Piperonylic acid

Product Name: Piperonylic acid
CAS No.: 94-53-1
Chemical Name: Piperonylic acid
Synonyms: Benzo[d][1,3]dioxole-5-carboxylic acid;Heliotropic acid;1,3-BENZODIOXOLE-5-CARBOXYLIC ACID;PIPEROYLICACID;3,4-(METHYLENEDIOXY)BENZOIC ACID;AKOS 213-90;Pepper acid;heliotropicacid;PIPERONYLIC ACID;PiperonylicAcid>
CBNumber: CB7162666
Molecular Formula: C8H6O4
Formula Weight: 166.13
MOL File: 94-53-1.mol

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Piperonylic acid Property

Melting point:: 229-231 °C (lit.)
Boiling point:: 254.32°C (rough estimate)
Density: 1.3579 (rough estimate)
refractive index: 1.5090 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 4.35±0.20(Predicted)
form: Powder
color: Off-white to beige
Water Solubility: slightly soluble
Merck: 14,7477
BRN: 150206
LogP: 0.810 (est)
CAS DataBase Reference: 94-53-1(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Benzodioxole-5-carboxylic acid(94-53-1)
EPA Substance Registry System: 1,3-Benzodioxole-5-carboxylic acid (94-53-1)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38
Safety Statements: 26-36/37/39-37/39
WGK Germany: 3
RTECS: DF4912765
Hazard Note: Irritant
TSCA: Yes
HS Code: 29329970

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P49805
Product name: Piperonylic acid
Purity: 99%
Packaging: 5g
Price: $59
Updated: 2024/03/01

Sigma-Aldrich

Product number: P49805
Product name: Piperonylic acid
Purity: 99%
Packaging: 25g
Price: $98
Updated: 2024/03/01

TCI Chemical

Product number: P0459
Product name: Piperonylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $50
Updated: 2024/03/01

Alfa Aesar

Product number: A14105
Product name: Piperonylic acid, 98+%
Packaging: 25g
Price: $59.65
Updated: 2024/03/01

Alfa Aesar

Product number: A14105
Product name: Piperonylic acid, 98+%
Packaging: 100g
Price: $192
Updated: 2024/03/01

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Piperonylic acid Chemical Properties,Usage,Production

Chemical Properties

It is a white to light yellow crystalline powder, slightly soluble in water, chloroform, cold ethanol, and ether.

Uses

Piperonylic Acid is a compound closely mimicking the structure of transcinnamic acid involved in the phenylpropanoid pathway in plant physiology.

Definition

ChEBI: Piperonylic acid is a member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5. It is a natural product isolated from several plant species. It is a selective mechanism-based inactivator of the trans-cinnamate 4-hydroxylase enzyme and exhibits antifungal and skin wound healing properties. It has a role as a plant metabolite, an EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor, a vulnerary and an antifungal agent. It is a member of benzodioxoles, a monocarboxylic acid and an aromatic carboxylic acid. It is a conjugate acid of a piperonylate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 40, p. 3803, 1975 DOI: 10.1021/jo00913a051

Purification Methods

Crystallise the acid from EtOH or water. [Beilstein 19/7 V 300.]

References

[1] OTTO RICHARD GOTTLIEB MAURO T M. Isolation of Piperonylic Acid from Ocotea pretiosa[J]. Nature, 1958, 182 4637: 742-743. DOI:10.1038/182742b0.
[2] SEUNG HYUN HAN. Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway.[J]. International Journal of Molecular Sciences, 2024, 25 19. DOI:10.3390/ijms251910774.
[3] SCHALK. Piperonylic acid, a selective, mechanism-based inactivator of the trans-cinnamate 4-hydroxylase: A new tool to control the flux of metabolites in the phenylpropanoid pathway[J]. Plant Physiology, 1998, 118 1: 209-218. DOI:10.1104/pp.118.1.209.

Piperonylic acid Preparation Products And Raw materials

Raw materials

Potassium hydroxide Piperonyl aldehyde Potassium permanganate

Preparation Products

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Piperonylic acid Suppliers

Americas 1 Belgium 2 China 267 Europe 3 France 1 Germany 6 India 8 Italy 2 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 12 United States 40 Global 351

Hangzhou Lenny Technology Co. , Ltd.

Tel: 571-88086013
Fax: 0571- 88088387
Email: sunnie@rdpharm.com
Country: China
ProdList: 89
Advantage: 60

MINKESH (SHANGHAI) CO., LTD.

Tel: +86-021-20980300 +86-13167252998
Fax: 021-20983811
Email: sales@minkesh.com
Country: China
ProdList: 76
Advantage: 55

Suzhou lipin Chemical Co., Ltd

Tel: 0512-0512-67509664 19888480046
Country: China
ProdList: 121
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

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View Lastest Price from Piperonylic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Piperonylic acid 94-53-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-25

Jinan Finer Chemical Co., Ltd

Product: Piperonylic acid 94-53-1
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 200mt/year
Release date: 2021-07-12

Hebei Weibang Biotechnology Co., Ltd

Product: Piperonylic acid 94-53-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-06

94-53-1, Piperonylic acidRelated Search:

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1,3-BENZODIOXOLE-5-CARBOXYLIC ACID

3,4-METHYLENDIOXYBENZOIC ACID

3,4-(METHYLENEDIOXY)BENZOIC ACID

RARECHEM AL BO 0210

3,4-(methylenedioxy)benzoic acid, piperonylic acid

Piperonylic acid, 98+%

PIPEROYLICACID

3,4-Methylendioxybenzoic acid 98%

AKOS 213-90

β(3,4-methylenedioxy-styryl)acrylic acid

5-carboxy-2H-1,3-benzodioxol-5-iuM

1,3-Benzodioxole-5-carboxylic acid 98%

3,4-(Methylendioxy)benzoic acid, Piperonylic acid

1,3-Benzodioxole-5-carboxylic acid, 3,4-(Methylenedioxy)benzoic acid

Piperonylic acid ,99%

3,4-Methylenebisoxybenzoic acid

2-phenyl-2H-1,3-dioxole-4-carboxylic acid

Piperonylic acid,1,3-Benzodioxole-5-carboxylic acid, 3,4-(Methylenedioxy)benzoic acid

Benzo[d][1,3]dioxole-5-carboxylic acid

TIMTEC-BB SBB003897

5-benzodioxolecarboxylicacid

Benzoic acid, 3,4-(methylenedioxy)-

Heliotropic acid

heliotropicacid

Protocatechuic acid methylene ether

3,4-dioxymethylenebenzoicacid

PIPERONYLIC ACID

PROTOCATECHUIC ACID METHYLENETHER

5-Carboxy-1,3-benzodioxole, 3,4-(Methylendioxy)benzoic acid, Piperonylic acid

Piperonylic acid 99%

PiperonylicAcid&gt

Tadalafil Impurity 90

Pepper acid

94-53-1

94-53-11

OCH2OC6H3COOH

CH2O2C6H3COOH

C8H6O4

CH2O2C6H3CHCHCHCHCOOH

Carboxylic Acids

Carbonyl Compounds

C8

Building Blocks

Organic Building Blocks

Building Blocks

C8

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Benzodiozoles, Benzodioxines & Benzodioxepines

Carboxylic Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzodiozoles, Benzodioxines & Benzodioxepines

Carboxylic Acids

Quinoxalines ,Quinazolines ,Quinaldines