4-Chloro-5-Bromopyrimidine
- Product Name
- 4-Chloro-5-Bromopyrimidine
- CAS No.
- 56181-39-6
- Chemical Name
- 4-Chloro-5-Bromopyrimidine
- Synonyms
- 4-Chloro-5-Bromopyrimidine;4-Chloro-5-bromopyrimidin...;Pyrimidine, 5-bromo-4-chloro-;4-Chloro-5-Bromopyrimidine ISO 9001：2015 REACH
- CBNumber
- CB71270902
- Molecular Formula
- C4H2BrClN2
- Formula Weight
- 193.43
- MOL File
- 56181-39-6.mol
4-Chloro-5-Bromopyrimidine Property
- Boiling point:
- 250.7±20.0 °C(Predicted)
- Density
- 1.859±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.41±0.16(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B684708
- Product name
- 5-Bromo-4-chloropyrimidine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B684708
- Product name
- 5-Bromo-4-chloropyrimidine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3H32-D-16
- Product name
- 5-Bromo-4-chloropyrimidine
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- X3070
- Product name
- 4-Chloro-5-Bromopyrimidine
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 068691
- Product name
- 4-Chloro-5-bromopyrimidine
- Purity
- >95%
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
4-Chloro-5-Bromopyrimidine Chemical Properties,Usage,Production
Chemical Properties
Pale yellow crystal
Synthesis
19808-30-1
56181-39-6
The general procedure for the synthesis of 4-chloro-5-bromopyrimidine using 5-bromopyrimidin-4-one as starting material was as follows: to a mixture of 5-bromopyrimidin-4-ol (40 g, 0.22 mol) dissolved in POCl3 (300 mL) was added drop-wise DIPEA (29 g, 0.22 mol) at room temperature. Subsequently, the reaction mixture was heated to reflux and maintained for 3 hours. The progress of the reaction was monitored by TLC (unfolding agent ratio of petroleum ether/EtOAc 1:1) to confirm the completion of the reaction. Upon completion of the reaction, excess POCl3 was removed by distillation under reduced pressure. the residue was slowly poured into ice water (300 mL) under stirring. The aqueous phase was extracted with EtOAc (2 × 300 mL), the organic layers were combined and washed sequentially with water (300 mL) and brine (300 mL), dried over Na2SO4 and finally concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent ratio of petroleum ether/EtOAc, gradient from 20:1 to 10:1) to afford the target product 5-bromo-4-chloropyrimidine (25 g, 60% yield) as a yellow oil.
References
[1] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 88
[2] Patent: WO2012/135631, 2012, A1. Location in patent: Page/Page column 21-22
[3] Patent: WO2010/88518, 2010, A2. Location in patent: Page/Page column 86-87
[4] Organic Process Research and Development, 2000, vol. 4, # 4, p. 275 - 285
4-Chloro-5-Bromopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-5-Bromopyrimidine manufacturers
- Product
- 4-Chloro-5-Bromopyrimidine 56181-39-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
- Product
- 4-Chloro-5-Bromopyrimidine 56181-39-6
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-03-13