ChemicalBook > CAS DataBase List > 2-Nitro-4-trifluoromethylbenzoic acid

2-Nitro-4-trifluoromethylbenzoic acid

Product Name: 2-Nitro-4-trifluoromethylbenzoic acid
CAS No.: 320-94-5
Chemical Name: 2-Nitro-4-trifluoromethylbenzoic acid
Synonyms: 2NTF-BOA;2-Nitro-4-(trifL;BUTTPARK 24\10-94;RARECHEM AL BO 0289;2-Nitro-4-trifluorom;Nitrotrifluoromethylbenzoicacid;Nitro-4-(trifluoroMethyl)benzoi;2-nitro-α,α,α-trifluor-p-toluic acid;α,α,α-Trifluoro-2-nitro-p-toluic Acid;2-NITRO-4-(TRIFLUOROMETHYL)BENZOIC ACID
CBNumber: CB7215186
Molecular Formula: C8H4F3NO4
Formula Weight: 235.12
MOL File: 320-94-5.mol

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2-Nitro-4-trifluoromethylbenzoic acid Property

Melting point:: 134-138 °C(lit.)
Boiling point:: 306.6±42.0 °C(Predicted)
Density: 1.596±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO, Methanol
pka: 1.70±0.25(Predicted)
form: Crystalline Powder
color: Pale yellow
BRN: 1985588
CAS DataBase Reference: 320-94-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 328901
Product name: 2-Nitro-4-(trifluoromethyl)benzoic acid
Purity: 98%
Packaging: 1g
Price: $24.5
Updated: 2025/07/31

TCI Chemical

Product number: N0720
Product name: 2-Nitro-4-(trifluoromethyl)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: N0720
Product name: 2-Nitro-4-(trifluoromethyl)benzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $157
Updated: 2025/07/31

TRC

Product number: N596800
Product name: 2-Nitro-4-(trifluoromethyl)benzoic Acid
Packaging: 10g
Price: $145
Updated: 2021/12/16

TRC

Product number: N596800
Product name: 2-Nitro-4-(trifluoromethyl)benzoic Acid
Packaging: 50g
Price: $495
Updated: 2021/12/16

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2-Nitro-4-trifluoromethylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

2-Nitro-4-(trifluoromethyl)benzoic Acid (cas# 320-94-5) is a compound useful in organic synthesis.

Synthesis

455-24-3

320-94-5

Example 2 a) Synthesis of 2-nitro-4-trifluoromethylbenzoic acid: 11.97 g (63 mmol) of 4-trifluoromethylbenzoic acid was slowly added in batches to 48 mL of concentrated nitric acid (100%) at room temperature. Subsequently, the reaction mixture was heated to reflux for 1 h. After completion of the reaction, it was cooled to room temperature and slowly poured into about 600 g of ice. After stirring the mixture for 1 hour, the precipitate was collected by filtration and washed with 1 L of water. The filtrate was extracted with 300 mL of dichloromethane (CH2Cl2), the organic phase was combined with the precipitate and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by distillation under reduced pressure and the residue was recrystallized by dissolving in 1 L of diisopropyl ether (DIP) and adding 2 L of heptane (HEP) at 68 °C, followed by slow cooling of the solution to room temperature. The crystalline product was washed with 1 L of heptane and dried under reduced pressure to give 7.1 g (48% yield) of 2-nitro-4-trifluoromethylbenzoic acid with a melting point of 136 °C - 138 °C.

References

[1] Patent: US2005/124681, 2005, A1. Location in patent: Page/Page column 16

2-Nitro-4-trifluoromethylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Nitro-4-trifluoromethylbenzoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Nitro-4-trifluoromethylbenzoic acid 320-94-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-18

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Nitro-4-(trifluoromethyl)benzoic acid 320-94-5
Price: US $1500.00/KG
Min. Order: 1KG
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-04-14

Wuhan Boye Science And Technology Development Co., Ltd.

Product: 2-Nitro-4-trifluoromethylbenzoic acid 320-94-5
Price: US $0.00/KG
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 100KG
Release date: 2021-04-14

320-94-5, 2-Nitro-4-trifluoromethylbenzoic acidRelated Search:

2-(Trifluoromethyl)benzoic acid 3-(Trifluoromethyl)benzoic acid 3-Nitrobenzoic acid 2-Nitrobenzoic acid 4-(Trifluoromethyl)benzoic acid 4-Nitrobenzoic acid NITROGEN DIOXIDE p-Toluic acid 2-Nitrobenzyl alcohol 3-AMINO-4-METHYLBENZOTRIFLUORIDE 2-Nitrobenzaldehyde 2-Amino-4-methylbenzoic acid 4-METHYL-2-NITROBENZOIC ACID 3-Aminobenzotrifluoride 4-(Trifluoromethyl)benzyl alcohol 2,5-Dimethylnitrobenzene 4-Trifluoromethylsalicylic acid 4-(Trifluoromethyl)benzaldehyde

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Nitro-4-(trifluoroMethyl)benzoi

2-Nirto-alpha,alpha,alpha-trifluoro-p-toluylic acid

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2-Nitro-4-(trifluoromethyl)benzoicAcid&gt

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Benzoic acid, 2-nitro-4-(trifluoromethyl)-

320-94-5

C8H4NO4F3

C9H6NO4F3

O2NC6H3CF3CO2H

Carboxylic Acids

Carbonyl Compounds

Organic Building Blocks

Building Blocks

Fluorine series

Aromatics

Miscellaneous Reagents

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid