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Todralazine hydrochloride

Product Name
Todralazine hydrochloride
CAS No.
3778-76-5
Chemical Name
Todralazine hydrochloride
Synonyms
binazin;binazine;apirachol;ECARAZINE;Apiracohl;Hydrapron;TODRALAZINE HCL;621-bthydrochloride;ECARAZINE HYDROCHLORIDE;TODRALAZINE HYDROCHLORIDE
CBNumber
CB7312164
Molecular Formula
C11H13ClN4O2
Formula Weight
268.7
MOL File
3778-76-5.mol
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
FE2778600
Toxicity
LD50 i.p. in mice: 500 mg/kg (Parravincini)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20893
Product name
Todralazine (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$68
Updated
2021/03/22
Cayman Chemical
Product number
20893
Product name
Todralazine (hydrochloride)
Purity
≥98%
Packaging
500mg
Price
$129
Updated
2021/03/22
Cayman Chemical
Product number
20893
Product name
Todralazine (hydrochloride)
Purity
≥98%
Packaging
1g
Price
$245
Updated
2021/03/22
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Todralazine hydrochloride Chemical Properties,Usage,Production

Originator

Prorazin,Teisan

Uses

Antihypertensor

Manufacturing Process

A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol is cooled, under agitation to a temperature of -10°C. To the suspension is added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in 150 ml of anhydrous ethanol and the reaction mass is agitated for about 2 hours, maintaining a temperature of -10°C. The temperature is then raised to about 20°C and stirring is continued for 2 hours, whereupon heating is applied and boiling is maintained for 15 min. After cooling, the separated 1- hydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water, and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol. 11.5 g of a raw product are obtained which for the purpose of purification are dissolved in 15 ml of boiling water with an addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1- carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are obtained.

Therapeutic Function

Antihypertensive

Todralazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Todralazine hydrochloride Suppliers

Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9686
Advantage
60
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8074
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432-
Fax
0571-87396431
Email
sales@jhechem.com;
Country
China
ProdList
13965
Advantage
53
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9918
Advantage
58
Shanghai Anyinuo Biomedical Technology Co., Ltd.
Tel
021-88888888-
Email
420970979@qq.com
Country
China
ProdList
5481
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-571-88938639
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52932
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11410
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
86-18523575427
Email
sales@conier.com
Country
CHINA
ProdList
47496
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
Email
hongquchem@qq.com
Country
China
ProdList
5134
Advantage
58
Hebei mo Jin biotechnology co., ltd
Tel
Email
angelia@hbmojin.com
Country
China
ProdList
1047
Advantage
58
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44728
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
Email
psaitong@jm-bio.com
Country
China
ProdList
11322
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6928
Advantage
58
Dafeng Tiansheng Pharmaceutical Co., Ltd
Tel
--
Fax
--
Country
China
ProdList
16
Advantage
56
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com;weibochem@163.com
Country
China
ProdList
6187
Advantage
67

3778-76-5, Todralazine hydrochlorideRelated Search:


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