2-Bromo-4'-fluoroacetophenone

Product Name: 2-Bromo-4'-fluoroacetophenone
CAS No.: 403-29-2
Chemical Name: 2-Bromo-4'-fluoroacetophenone
Synonyms: 2-bromo-1-(4-fluorophenyl)ethan-1-one;4-FLUOROPHENACYL BROMIDE;2-BROMO-1-(4-FLUOROPHENYL)ETHANONE;2-Bromo-4'-fL;Vonoprazan-032;AKOS BBS-00003857;BUTTPARK 41\03-58;TIMTEC-BB SBB006561;TAK438 Impurity 101;TAK438 Impurity 102
CBNumber: CB7169175
Molecular Formula: C8H6BrFO
Formula Weight: 217.04
MOL File: 403-29-2.mol

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2-Bromo-4'-fluoroacetophenone Property

Melting point:: 47-49 °C(lit.)
Boiling point:: 150 °C12 mm Hg(lit.)
Density: 1.5728 (rough estimate)
refractive index: 1.5450 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in methanol.
form: Powder
color: White to brownish-yellow to light grey
Sensitive: Lachrymatory
BRN: 637863
CAS DataBase Reference: 403-29-2(CAS DataBase Reference)
NIST Chemistry Reference: Acetophenone, 2-bromo-4'-fluoro-(403-29-2)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34
Safety Statements: 26-36/37/39-45-27
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive/Lachrymatory/Keep Cold
HazardClass: 8
PackingGroup: III
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 389390
Product name: 2-Bromo-4′-fluoroacetophenone
Purity: 97%
Packaging: 5g
Price: $31.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 389390
Product name: 2-Bromo-4′-fluoroacetophenone
Purity: 97%
Packaging: 25g
Price: $96.6
Updated: 2025/07/31

TCI Chemical

Product number: B2382
Product name: 2-Bromo-4'-fluoroacetophenone
Purity: >97.0%(GC)
Packaging: 5g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: B2382
Product name: 2-Bromo-4'-fluoroacetophenone
Purity: >97.0%(GC)
Packaging: 25g
Price: $140
Updated: 2025/07/31

TRC

Product number: B684615
Product name: 2-Bromo-4’-fluoroacetophenone
Packaging: 25g
Price: $210
Updated: 2021/12/16

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2-Bromo-4'-fluoroacetophenone Chemical Properties,Usage,Production

Chemical Properties

beige to light grey-green cryst. powder or flakes

Uses

2-Bromo-4'-fluoroacetophenone is used as an organic chemical synthesis intermediate.

Uses

2-Bromo-4’fluoroacetophenone is a intermediate in the synthetic preparation of competitive inhibitors of aromatase.

Synthesis

403-42-9

403-29-2

General procedure for the synthesis of 2-bromo-4'-fluoroacetophenone using 4-fluoroacetophenone as starting material: general method: oxone (1.352 g, 2.2 mmol) was added to a well-stirred methanol (10 ml) solution of 4-fluoroacetophenone (2 mmol) and NH4Br (0.215 g, 2.2 mmol), and the reaction mixture was stirred at room temperature (or refluxed at temperature reaction). The reaction progress was monitored by TLC. Upon completion of the reaction, the reaction mixture was quenched with aqueous sodium thiosulfate, followed by extraction with ethyl acetate (3 x 25 ml). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to remove the solvent to give the crude product. The crude product was further purified by silica gel column chromatography (200-300 mesh) to give pure 2-bromo-4'-fluoroacetophenone. All products were structurally confirmed by 1H NMR and mass spectrometry data.

References

[1] Farmaco, 1993, vol. 48, # 6, p. 857 - 869
[2] Synthesis, 2008, # 2, p. 253 - 266
[3] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
[4] Tetrahedron, 1992, vol. 48, # 1, p. 67 - 78
[5] Bulletin of the Chemical Society of Japan, 1999, vol. 72, # 6, p. 1327 - 1334

2-Bromo-4'-fluoroacetophenone Preparation Products And Raw materials

Raw materials

Chloroform 4-Fluoroacetophenone Sodium bicarbonate Bromine Acetic acid

Preparation Products

5-AMINO-3-(4-FLUOROPHENYL)ISOXAZOLE

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2-Bromo-4'-fluoroacetophenone Suppliers

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View Lastest Price from 2-Bromo-4'-fluoroacetophenone manufacturers

Henan Fengda Chemical Co., Ltd

Product: p-Fluorophenacyl bromide 403-29-2
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Honest Joy Holdings Limited

Product: 2-Bromo-4'-fluoroacetophenone 403-29-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2022-02-20

403-29-2, 2-Bromo-4'-fluoroacetophenoneRelated Search:

Ethidium bromide Ethyl bromodifluoroacetate Rocuronium bromide 4'-Hydroxyacetophenone 4'-Methylacetophenone Benzyl bromide Acetophenone Trifluoroacetophenone PIPERACETAZINE (250 MG) Sodium bromate 4'-Bromoacetophenone 2-Bromoacetophenone 3'-Fluoroacetophenone DIPHENYLCYCLOPROPENONE 4-Fluoroacetophenone 4'-(Trifluoromethyl)acetophenone 3-Nitroacetophenone 4'-Fluoropropiophenone

AKOS BBS-00003857

4-FLUOROPHENACYL BROMIDE

2-bromo-1-(4-fluorophenyl)ethan-1-one

alpha-Bromo-4-Fluoro Acetophenone 2'-Bromo-4-Fluoro Acetophenone

z-Bromo-4-fluoroacetophenone

4-Fluorophenacyl bromide (alpha-Bromo-4-fluoroacetophenone), 97%

Ethanone, 2-bromo-1-(4-fluorophenyl)- (9CI)

4-Fluorophenacylbromide,97%

4-Fluorophenacyl bromide 97%

4-fluorophenacyl bromide ,2-bromo-1-(4-fluorophenyl)ethanone

ω-Bromo-4-fluoroacetophenone, 4-Fluorophenacyl bromide

1-(4-Fluorophenyl)-2-bromoethanone

2-Bromo-p-fluoroacetophenone

Bromomethyl 4-fluorophenyl ketoxime

1-(Bromoacetyl)-4-fluorobenzene

4'-Fluoro-α-bromoacetophenone

Bromomethyl 4-fluorophenyl ketone

4-Fluorophenacyl bromide (alpha-Bromo-4-fl

JR-8907, 2-Bromo-4'-fluoroacetophenone, 97%

2-Bromo-4'-fluoroacetophenone, >97.0%(GC)

2-Bromo-4'-fluoroacetophenone,99%

2-Bromo-4'-fluoroacetophenone, 2-Bromo-1-(4-fluorophenyl)ethan-1-one

2-Bromo-4'-fluoroace

P-FLUOROPHENACYL BROMIDE

Bromo-4-fluoroacetophenone

Ethanone, 2-bromo-1-(4-fluorophenyl)-

omega-Bromo-4-fluoroacetophenone

BUTTPARK 41\03-58

2-BROMO-1-(4-FLUOROPHENYL)ETHANONE

2'-BROMO-4-FLUOROACETOPHENONE

ALPHA-BROMO-4-FLUOROACETOPHENONE

TIMTEC-BB SBB006561

2-Bromo-4'-fL

2-Bromo-4'-fluoroacetophenone &gt

TAK438 Impurity 101

Vonoprazan-032

Vonoprazan Impurity 101

Vonoprazan Impurity 102

403-29-2 2-Bromo-4'-fluoroacetophenone

α-bromo-4-fluoroacetophenone

2-bromo-4'-fluoroacetophenone

1-((4-chloropyridin-3-yl)sulfonyl)-2-(2-fluorophenyl)-4-((methylamino)methyl)-1H-pyrrole 1-oxide

2-Bromo-4′-fluoroacetophenone, CAS 403-29-2

TAK438 Impurity 102

403-29-2

FC6H4COCH2Br

Organic Building Blocks

Ketones

Building Blocks

Carbonyl Compounds

C7 to C8

Acetophenone series

Benzenes

ACETYLHALIDE

Benzene series

Aryl Fluorinated Building Blocks

B

Bioactive Small Molecules