ChemicalBook > CAS DataBase List > SC-51322

SC-51322

Product Name
SC-51322
CAS No.
146032-79-3
Chemical Name
SC-51322
Synonyms
SC-51322;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide;8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide;Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide
CBNumber
CB7235197
Molecular Formula
C22H20ClN3O4S
Formula Weight
457.93
MOL File
Mol file
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SC-51322 Property

Melting point:
112-114°C
RTECS 
HQ4002000
storage temp. 
Store at +4°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
6.1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0132
Product name
SC-51322
Purity
≥98% (HPLC)
Packaging
5mg
Price
$40.8
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0132
Product name
SC-51322
Purity
≥98% (HPLC)
Packaging
25mg
Price
$404
Updated
2024/03/01
Alfa Aesar
Product number
J67002
Product name
SC-51322, 98%
Packaging
5mg
Price
$125
Updated
2021/12/16
Cayman Chemical
Product number
10010744
Product name
SC-51322
Purity
≥98%
Packaging
1mg
Price
$20
Updated
2024/03/01
Cayman Chemical
Product number
10010744
Product name
SC-51322
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
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SC-51322 Chemical Properties,Usage,Production

Description

The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 μM.

Chemical Properties

Off-White Solid

Uses

A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects.

storage

Store at -20°C

SC-51322 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC-51322 Suppliers

Canada 1 China 27 India 1 United Kingdom 1 United States 8 Global 38
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
BIOMOL INTERNATIONAL, LP
Tel
--
Fax
--
Email
info@biomol.com
Country
United States
ProdList
1499
Advantage
77

146032-79-3, SC-51322Related Search:

13,14-DIHYDROPROSTAGLANDIN E1 PROSTAGLANDIN F1ALPHA Latanoprost Misoprostol Acid PROSTAGLANDIN D2 Sulprostone PROSTAGLANDIN B1 Fluprostenol Prostaglandin F2a PROSTAGLANDIN A1 PROSTAGLANDIN B2 SC-51089 U-75302 L-161,982 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID 11BETA-PROSTAGL AND IN F2ALPHA LEUKOTRIENE B4 DIMETHYL AMIDE LEUKOTRIENE D4

  • SC-51322
  • 8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide
  • 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide
  • Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide
  • 146032-79-3
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer compounds
  • Pharmaceuticals
  • Sulfur & Selenium Compounds