ChemicalBook > CAS DataBase List > O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol

O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol

Product Name: O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
CAS No.: 189209-27-6
Chemical Name: O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
Synonyms: NH2-PEG5-NHBOC;BOC-NH-PEG5-NH2;NHBoc-PEG5-amine;PROTAC Linker 17;Boc-NH-PEG(4)-NH2;NH2-PEG5-C2-NH-Boc;BOC-N-AMIDO-PEG5-NH2;BOC-AMINO-PEG5-AMINE;Boc-N-amido-PEG5-Azide;Boc-N-amido-PEG5-Amine
CBNumber: CB72557907
Molecular Formula: C17H36N2O7
Formula Weight: 380.48
MOL File: 189209-27-6.mol

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O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Property

storage temp.: 2-8°C(protect from light)
solubility: Soluble in Water, DMSO, DCM, DMF
form: Liquid
color: Colorless to light yellow

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A608875
Product name: O-(2-Aminoethyl)-O’-[2-(Boc-amino)ethyl]tetraethyleneGlycol
Packaging: 50mg
Price: $1260
Updated: 2021/12/16

AK Scientific

Product number: 0323AP
Product name: BocNH-PEG5-CH2CH2NH2
Packaging: 5g
Price: $1396
Updated: 2021/12/16

Iris Biotech GmbH

Product number: PEG7890
Product name: Boc-NH-PEG(5)-NH2
Packaging: 5G
Price: $2160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB73001
Product name: BocNH-PEG5-CH2CH2NH2
Packaging: 100mg
Price: $140
Updated: 2021/12/16

ChemPep

Product number: 282409
Product name: Boc-NH-PEG5-CH2CH2NH2
Packaging: 5g
Price: $1200
Updated: 2021/12/16

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O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG5-amine is a Boc protected PEG linker containing an free amino group and5 PEG units. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters. The Boc group can be deprotected under mild acidic conditions to free the amine.

Uses

As a polyethyleneglycol (PEG) derivative, O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol can be used in the preparation of novel biochip technology for detection of explosives-TNT. It is also used as a reagent in the synthesis of chemical inducer of dimeriza tions (CID) to identify the protein target of inhibitors of Toxoplasma gondii invasion.

Synthesis

911209-07-9

189209-27-6

General procedure for the synthesis of tert-butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate from (17-azido-3,6,9,12,15-pentaoxaheptadecyl)carbamate: Compound 6 (5-PEG-Boc-Amino azide, 2.90 g, 8.0 mmol) was dissolved in a Parr reaction flask in 100 ml of ethyl acetate and 0.25 g of 10% Pd/C catalyst was added. The reaction mixture was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was diluted with 200 ml of ethyl acetate and filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to remove the solvent to give 2.41 g of crude product. The crude product was purified by silica gel column chromatography, first eluting using a mixed solvent system of 1% NH4OH/15% MeOH/84% CH2Cl2, and then switching to a mixed solvent system of 1% NH4OH/25% MeOH/74% CH2Cl2, and the target fractions were collected to give 1.37 g of purified product. The purified product was dissolved in toluene and concentrated again under reduced pressure to give 1.21 g (40% yield) of the target compound 7.

IC 50

PEGs; Alkyl/ether

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 586 - 590
[2] Organic and Biomolecular Chemistry, 2009, vol. 7, # 15, p. 3049 - 3060
[3] Synlett, 2015, vol. 26, # 19, p. 2707 - 2713
[4] Patent: US7230101, 2007, B1. Location in patent: Page/Page column 60; 79

O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol manufacturers

LAURENT

Product: BocNH-PEG5-CH2CH2NH2 189209-27-6
Price: US $319.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 500kg
Release date: 2025-11-15

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: tert-butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate 189209-27-6
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

Xian confluore Biological Technology Co., Ltd.

Product: NHBoc-PEG5-amine 189209-27-6
Price: US $0.00/mg
Min. Order: 500mg
Purity: >98.00%
Supply Ability: 500mg
Release date: 2024-04-02

189209-27-6, O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene GlycolRelated Search:

FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Amino-PEG4-acid H2N-PEG8-tBu 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontane-31-thiol N3-PEG3-tBu 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine HO-PEG10-tBu 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) HS-PEG4-tBu 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL α,ω-dipropionic acid tetraethylene glycol DODECAETHYLENE GLYCOL MONOMETHYL ETHER 1,14-diamino-3,6,9,12-tetraoxatetradecane

t-boc-N-amido-PEG6-Amine

t-boc-N-amido-PEG5-Amine

t-boc-N-amido-PEG5-Azide

tert-Butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate

Boc-N-amido-PEG5-Amine

Boc-N-amido-PEG5-Azide

O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol

BocNH-PEG5-CH2CH2NH2

19-AMino-5,8,11,14,17-pentaoxa-2-azanonadecanoic Acid 1,1-DiMethylethyl Ester

Boc-aMino-PEG-aMine (n=5)

Boc-NH-PEG(4)-NH2

Boc-NH-PEG(4)-NH2(19atoMs)

BOC-N-AMIDO-PEG5-NH2

BOC-NH-PEG5-NH2

tert-butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy] ethoxy]ethoxy]ethyl]carbamate

N1-Boc-3,6,9,12,15-pentaoxaheptadecane-1,17-diamine

t-BocNH-PEG5-CH2CH2NH2

NH2-PEG5-C2-NH-Boc

NHBoc-PEG5-amine

BOC-AMINO-PEG5-AMINE

PROTAC Linker 17

5,8,11,14,17-Pentaoxa-2-azanonadecanoic acid, 19-amino-, 1,1-dimethylethyl ester

t-Boc-Amido-PEG6-Amine

BocNH-PEG5-CH2CH2NH2/5,8,11,14,17-Pentaoxa-2-azanonadecanoic acid, 19-amino-, 1,1-dimethylethyl ester

NH2-PEG5-NHBOC

O-(2-Aminoethyl)-O’-[2-(Boc-amino)ethyl]tetraethylene Glycol

O-(2-Aminoethyl)-O′-[2-(Boc-amino)ethyl]tetraethylene Glycol, CAS 189209-27-6

189209-27-6

C17H36N2O7

PEGylation Reagents

Aliphatics

Amines

Intermediates

Polyethyleneglycol Derivatives

peg