3-Bromothiophene
- Product Name
- 3-Bromothiophene
- CAS No.
- 872-31-1
- Chemical Name
- 3-Bromothiophene
- Synonyms
- S0501;DK938;3-Bromthiophen;β-bromothiophene;3-bromo-thiophen;3-BroMothiofuran;3-Bromothiophene;b-Bromothiophene;3-THIENYL BROMIDE;BROMOTHIOPHENE(3-)
- CBNumber
- CB7196229
- Molecular Formula
- C4H3BrS
- Formula Weight
- 163.04
- MOL File
- 872-31-1.mol
3-Bromothiophene Property
- Melting point:
- <-10°C
- Boiling point:
- 150 °C (lit.)
- Density
- 1.74 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.591(lit.)
- Flash point:
- 140 °F
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- Specific Gravity
- 1.740
- color
- Clear colorless to slightly yellow
- Water Solubility
- IMMISCIBLE
- Sensitive
- Light Sensitive/Stench
- BRN
- 105338
- CAS DataBase Reference
- 872-31-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Thiophene, 3-bromo-(872-31-1)
- EPA Substance Registry System
- 3-Bromothiophene (872-31-1)
Safety
- Hazard Codes
- T,Xi,N,Xn
- Risk Statements
- 10-25-41-51/53-36/37/38-23/24/25-20/21/22-43-36/37
- Safety Statements
- 26-36/37/39-45-61-38-28A-16-24/25-23-36-36/37-24/35
- RIDADR
- UN 2929 6.1/PG 2
- WGK Germany
- 3
- F
- 8
- Hazard Note
- Irritant
- TSCA
- T
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H301Toxic if swalloed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 106224
- Product name
- 3-Bromothiophene
- Purity
- 97%
- Packaging
- 5g
- Price
- $60.3
- Updated
- 2025/07/31
- Product number
- 106224
- Product name
- 3-Bromothiophene
- Purity
- 97%
- Packaging
- 25g
- Price
- $97.6
- Updated
- 2025/07/31
- Product number
- B1067
- Product name
- 3-Bromothiophene
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- B1067
- Product name
- 3-Bromothiophene
- Purity
- >97.0%(GC)
- Packaging
- 250g
- Price
- $446
- Updated
- 2025/07/31
- Product number
- 106224
- Product name
- 3-Bromothiophene
- Purity
- 97%
- Packaging
- 100g
- Price
- $171
- Updated
- 2025/07/31
3-Bromothiophene Chemical Properties,Usage,Production
Chemical Properties
clear colourless to slightly yellow liquid. It is not soluble in water, but can dissolve in common organic solvents such as chloroform, benzene, ether, and tetrahydrofuran.
Uses
3-Bromothiophene is used in the preparation of derivatives such as thienylenic alpha, μ-diformyl-alpha-oligothiophenes and 3-lithiothiophene. It is also used in the synthesis of 3-lithiothiophene by reacting with n-butyllithium.
Uses
3-Bromothiophene can be used as a reactant to synthesize:
3,3-Bithiophene via borylation followed by Suzuki coupling.
3-Alkylthiophenes by NiDPPP++ catalyzed cross-coupling with Grignard reagents.
3-Lithiothiophene by treating with n-butyllithium in hexane.
Derivatives of thienylenic α, ω?diformyl?α?oligothiophenes.
N-(2-(3-bromothiophen-2-yl)phenyl)methanesulfonamides by coupling at the 2-position with N-arylmethanesulfonamides, mediated by iodobenzene diacetate (178721).
Preparation
Preparation of 3-bromothiophene using 2,5-dibromothiophene
2,5-Dibromothiophene (121g, 0.5 moles), tris (3,6-dioxaheptyl) amine (1.0g, 0.003 mole), thiophene (500 cm3) and sodium amide (58.5g, 1.5 mole) were successively charged to a flask which had previously been purged with nitrogen. The reaction mixture was stirred and heated under nitrogen at 50-60°C for 6 hours. The product, after work up as described in Example 3, was found to contain 138.5g 3-bromothiophene and 2.6g 2-bromothiophene. The yield of 3-bromothiophene was 85% and the monobromothiophenes were in the ratio of 2 parts 2-bromothiophene to 98 parts 3-bromothiophene.
Reactions
3-Bromothiophene is an electron-rich aromatic hydrocarbon bromide. The bromine atom in it has good electrophilicity. It can perform a Suzuki coupling reaction under the catalysis of metal palladium, and react with different aryl or alkenyl borates. The corresponding substitution products are generated. This reaction is one of the very important methods in organic synthesis, which can build C-C bonds and form complex organic molecular structures.
Synthesis Reference(s)
Journal of the American Chemical Society, 74, p. 2965, 1952 DOI: 10.1021/ja01132a004
Synthetic Communications, 11, p. 25, 1981 DOI: 10.1080/00397918108064278
3-Bromothiophene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromothiophene manufacturers
- Product
- 3-Bromothiophene 872-31-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-07
- Product
- 3-Bromothiophene 872-31-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
- Product
- 3-Bromothiophene 872-31-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27