Todralazine hydrochloride

Product Name: Todralazine hydrochloride
CAS No.: 3778-76-5
Chemical Name: Todralazine hydrochloride
Synonyms: binazin;binazine;apirachol;ECARAZINE;Apiracohl;Hydrapron;TODRALAZINE HCL;621-bthydrochloride;ECARAZINE HYDROCHLORIDE;TODRALAZINE HYDROCHLORIDE
CBNumber: CB7312164
Molecular Formula: C11H13ClN4O2
Formula Weight: 268.7
MOL File: 3778-76-5.mol

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Todralazine hydrochloride Property

storage temp.: Store at -20°C
solubility: DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): slightly
form: A crystalline solid
color: White to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
RTECS: FE2778600
Toxicity: LD50 i.p. in mice: 500 mg/kg (Parravincini)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20893
Product name: Todralazine (hydrochloride)
Purity: ≥98%
Packaging: 250mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 20893
Product name: Todralazine (hydrochloride)
Purity: ≥98%
Packaging: 500mg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 20893
Product name: Todralazine (hydrochloride)
Purity: ≥98%
Packaging: 1g
Price: $299
Updated: 2024/03/01

AK Scientific

Product number: O389
Product name: TodralazineHCl
Packaging: 1g
Price: $430
Updated: 2021/12/16

ChemScene

Product number: CS-0098222
Product name: Todralazinehydrochloride
Purity: 98.17%
Packaging: 50mg
Price: $100
Updated: 2021/12/16

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Todralazine hydrochloride Chemical Properties,Usage,Production

Originator

Prorazin,Teisan

Uses

Todralazine Hydrochloride is an antihypertensive agent for research use. Vasodilator.

Uses

Antihypertensor

Manufacturing Process

A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol is cooled, under agitation to a temperature of -10°C. To the suspension is added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in 150 ml of anhydrous ethanol and the reaction mass is agitated for about 2 hours, maintaining a temperature of -10°C. The temperature is then raised to about 20°C and stirring is continued for 2 hours, whereupon heating is applied and boiling is maintained for 15 min. After cooling, the separated 1- hydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water, and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and washed with anhydrous ethanol. 11.5 g of a raw product are obtained which for the purpose of purification are dissolved in 15 ml of boiling water with an addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1- carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are obtained.

Therapeutic Function

Antihypertensive

Todralazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Todralazine hydrochloride Suppliers

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View Lastest Price from Todralazine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Todralazine hydrochloride 3778-76-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-07-15

3778-76-5, Todralazine hydrochlorideRelated Search:

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apirachol

binazin

binazine

carbazicacid,3-(1-phthalazinyl)-,ethylester,monohydrochloride

hydrazinecarboxylicacid,2-(1-phthalazinyl)-,ethylester,monohydrochloride

TODRALAZINE HYDROCHLORIDE

2-(1-PHTHALAZINYL)-HYDRAZINECARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE

ethyl 3-(phthalazin-1-yl)carbazate hydrochloride

ECARAZINE

ECARAZINE HYDROCHLORIDE

TODRALAZINE HCL

Apiracohl

Hydrapron

Todralazine hydrochloride hydrate

ethyl N-(phthalazin-1-ylamino)carbamate hydrochloride

N-(phthalazin-1-ylamino)carbamic acid ethyl ester hydrochloride

ethyl 2-(phthalazin-1-yl)hydrazinecarboxylate hydrochloride

621-bthydrochloride

Todralazine hydrochloride,Ecarazine,Adrenergic Receptor,Inhibitor,inhibit,Todralazine,Beta Receptor

Todralazine hydrochloride, 10 mM in DMSO

3778-76-5

C11H13ClN4O2

C11H12N4O2HCl

C11H11N4O2HCL

Antihypertensive

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