CHONDROITINASE ABC
- Product Name
- CHONDROITINASE ABC
- CAS No.
- 9024-13-9
- Chemical Name
- CHONDROITINASE ABC
- Synonyms
- EC 4.2.2.4;units/mg solid;CHONDROITINASE ABC;chondroitinase ABC I;CHONDROITIN ABC LYASE;Lyase, chondroitin ABC;chondroitinase-abc bsa free;Chondroitinase ABC, Recomb.;lyophilized powder, 0.3-3 chondroitin-sulfate-ABC endolyase
- CBNumber
- CB7143258
- Molecular Formula
- NULL
- Formula Weight
- 0
- MOL File
- Mol file
CHONDROITINASE ABC Property
- storage temp.
- -20°C
- solubility
- 0.01% bovine serum albumin aqueous (BSA) solution: soluble
- form
- lyophilized powder
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- C3667
- Product name
- Chondroitinase ABC from Proteus vulgaris
- Purity
- BSA free, lyophilized powder, specific activity 50-250 units/mg protein
- Packaging
- 5units
- Price
- $283
- Updated
- 2024/03/01
- Product number
- SAE0150
- Product name
- Chondroitinase ABC from Proteus vulgaris
- Purity
- recombinant, low endotoxin, aqueous solution, ≥100 U/ml, 50-250 units/mg protein, BSA free
- Packaging
- 0.1ML
- Price
- $477
- Updated
- 2024/03/01
- Product number
- C2905
- Product name
- Chondroitinase ABC from Proteus vulgaris
- Purity
- lyophilized powder, 0.3-3?units/mg solid
- Packaging
- 2units
- Price
- $112
- Updated
- 2024/03/01
- Product number
- C3667
- Product name
- Chondroitinase ABC from Proteus vulgaris
- Purity
- BSA free, lyophilized powder, specific activity 50-250 units/mg protein
- Packaging
- 10units
- Price
- $481
- Updated
- 2024/03/01
- Product number
- C2905
- Product name
- Chondroitinase ABC from Proteus vulgaris
- Purity
- lyophilized powder, 0.3-3?units/mg solid
- Packaging
- 5units
- Price
- $226
- Updated
- 2024/03/01
CHONDROITINASE ABC Chemical Properties,Usage,Production
Uses
Chondroitinase ABC from Sigma has been used to digest O-linked chondroitin sulfate-like glycosaminoglycan (CSGAG). The enzyme has also been used to digest glycosaminoglycan chains in proteoglycans during the construction and expression of a recombinant versican gene in mammalian systems. Furthermore, it has been used to digest chondroitin sulfate in the proteoglycan complexes. The enzyme has also been used in the removal of glycan chains from aggrecan, which eliminates the axon growth-inhibitory effect of aggrecan.
Uses
The enzyme has been used to study the consequences of inducing acute, long-lasting changes in chondroitin sulfate proteoglycans using adult rat brain cells. Glycosaminoglycans have been digested with chondroitinase ABC for chondroitin/dermatan sulfate quantitation in keratocyte cell cultures obtained from fresh bovine corneal stromae.
Biochem/physiol Actions
Chondroitinase ABC catalyzes the eliminative degradation of polysaccharides containing (1-4)-β-D-hexosaminyl and (1-3)-β-D-glucuronosyl (or (1-3)-α-L-iduronosyl) linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups. It acts on chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate. However, it acts slowly on hyaluronate. The molecular weight is approximately 120 kDa with 2 non-identical subunits of molecular masses 86 kDa and 32 kDa. The pH optimum is 8.0 with chondroitin sulfate and 6.8 with hyaluronic acid. The optimal temperature is 37 °C. 1 mM Zn2+ acts as an inhibitor, while 0.05 M acetate is an activator of the enzyme.
CHONDROITINASE ABC Preparation Products And Raw materials
Raw materials
Preparation Products
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