4,6-DICHLORO-PYRIDIN-3-YLAMINE

Product Name: 4,6-DICHLORO-PYRIDIN-3-YLAMINE
CAS No.: 7321-93-9
Chemical Name: 4,6-DICHLORO-PYRIDIN-3-YLAMINE
Synonyms: 4,6-DICHLOROPYRIDIN-3-AMINE;4,6-Dichloro-3-pyridinamine;2,4-Dichloro-5-aMinopyridine;5-AMINO-2,4-DICHLOROPYRIDINE;3-Pyridinamine, 4,6-dichloro-;4,6-DICHLORO-PYRIDIN-3-YLAMINE;5-Amino-2,4-dichloropyridine 97+%;Pyridine,5-amino-2,4-dichloro- (7CI,8CI);4,6-DICHLORO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH
CBNumber: CB7222007
Molecular Formula: C5H4Cl2N2
Formula Weight: 163
MOL File: 7321-93-9.mol

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4,6-DICHLORO-PYRIDIN-3-YLAMINE Property

Melting point:: 80-81 °C(Solv: ligroine (8032-32-4))
Boiling point:: 290.8±35.0 °C(Predicted)
Density: 1.497±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Powder
pka: 0.72±0.10(Predicted)
color: Pale brown
InChI: InChI=1S/C5H4Cl2N2/c6-3-1-5(7)9-2-4(3)8/h1-2H,8H2
InChIKey: FBGVTWONYOCYGA-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=CC(Cl)=C1N

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Safety

RIDADR: UN2811
HazardClass: 6.1
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: A596935
Product name: 5-Amino-2,4-dichloropyridine
Packaging: 1g
Price: $130
Updated: 2021/12/16

TRC

Product number: A596935
Product name: 5-Amino-2,4-dichloropyridine
Packaging: 500mg
Price: $95
Updated: 2021/12/16

TRC

Product number: A596935
Product name: 5-Amino-2,4-dichloropyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD51058
Product name: 4,6-Dichloro-pyridin-3-ylamine
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 116107
Product name: 4,6-Dichloropyridin-3-amine
Purity: >97%
Packaging: 1g
Price: $98
Updated: 2021/12/16

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4,6-DICHLORO-PYRIDIN-3-YLAMINE Chemical Properties,Usage,Production

Uses

4,6-Dichloropyridin-3-amine is an organic amine compound used in the synthesis of 2,4,5-Trichloropyridine and its derivatives. It is also used as a pharmaceutical intermediate component in the preparation of aromatic bridging cyclic amide derivatives for hepatitis B virus infection.

Synthesis

70593-57-6

7321-93-9

The general procedure for the synthesis of 2,4-dichloro-5-aminopyridine from 4,6-dichloropyridin-3-amide was as follows: sodium hydroxide (6.60 g, 165 mmol) was dissolved in water (31 mL) and cooled in an ice bath. Subsequently, bromine (2.08 mL, 40.6 mmol) was added dropwise and the resulting yellow solution was stirred for 15 minutes. A 1,4-dioxane (21 mL) solution of 4,6-dichloronicotinamide (7.27 g, 38.1 mmol) was slowly added dropwise to the above bromine solution over 30 minutes. The reaction mixture was allowed to gradually warm up to 25°C over 18 hours. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure and the remaining solution was diluted with brine and poured into ethyl acetate. The aqueous phase was separated and extracted twice with ethyl acetate. The organic layers were combined, dried with sodium sulfate, decanted and concentrated to give an orange colored oil. The oily substance was purified by passing through a 100 g silica gel fast column using 25% ethyl acetate-hexane as eluent to give 4,6-dichloropyridin-3-ylamine as a brown solid (4.54 g, 73% yield). Finally, 30% aqueous hydrogen peroxide solution (29 mL) was cooled in an ice bath.

References

[1] Patent: US2006/217417, 2006, A1. Location in patent: Page/Page column 13

4,6-DICHLORO-PYRIDIN-3-YLAMINE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Diphenylphosphoryl azide Sodium sulfate Sodium chloride Toluene Trifluoroacetic acid tert-Butanol Triethylamine 4,6-Dichloronicotinic acid Ethyl acetate Sodium bicarbonate Dichloromethane PETROLEUM ETHER

Preparation Products

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4,6-DICHLORO-PYRIDIN-3-YLAMINE Suppliers

China 140 France 1 India 5 United Kingdom 2 United States 17 Global 165

Abblis Chemicals LLC

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View Lastest Price from 4,6-DICHLORO-PYRIDIN-3-YLAMINE manufacturers

Dideu Industries Group Limited

Product: 4,6-DICHLORO-PYRIDIN-3-YLAMINE 7321-93-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 4,6-DICHLORO-PYRIDIN-3-YLAMINE 7321-93-9
Price: US $6.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 10kg ,50kg
Release date: 2020-03-09

7321-93-9, 4,6-DICHLORO-PYRIDIN-3-YLAMINERelated Search:

2-Amino-2',5-dichlorobenzophenone 3,5-DICHLORO-PYRIDIN-4-YLAMINE Fluroxypyr 2,6-DICHLORO-PYRIDIN-4-YLAMINE 2-Amino-3,5-dichloropyridine 5,6-DICHLORO-PYRIDIN-3-YLAMINE 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE 2,4-DICHLORO-5-NITROPYRIDINE 3,5-DICHLORO-4-AMINOPYRIDINE 3,5-DICHLORO-PYRIDIN-4-YLAMINE 4,6-DICHLORO-PYRIDIN-2-YLAMINE 3-Amino-2,6-dichloropyridine-4-carboxylic acid methyl ester 2,5-DICHLORO-PYRIDIN-3-YLAMINE 2,6-Dichloropyridin-3-amine 4,6-DICHLORO-PYRIDIN-3-YLAMINE 2,4,5,6-TETRACHLOROPYRIDIN-3-AMINE 4-Chloro-2,6-dimethyl-3-nitropyridine 1-(3-Amino-2,6-dichloropyridin-4-yl)ethanone ,98% 5,6-DICHLORO-3-AMINO PYRIDINE 5,6-DICHLORO-PYRIDIN-3-YLAMINE

5-AMINO-2,4-DICHLOROPYRIDINE

4,6-DICHLORO-PYRIDIN-3-YLAMINE

4,6-DICHLOROPYRIDIN-3-AMINE

3-Pyridinamine, 4,6-dichloro-

4,6-Dichloro-3-pyridinamine

Pyridine,5-amino-2,4-dichloro- (7CI,8CI)

2,4-Dichloro-5-aMinopyridine

5-Amino-2,4-dichloropyridine 97+%

4,6-DICHLORO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH

7321-93-9

Boronic Acid

Pyridine