5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine

Product Name: 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
CAS No.: 870483-87-7
Chemical Name: 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
Synonyms: CS-621;GW2580;SC-203877;GW2580, >=98%;GW2580,GW-2580;SC-203877/GW2580;GW2580 (SC203877);GW2580 (DMSO solution);GW 2580; GW-2580; GW 2580.;cFMS receptor TK inhibitor
CBNumber: CB72510269
Molecular Formula: C20H22N4O3
Formula Weight: 366.41
MOL File: 870483-87-7.mol

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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Property

Boiling point:: 617.5±65.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
form: powder
pka: 7.11±0.10(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 2933.59.8000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1047
Product name: GW 2580
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $103
Updated: 2024/03/01

Sigma-Aldrich

Product number: 344036-M
Product name: cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
Packaging: 1mg
Price: $153
Updated: 2024/03/01

TCI Chemical

Product number: G0504
Product name: GW 2580
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $244
Updated: 2024/03/01

TCI Chemical

Product number: G0504
Product name: GW 2580
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $725
Updated: 2024/03/01

Cayman Chemical

Product number: 15411
Product name: GW 2580
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Chemical Properties,Usage,Production

Description

GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM)1. GW-2580 completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. GW-2580 abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.

Uses

GW2580 has been used to study its effect on paracrine signaling from stretched cardiomyocyte on cardiac fibroblast phenotype.

Biochem/physiol Actions

GW2580 is a cell-permeable, potent and selective ATP-competitive inhibitor of cFMS kinase, receptor for macrophage-colony stimulating factor, M-CSF or CSF-1, and a key regulator of macrophage and osteoclast activation and differentiation. FMS is a type III receptor tyrosine kinase that binds to the macrophage or monocyte colony-stimulating factor (M-CSF or CSF-1). Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states including the growth of metastasis of some types of cancer, in promoting osteoclast proliferation in bone osteolysis, and in several inflammatory disorders. GW2580 selectively inhibits cFMS-mediated cellular functions in vitro at 0.06 μM as well as CSF-1-dependent tumor growth in vivo. GW2580 was inactive against 26 other kinases.

storage

Store at -20°C

References

1) Conway et al. (2005), Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580; Proc. Natl. Acad. Sci. USA, 102 16078 2) Paniagua et al. (2010), c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis; Arthritis Res. Ther., 12 R32

5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

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870483-87-7, 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamineRelated Search:

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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine

GW2580

SC-203877

SC-203877/GW2580

2,4-Pyrimidinediamine, 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-

5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-Pyrimidinediamine

GW 2580; GW-2580; GW 2580.

CS-621

cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine

GW2580, >=98%

cFMS Receptor Tyrosine Kinase Inhibitor

cFMS receptor TK inhibitor

GW2580,GW-2580

5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine USP/EP/BP

GW2580 (SC203877)

GW2580 (DMSO solution)

GW2580 (DMSO solution), cFMS RTK inhibitor

GW 2580, cFMS RTK inhibitor

870483-87-7

Inhibitors