylpyridine;5-Bromo-2-Methylpyridine-3-amine;3-pyridinaMine, 5-broMo-2-Methyl;5-BroMo-2-Methyl-pyridin-3-ylaMine
CBNumber
CB6818821
Molecular Formula
C6H7BrN2
Formula Weight
187.04
MOL File
914358-73-9.mol
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5-BROMO-2-METHYLPYRIDIN-3-AMINE Property

Melting point:
108-109℃
Boiling point:
283.5±35.0 °C(Predicted)
Density 
1.593±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
crystalline solid
pka
4.53±0.20(Predicted)
color 
Off-white
InChI
InChI=1S/C6H7BrN2/c1-4-6(8)2-5(7)3-9-4/h2-3H,8H2,1H3
InChIKey
CBAXYISWNGGXOZ-UHFFFAOYSA-N
SMILES
C1(C)=NC=C(Br)C=C1N
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Safety

Risk Statements 
41
Safety Statements 
26-39
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

SynQuest Laboratories
Product number
3H30-9-42
Product name
3-Amino-5-bromo-2-methylpyridine
Packaging
25g
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA55674
Product name
3-Amino-5-bromo-2-methylpyridine
Packaging
1g
Price
$209.4
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA55674
Product name
3-Amino-5-bromo-2-methylpyridine
Packaging
5G
Price
$535.9
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0028400
Product name
5-BROMO-2-METHYLPYRIDIN-3-AMINE
Purity
95.00%
Packaging
1G
Price
$652.58
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0028400
Product name
5-BROMO-2-METHYLPYRIDIN-3-AMINE
Purity
95.00%
Packaging
5G
Price
$979.44
Updated
2021/12/16
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5-BROMO-2-METHYLPYRIDIN-3-AMINE Chemical Properties,Usage,Production

Description

5-Bromo-2-methylpyridin-3-amine is also named as 3-Amino-5-bromo-2-methylpyridine. It can be converted to 5-bromo-2-methyl-3-pyridinol by diazotization with sodium nitrite in aqueous sulfuric acid. 5-Bromo-2-methyl-3-pyridinol can be used to make brominated dihydropyridines, which are substrates for the palladium catalyzed coupling, a process to produce compounds for the treatment of patients with disorders, such as central nervous system disorders.

Reference

G. Dull, J. Munoz, J. Genus, J. Moore, Hydroxybenzoate salts of metanicotine compounds, Patent US20060122239A1

Uses

3-Amino-5-bromo-2-methylpyridine (3ABMP) is a kind of biochemical reagent.

Synthesis

911434-05-4

914358-73-9

The general procedure for the synthesis of 2-methyl-3-amino-5-bromopyridine from 5-bromo-2-methyl-3-nitropyridine was as follows: 5-bromo-2-methyl-3-nitropyridine (13.8 g, 63.9 mmol) was dissolved in industrial methanol (330 mL) at 40 °C, followed by the addition of powdered iron (20 g) in batches to avoid agglomeration. Next, concentrated aqueous hydrochloric acid (5 mL) was added for elution. The resulting dark brown mixture was stirred vigorously under reflux conditions for 2 h. After completion of the reaction, it was cooled to room temperature and filtered through Celite (the filter cake was washed with 1 L of industrial methanol). The filtrate was concentrated under reduced pressure to remove the solvent, and the residue was dissolved in ethyl acetate (200 mL), the organic phase was washed with saturated aqueous sodium bicarbonate (200 mL), and dried with anhydrous magnesium sulfate. Finally, the solvent was removed under reduced pressure to afford the target product 5-bromo-2-methylpyridin-3-amine as an orange solid (10.7 g, 90% yield). The structure of the product was confirmed by 1HNMR (400 MHz, CDCl3, δ): 7.91 (s, 1H), 7.00 (s, 1H), 3.75 (br.s, 2H), 2.25 (s, 3H).

References

[1] Bergmeyer, et al. "Biochemical reagents." Methods of Enzymatic Analysis. Academic Press, 1965. 967-1037.

5-BROMO-2-METHYLPYRIDIN-3-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2-METHYLPYRIDIN-3-AMINE Suppliers

China 211 India 5 United Kingdom 3 United States 13 Global 232
Accela ChemBio Inc.
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+1(858) 699-3322
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+1(858) 876-1948
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marketing@accelachem.com
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Alchem Pharmtech,Inc.
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Synthonix Inc
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Matrix Scientific
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View Lastest Price from 5-BROMO-2-METHYLPYRIDIN-3-AMINE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-BROMO-2-METHYLPYRIDIN-3-AMINE 914358-73-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Fengda Chemical Co., Ltd
Product
5-BROMO-2-METHYLPYRIDIN-3-AMINE 914358-73-9
Price
US $6.00-0.20/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03
Shaanxi Dideu Medichem Co. Ltd
Product
5-bromo-2-methylpyridin-3-amine 914358-73-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2019-12-25

914358-73-9, 5-BROMO-2-METHYLPYRIDIN-3-AMINERelated Search:

5-AMINO-3-BROMO-2-METHOXYPYRIDINE 3-AMINO-5-BROMO-PYRIDIN-2-OL 3-AMINO-5-BROMO-2-METHOXYPYRIDINE 2-Bromo-6-methylpyridin-3-amine 6-Bromo-N-methylpyridin-2-amine 5-BROMO-6-METHYLPYRIDIN-2-AMINE 3-BROMO-5-METHYLPYRIDIN-2-AMINE 5-BROMO-3-METHYLPYRIDIN-2-AMINE,5-Bromo-3-methylpyridin-2-amine ,98% 5-Bromo-6-methylpyridin-3-amine 5-Bromo-2-methylpyridine 3-BROMO-6-METHYLPYRIDIN-2-AMINE 3-Bromo-5-methylpyridin-4-amine 2-BROMO-4-METHYLPYRIDIN-3-AMINE 5-Bromo-2-methylpyridin-4-amine 5-BROMO-N-METHYLPYRIDIN-2-AMINE 4-BROMO-6-METHYLPYRIDIN-2-AMINE 4-Amino-3-bromo-5-methylpyridine 6-BROMO-2-METHYLPYRIDIN-3-AMINE

  • 5-BROMO-2-METHYLPYRIDIN-3-AMINE
  • 5-bromo-2-methyl-3-Pyridinamine
  • 3-Amino-5-bromo-2-methylpyridine
  • 3-Amino-5-bromo-2-methylp...
  • 5-BroMo-2-Methyl-pyridin-3-ylaMine
  • 3-pyridinaMine, 5-broMo-2-Methyl
  • 3-Amino-5-bromopicoline
  • 5-Bromo-2-Methylpyridine-3-amine
  • 3-Amin-5-bromo-2-methylpyridine
  • 5-BROMO-2-METHYLPYRIDIN-3-AMINE ISO 9001：2015 REACH
  • 2-Methyl-3-amino-5-bromopyridine
  • 914358-73-9