N-BOC-(METHYLAMINO)ACETALDEHYDE

Product Name: N-BOC-(METHYLAMINO)ACETALDEHYDE
CAS No.: 123387-72-4
Chemical Name: N-BOC-(METHYLAMINO)ACETALDEHYDE
Synonyms: N-Boc-(methyL;Macitentan Impurity 51;N-BOC-(METHYLAMINO)ACETALDEHYDE;N-Boc-2-(methylamino)acetaldehyde;ert-butylN-methyl-N-(2-oxoethyl)carbamate;tert-Butyl N-methyl-N-(2-oxoethyl)carbamate;O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate;N-tert-Butoxycarbonyl-(methylamino)acetaldehyde;N-methyl-N-(2-oxoethyl)-, 1,1-dimethylethyl ester;N-(tert-butoxycarbonyl)-N-MethylaMinoacetaldehyde
CBNumber: CB71480019
Molecular Formula: C8H15NO3
Formula Weight: 173.21
MOL File: 123387-72-4.mol

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N-BOC-(METHYLAMINO)ACETALDEHYDE Property

Boiling point:: 218.2±19.0 °C(Predicted)
Density: 1.026g/ml
refractive index: 1.44
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: clear liquid
pka: -1.63±0.70(Predicted)
color: Colorless to Light yellow
Water Solubility: Slightly miscible with water.
Sensitive: Air Sensitive
InChI: InChI=1S/C8H15NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h6H,5H2,1-4H3
InChIKey: MSWTVSDFEYSRMQ-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)N(C)CC=O

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5825
Product name: N-tert-Butoxycarbonyl-(methylamino)acetaldehyde
Purity: >96.0%(GC)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: B5825
Product name: N-tert-Butoxycarbonyl-(methylamino)acetaldehyde
Purity: >96.0%(GC)
Packaging: 5g
Price: $126
Updated: 2025/07/31

TRC

Product number: B656860
Product name: N-Boc-(Methylamino)acetaldehyde
Packaging: 2.5g
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-B0863
Product name: tert-Butylmethyl(2-oxoethyl)carbamate
Purity: 98.44%
Packaging: 5g
Price: $71
Updated: 2021/12/16

ChemScene

Product number: CS-B0863
Product name: tert-Butylmethyl(2-oxoethyl)carbamate
Purity: 98.44%
Packaging: 10g
Price: $124
Updated: 2021/12/16

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N-BOC-(METHYLAMINO)ACETALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

N-Boc-(methylamino)acetaldehyde is involved in the preparation of benzo[d]imidazole inhibitor of co-activator associated arginine methyltransferase.

Synthesis

57561-39-4

123387-72-4

General procedure for the synthesis of N-Boc-(methylamino)acetaldehyde from N-BOC-N-methylaminoethanol: (a) Dess-Martin periodontane (22 g, 52 mmol) was added batchwise to a solution of 2-(N-Boc-methylamino)ethanol (8.8 g, 50 mmol) dissolved in dichloromethane at 0 °C. The reaction mixture was naturally warmed to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution and sodium thiosulfate solution were added and stirring was continued for 0.5 hours. Subsequently, the organic phase was separated, washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate, and concentrated to give 9 g (quantitative yield) of the title compound N-Boc-(methylamino)acetaldehyde. The product was analyzed by GC-MS and showed m/z 174 (M + 1).

References

[1] Patent: WO2007/120098, 2007, A1. Location in patent: Page/Page column 88
[2] Patent: WO2013/68552, 2013, A1. Location in patent: Page/Page column 53
[3] ChemMedChem, 2015, vol. 10, # 3, p. 470 - 489
[4] Patent: WO2011/133039, 2011, A2. Location in patent: Page/Page column 202
[5] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 21, p. 3219 - 3225

N-BOC-(METHYLAMINO)ACETALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-(METHYLAMINO)ACETALDEHYDE Suppliers

Americas 1 Canada 1 China 105 Europe 1 Germany 1 India 4 Japan 1 United States 13 Global 127

Sci General Material & Chemical Ltd

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View Lastest Price from N-BOC-(METHYLAMINO)ACETALDEHYDE manufacturers

Career Henan Chemical Co

Product: tert-butyl N-methyl-N-(2-oxoethyl)carbamate 123387-72-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

123387-72-4, N-BOC-(METHYLAMINO)ACETALDEHYDERelated Search:

Boc-Hyp-OH BOC-L-Proline BOC-HYP(BZL)-OH BOC-3,4-DEHYDRO-PRO-OH BOC-PRO-OSU Boc-N-Me-Val-OH Boc-N-methyl-L-phenylalanine Boc-N-methyl-L-leucine N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine BOC-N-Methyl-L-alanine BOC-SAR-OH Boc-N-Methyl-L-phenylglycine BOC-N-ME-ALLO-ILE-OH BOC-PRO-PRO-OH BOC-N-ME-P-NITRO-PHE-OH DCHA BOC-N-ME-GLU(OBZL)-OH BOC-N-ME-TYR(2,6-DICHLORO-BZL)-OH BOC-PRO-LEU-VAL-OME

tert-Butyl N-methyl-N-(2-oxoethyl)carbamate

N-(tert-butoxycarbonyl)-N-MethylaMinoacetaldehyde

N-Boc-2-(methylamino)acetaldehyde

CARBAMIC ACID,N-METHYL-N-(2-OXOETHYL)-, 1,1-DIMETHYLETHYL ESTER

N-BOC-(METHYLAMINO)ACETALDEHYDE

N-methyl-N-(2-oxoethyl)-, 1,1-dimethylethyl ester

O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate

N-tert-Butoxycarbonyl-(methylamino)acetaldehyde

N-Boc-(methyL

ert-butylN-methyl-N-(2-oxoethyl)carbamate

1,1-Dimethylethyl N-methyl-N-(2-oxoethyl)carbamate

Macitentan Impurity 51

123387-72-4

Indolines ,Indoles