ChemicalBook > CAS DataBase List > Etofenamate

Etofenamate

Product Name
Etofenamate
CAS No.
30544-47-9
Chemical Name
Etofenamate
Synonyms
ReuMon;TV-485;Rheumon;TVX-485;CS-1431;Bayrogel;Etofenate;Etofenamate;TrauMon Gel;Ethofenamate
CBNumber
CB6883241
Molecular Formula
C18H18F3NO4
Formula Weight
369.33
MOL File
30544-47-9.mol
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Etofenamate Property

Melting point:
25°C
Boiling point:
bp.001 130-135°
Density 
1.2866 (estimate)
refractive index 
nD25 1.564
storage temp. 
Sealed in dry,2-8°C
solubility 
Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate.
pka
14.32±0.10(Predicted)
form 
Oil
color 
Light yellow to yellow
Stability:
Light Sensitive
InChI
InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2
InChIKey
XILVEPYQJIOVNB-UHFFFAOYSA-N
SMILES
C(OCCOCCO)(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1
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Safety

RIDADR 
UN2810 - class 6.1 - PG 3 - EHS - Toxic, liquids, organic, n.o.s., HI: all
Toxicity
LD50 in male, female rats (mg/kg): 292, 470 orally; 140, 226 i.v.; 373, 397 i.p.; 643, 568 s.c. (Jacobi)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E2499901
Product name
Etofenamate for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
20 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
E2499900
Product name
Etofenamate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
50 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
E2499901
Product name
Etofenamate for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
e2499901
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
E2499900
Product name
Etofenamate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
e2499900
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
E1551
Product name
Etofenamate
Purity
min. 98.0 %
Packaging
250MG
Price
$300
Updated
2025/07/31
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Etofenamate Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Oil

Originator

Rheumon,Troponwerke,W. Germany,1977

Uses

As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.

Definition

ChEBI: 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester.

Manufacturing Process

16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)- anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to 110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added. The reaction mixture is then heated to boiling for 2 hours. The precipitated potassium chloride is filtered off and the solvent is removed by evaporation. The residue is separated over a column with 400 g of silica gel (particle size 0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3- trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale yellow oil which does not crystallize and cannot be distilled.

Therapeutic Function

Antiinflammatory

Etofenamate Preparation Products And Raw materials

Raw materials

Preparation Products

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Etofenamate Suppliers

Canada 1 China 132 France 1 Germany 3 India 6 South Korea 1 Spain 2 United States 17 Global 163
Shaoxing Hongda Medical Technology Co.,Ltd
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View Lastest Price from Etofenamate manufacturers

Dideu Industries Group Limited
Product
Etofenamate 30544-47-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-15
Career Henan Chemical Co
Product
Etofenamate 30544-47-9
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

30544-47-9, EtofenamateRelated Search:

Etomidate 3-Diethylaminophenol Benzyl benzoate FLURBIPROFEN AXETIL Denatonium Benzoate Anhydrous Ethyl acetate 2'-Hydroxy-3-phenylpropiophenone 2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate Meclofenoxate hydrochloride Ethanol Phenetidine Sodium benzoate Ethyl acrylate Butylparaben Ethylparaben ISOXADIFEN-ETHYL 3-Hydroxybenzoic acid Salicylic acid

  • EtofenamateEtofenamate
  • 2-(2-hydroxyaethoxy)aethylester der flutenaminsaeure
  • 2-(2-hydroxyethoxy)ethyl-n-(alpha,alpha,alpha-trifluoro-m-tolyl)anthrani late
  • Benzoic acid, 2[[3-(trifluoromethyl)phenyl]amino]-2-(hydroxyethoxy)ethyl ester
  • n-(alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilic acid 2-(2-hydroxyethoxy)
  • 2-(2-Hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate
  • Ethofenamate
  • Rheumon
  • Etofenamate
  • 2-(2-Hydroxyethoxy)ethyl FufenaMate
  • 2-[[3-(TrifluoroMethyl)phenyl]aMino]benzoic Acid 2-(2-Hydroxyethoxy)ethyl Ester
  • Bayrogel
  • ReuMon
  • TrauMon Gel
  • 2-(2-hydroxyethoxy)ethyl 2-((3-(trifluoroMethyl)phenyl)aMino)benzoate
  • EtofenaMate,TV-485
  • TV-485
  • TVX-485
  • Etofenamate, >=98%
  • CS-1431
  • Etofenamate CRS
  • Etofenamate for peak identification CRS
  • Benzoic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 2-(2-hydroxyethoxy)ethyl ester
  • Etofenamate USP/EP/BP
  • Etofenate
  • Etofenamate, 10 mM in DMSO
  • 30544-47-9
  • Inhibitors
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals