Ethyl bromoacetate

Product Name: Ethyl bromoacetate
CAS No.: 105-36-2
Chemical Name: Ethyl bromoacetate
Synonyms: ETHYL 2-BROMOACETATE;BROMOACETIC ACID ETHYL ESTER;Antol;ethylbromacetate;hyl bromoacetate;Ethyl-bromacetat;Ethyl bromacetate;ETHYL BROMOACETATE;ethylbromoethanoate;bromoacetated’ethyle
CBNumber: CB6852654
Molecular Formula: C4H7BrO2
Formula Weight: 167
MOL File: 105-36-2.mol

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Ethyl bromoacetate Property

Melting point:: -38 °C
Boiling point:: 159 °C(lit.)
Density: 1.506 g/mL at 25 °C(lit.)
vapor density: 5.8 (vs air)
vapor pressure: 2.6 mm Hg ( 25 °C)
refractive index: n20/D 1.451(lit.)
Flash point:: 118 °F
storage temp.: Store below +30°C.
solubility: water: insoluble
form: Liquid
color: Clear
Specific Gravity: 1.506
Odor: Pungent odour
Water Solubility: Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water.
BRN: 506456
Dielectric constant: 9.75
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, water, strong acids.
InChIKey: PQJJJMRNHATNKG-UHFFFAOYSA-N
CAS DataBase Reference: 105-36-2(CAS DataBase Reference)
NIST Chemistry Reference: Acetic acid, bromo-, ethyl ester(105-36-2)
EPA Substance Registry System: Acetic acid, 2-bromo-, ethyl ester (105-36-2)

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 26-45-7/9-1/2
RIDADR: UN 1603 6.1/PG 2
WGK Germany: 1
RTECS: AF6000000
F: 19
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29159080
Hazardous Substances Data: 105-36-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.01636
Product name: Ethyl bromoacetate
Purity: for synthesis
Packaging: 250ML
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.01636
Product name: Ethyl bromoacetate
Purity: for synthesis
Packaging: 1L
Price: $351
Updated: 2024/03/01

Sigma-Aldrich

Product number: 133973
Product name: Ethyl bromoacetate
Purity: reagent grade, 98%
Packaging: 5g
Price: $42.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 133973
Product name: Ethyl bromoacetate
Purity: reagent grade, 98%
Packaging: 100g
Price: $42.6
Updated: 2024/03/01

Alfa Aesar

Product number: A10448
Product name: Ethyl bromoacetate, 98%
Packaging: 100g
Price: $39
Updated: 2024/03/01

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Ethyl bromoacetate Chemical Properties,Usage,Production

Description

Ethyl bromoacetate is a clear, colorless tolight-yellow liquid. Molecular weight = 167.02; Boilingpoint = 159℃. Freezing point ≤－20℃; Flashpoint = 48℃. Hazard Identification (based on NFPA-704 MRating System): Health 2, Flammability 2, Reactivity 0.Insoluble in water

Chemical Properties

Ethyl bromoacetate is a clear, colorless to light-yellow liquid and has a pungent odor. It is miscible with ethanol, ether, benzene and with other oxygenated and aromatic solvents, insoluble in water and partially decomposed by water.

Uses

Ethyl bromoacetate is widely used as an alkylating reagent involved in the Reformatsky reaction to prepare the beta-hydroxy esters by reacting with carbonyl compounds. It is also used for the syntheses of witting reagent, artificial diethylstilbestrol antigen, 3-phenyl-1-naphthol and steroidal thiazolidinone derivatives. It finds applications in the preparation of reversibly photoresponsive coumarin-stabilized polymeric nanoparticles in an aqueous medium which act as a detectable drug carrier.

Application

Ethyl Bromoacetate is used as a synthetic organic chemical intermediate as well as a pharmaceutical and agricultural intermediate. It is used in the synthesis of metabolites of carcinogenic PAHs. It is also used in the preparation of steroidal antiestrogens through cyclic condensation. Ethyl Bromoacetate is a reactant in the preparation of antim icrobial and antioxidant coumarinyloxymethyl-thiadiazolone.

Preparation

Ethyl bromoacetate is commonly synthesized by sulfuric acid catalyzed esterification of monobromoacetic acid (MBAA). After reaction completion, excess acid is washed out and the product purified via distillation under reduced pressure if necessary (Stenger, 1978; Korhonen, 1984).

Reactions

Ethyl bromoacetate on derivatisation reaction with p-t-butyl calix[4]arene yields 1,3-diester substituted calix[4]arene. It also undergoes Suzuki type cross-coupling reactions with arylboronic acids cocatalyzed by copper(I) oxide.

General Description

Ethyl bromoacetate appears as a clear, colorless liquid. A lachrymator. Toxic by ingestion, inhalation and skin absorption; a strong irritant of the skin. Insoluble in water and soluble in alcohol, benzene, and ether. Specific gravity of 1.5.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

Ethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Toxic by ingestion, inhalation, and skin absorption; strong irritant.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

A poison. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid when exposed to heat, flame, and oxidizers. Will react with water or steam to produce toxic and corrosive fumes. To fight fire, use water as a fire blanket. When heated to decomposition or on contact with acid or acid fumes, it emits highly toxic fumes of Br-. See also BROMIDES.

Potential Exposure

Used for making pharmaceuticals; as a warning gas in poisonous, odorless gasses; as a tear gas

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24- 48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a corticosteroid spray

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, well-ventilated area away from oxidizers, strong acids, strongbases, reducing agents, heat, and sources of ignition. Wherepossible, automatically pump liquid from drums or otherstorage containers to process containers.

Shipping

UN1603 Ethyl bromoacetate, Hazard class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beilstein 2 IV 527.] LACHRYMATORY.

Incompatibilities

Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition.

Ethyl bromoacetate Preparation Products And Raw materials

Raw materials

Bromoacetic acid

Preparation Products

ETHYL(5-BROMOBENZOFURAN)-2-CARBOXYLATE ETHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE 5-BROMO-1-BENZOFURAN-2-CARBALDEHYDE 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE ethyl 2-(2-aminothiazol-5-ylthio)acetate 3-METHYLBENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER 3-O-TOLYL-PROPIONALDEHYDE Ethyl 2-oxocyclopentylacetate 5-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID 2-Phenyl-1H-indole-1-acetic acid ,97% (R)-3-Aminoquinuclidine dihydrochloride 3,4-DIMETHYLTHIENO[2,3-B]THIOPHENE-2-CARBALDEHYDE (5-BROMO-1-BENZOFURAN-2-YL)METHANOL 3-(4-CHLORO-PHENYL)-PROPIONALDEHYDE 3,5-DIMETHYL-BENZOFURAN-2-CARBOXYLIC ACID 2-Piperazinone Rhodanine-3-acetic acid 3-CHLOROPHENOXYACETYL CHLORIDE ETHYL METHANESULFONYLACETATE 6-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID 4-(TRIFLUOROMETHYL)PHENOXYACETIC ACID (4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID METHYL5,5,5-TRIFLUORO-4-OXOPENTANOATE (4-PHENYL-PIPERAZIN-1-YL)-ACETIC ACID trans-2-Octen-1-ol 2-METHYLCYCLOPROPANECARBOXYLIC ACID MORPHOLINE-4-CARBOTHIOAMIDE (S)-(+)-3-Quinuclidinol Ethyl(4-butyry-2,3-dichloro)phenoxyacetate Ethyl 3,5-dimethylbenzofuran-2-carboxylate ,95% 4-CHLORO-8-FLUORO-5H-PYRIMIDO[5,4-B]INDOLE (4-FLUOROPHENOXY)ACETYL CHLORIDE 2-(CARBOXYMETHOXY)BENZOIC ACID ethyl 2-(2-phenyl-1H-indol-1-yl)acetate Ethyl 3,3-Diethoxypropionate 3-COUMARANONE ETHYL 2-(5-FORMYL-2,4-DIMETHYL-1H-PYRROL-3-YL)ACETATE quinuclidine-3-carboxylic acid GERANIC ACID (R)-3-Quinuclidinol hydrochloride

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View Lastest Price from Ethyl bromoacetate manufacturers

Hebei Miaoyin Technology Co.,Ltd

Product: ethyl 2-bromoacetate 105-36-2
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000
Release date: 2023-04-18

Hebei Yanxi Chemical Co., Ltd.

Product: Ethyl bromoacetate 105-36-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: Ethyl Bromoacetate 105-36-2
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-22

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Lumacaftor Impurity 8

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Ethyl Bromoacetate 95% For Synthesis

105-36-2

105-30-2

C4H7BrO2

BrCH2COOC2H5

BrCH2CO2CH2CH3

CH2BrCOOC2H5

Organic Building Blocks

Esters

ACETATE

C2 to C5

Carbonyl Compounds

Building Blocks

Esters

C2 to C5

Carbonyl Compounds

Pharmaceutical Intermediates

Organics