2-AMINO-4-FLUOROPHENOL
Application- Product Name
- 2-AMINO-4-FLUOROPHENOL
- CAS No.
- 399-97-3
- Chemical Name
- 2-AMINO-4-FLUOROPHENOL
- Synonyms
- Aminofluorophenol1;2-AMINO-4-FLUOROPHEN;2-AMINO-4-FLUOROPHENOL;5-Fluoro-2-hydroxyaniline;Phenol, 2-amino-4-fluoro-;2-Amino-4-fluorophenol98%;2-Amino-4-fluorophenol >2-Amino-4-fluorophenol 98%;2- aMino-4-difluoro phenol;6007 2-AMINO-4-FLUORO PHENOL
- CBNumber
- CB7113996
- Molecular Formula
- C6H6FNO
- Formula Weight
- 127.12
- MOL File
- 399-97-3.mol
2-AMINO-4-FLUOROPHENOL Property
- Melting point:
- 130-135 °C
- Boiling point:
- 252.9±25.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 9.77±0.18(Predicted)
- color
- Light yellow to Brown
- InChI
- InChI=1S/C6H6FNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2
- InChIKey
- ULDFRPKVIZMKJG-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(F)C=C1N
- CAS DataBase Reference
- 399-97-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29222990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 683302
- Product name
- 2-Amino-4-fluorophenol
- Purity
- 96%
- Packaging
- 1g
- Price
- $67.54
- Updated
- 2025/07/31
- Product number
- A2400
- Product name
- 2-Amino-4-fluorophenol
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $395
- Updated
- 2025/07/31
- Product number
- A2400
- Product name
- 2-Amino-4-fluorophenol
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $1695
- Updated
- 2025/07/31
- Product number
- A634648
- Product name
- 2-Amino-4-fluorophenol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC5940
- Product name
- 2-Amino-4-fluorophenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2-AMINO-4-FLUOROPHENOL Chemical Properties,Usage,Production
Application
2-Amino-4-fluorophenol has wide applications in drug synthesis, serving as a synthetic intermediate for certain drugs. Furthermore, it possesses antibacterial and anti-inflammatory properties, making it useful in treating some infectious and inflammatory diseases.
Chemical Properties
White to brown solid
Synthesis
394-33-2
399-97-3
The general procedure for the synthesis of 2-amino-4-fluorophenol from 2-nitro-4-fluorophenol was as follows: tin(II) chloride (12.1 g, 63.6 mmol) was added to a solution of 4-fluoro-2-nitrophenol (2.00 g, 12.7 mmol) in ethanol (45 mL). The reaction mixture was heated to 70 °C and maintained at this temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water (~200 mL). After the mixture was warmed to room temperature, the pH was adjusted with 2N NaOH aqueous solution to about 9. The reaction mixture was filtered and the filtrate was extracted with ethyl acetate (3×). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the organic phase was concentrated under reduced pressure. 1.21 g (75% yield) of 2-amino-4-fluorophenol was finally obtained.Results of LC-MS analysis: retention time (RT) = 4.48 min, [M + H]+ = 128.0.
References
[1] Patent: EP1346982, 2003, A1
[2] Inorganic Chemistry, 2010, vol. 49, # 23, p. 11106 - 11117
[3] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 80
[4] Journal of Organic Chemistry, 1951, vol. 16, p. 1345,1348
[5] J. Gen. Chem. USSR (Engl. Transl.), 1975, vol. 45, p. 2372 - 2379
2-AMINO-4-FLUOROPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-4-FLUOROPHENOL Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 2-AMINO-4-FLUOROPHENOL manufacturers
- Product
- 2-Amino-4-fluorophenol 399-97-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000
- Release date
- 2024-06-19
- Product
- 2-Amino-4-fluorophenol 399-97-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 2-AMINO-4-FLUOROPHENOL 399-97-3
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10