1-N-Boc-3-Azetidinecarboxylic acid
- Product Name
- 1-N-Boc-3-Azetidinecarboxylic acid
- CAS No.
- 142253-55-2
- Chemical Name
- 1-N-Boc-3-Azetidinecarboxylic acid
- Synonyms
- 1-(TERT-BUTOXYCARBONYL)AZETIDINE-3-CARBOXYLIC ACID;AZETIDINE-1,3-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER;BOC-AZE(3)-OH;CAS:142253-55-2;RARECHEM BK PT 0278;Boc-3-Azetidinecarboxylic acid;BOC-AZETIDINE-3-CARBOXYLIC ACID;1-Boc-Azetidine3-Carboxylicacide;Boc-N-Azetidine-3-carboxylic acid;N-BOC-3-AZETIDINE CARBOXYLIC ACID
- CBNumber
- CB7123126
- Molecular Formula
- C9H15NO4
- Formula Weight
- 201.22
- MOL File
- 142253-55-2.mol
1-N-Boc-3-Azetidinecarboxylic acid Property
- Melting point:
- 100.1-101.9°C
- Boiling point:
- 321.0±35.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.21±0.20(Predicted)
- form
- Crystalline Powder
- color
- White
- BRN
- 8832105
- InChI
- InChI=1S/C9H15NO4/c1-9(2,3)14-8(13)10-4-6(5-10)7(11)12/h6H,4-5H2,1-3H3,(H,11,12)
- InChIKey
- NCADHSLPNSTDMJ-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(C(O)=O)C1
- CAS DataBase Reference
- 142253-55-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-37-26
- WGK Germany
- 3
- TSCA
- No
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 09928
- Product name
- 1-Boc-azetidine-3-carboxylic acid
- Purity
- ≥98.0% (TLC)
- Packaging
- 500mg
- Price
- $407
- Updated
- 2023/06/20
- Product number
- B3540
- Product name
- 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- B3540
- Product name
- 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $265
- Updated
- 2025/07/31
- Product number
- B630008
- Product name
- 1-Boc-azetidine-3-carboxylic acid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 236079
- Product name
- Boc-azetidine-3-carboxylic acid 98+%
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
1-N-Boc-3-Azetidinecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
light yellow powder
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
36476-78-5
142253-55-2
General procedure for the synthesis of 1-Boc-azetidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-acridinecarboxylic acid: Example 4 Synthesis of 6-(3-{[(benzylsulfonyl)amino]carbonyl}azetidin-1-yl)-5-cyano-2-(difluoromethyl)nicotinate (a) Preparation of ethyl 1-(tert-butoxycarbonyl)azetidine-3-carboxylate Di-tert-butyl dicarbonate (25.535 g, 117 mmol) dissolved in methanol (70 mL) was added dropwise to a stirred solution of azetidine-3-carboxylic acid (10.11 g, 100 mmol) and triethylamine (27.8 mL, 200 mmol) in methanol (105 mL) over a period of 20 min. The reaction was carried out at room temperature (mild exotherm was observed) with continuous stirring for 18 hours. Upon completion of the reaction, the mixture was evaporated to dryness, tetrahydrofuran (120 mL) was added and evaporated again to afford the crude 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid, which could be used in the next step without further purification. Yield: 25.89 g (128%). 1H NMR (400 MHz, CDCl3) δ 1.43 (9H, s), 3.21-3.34 (1H, m), 4.00-4.13 (4H, m).
References
[1] Patent: WO2008/4946, 2008, A1. Location in patent: Page/Page column 90-91
[2] Patent: US2008/171732, 2008, A1. Location in patent: Page/Page column 36
[3] Patent: WO2008/85119, 2008, A1. Location in patent: Page/Page column 175-176
[4] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 98
[5] Patent: WO2008/95912, 2008, A2. Location in patent: Page/Page column 77
1-N-Boc-3-Azetidinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-Boc-3-Azetidinecarboxylic acid Suppliers
- Tel
- --
- Fax
- --
- sales21@chemicalland21.com
- Country
- South Korea
- ProdList
- 6303
- Advantage
- 74
View Lastest Price from 1-N-Boc-3-Azetidinecarboxylic acid manufacturers
- Product
- 1-Boc-azetidine-3-carboxylic acid 142253-55-2
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-24
- Product
- 1-N-Boc-3-Azetidinecarboxylic acid 142253-55-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 1-N-Boc-3-Azetidinecarboxylic acid 142253-55-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27