ChemicalBook > CAS DataBase List > 4-Trifluoromethylphenylboronic acid

4-Trifluoromethylphenylboronic acid

Product Name
4-Trifluoromethylphenylboronic acid
CAS No.
128796-39-4
Chemical Name
4-Trifluoromethylphenylboronic acid
Synonyms
4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID;AKOS BRN-0049;17-Dipropionate;RARECHEM AH PB 0095;17-Beta-Estradiol-3;4-Trifluoromethylphe;4-trifluoromethylborate;4-Boronobenzotrifluoride;(4-(trifluoromethyl)phenyl)bor
CBNumber
CB7333758
Molecular Formula
C7H6BF3O2
Formula Weight
189.93
MOL File
128796-39-4.mol
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4-Trifluoromethylphenylboronic acid Property

Melting point:
245-250 °C(lit.)
Boiling point:
258.6±50.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
7.82±0.10(Predicted)
form 
Powder
color 
White
Water Solubility 
Soluble in DMSO, not in water
BRN 
3544189
InChI
InChI=1S/C7H6BF3O2/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4,12-13H
InChIKey
ALMFIOZYDASRRC-UHFFFAOYSA-N
SMILES
B(C1=CC=C(C(F)(F)F)C=C1)(O)O
CAS DataBase Reference
128796-39-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
37/39-26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
439320
Product name
4-(Trifluoromethyl)phenylboronic acid
Purity
≥95.0%
Packaging
1g
Price
$71.7
Updated
2025/07/31
Sigma-Aldrich
Product number
439320
Product name
4-(Trifluoromethyl)phenylboronic acid
Purity
≥95.0%
Packaging
5g
Price
$178
Updated
2025/07/31
TCI Chemical
Product number
T1788
Product name
4-(Trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$60
Updated
2025/07/31
TCI Chemical
Product number
T1788
Product name
4-(Trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$143
Updated
2025/07/31
TCI Chemical
Product number
T1788
Product name
4-(Trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$424
Updated
2025/07/31
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4-Trifluoromethylphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

suzuki reaction

Uses

50

Uses

4-(Trifluoromethyl)phenylboronic Acid is a reactant used in the preparation of alkenyl-substituted cyclopenta[b]indole compounds with antitumor activity.

Synthesis

121-43-7

402-43-7

128796-39-4

[Example 4] In this embodiment, the synthesis of 9-[4-(carbazol-9-yl)phenyl]-10-(4-trifluoromethylphenyl)anthracene (CF3CzPA) represented by structural formula (42) is described. [Step 1] Synthesis of 9-bromo-10-(4-trifluoromethylphenyl)anthracene (i) Synthesis of 4-(trifluoromethyl)phenylboronic acid The synthesis scheme of 4-(trifluoromethylphenylboronic acid) is shown in (E-1). (1) 33 g (0.15 mol) of p-bromobenzotrifluoride was added to a 500 mL three-necked flask under nitrogen protection. Subsequently, 200 mL of tetrahydrofuran (THF) was added and the mixture was stirred. The mixed solution was cooled to -78 °C and 100 mL (0.16 mol) of n-butyllithium (1.6 mol/L) solution was slowly added dropwise through a dropping funnel. After the dropwise addition was completed, stirring was continued for 1 hour by keeping it at -78°C. Then, 22.3 mL (0.20 mol) of trimethyl borate was added and the reaction mixture was gradually warmed to room temperature and stirred for about 12 hours. After the reaction was completed, 100 mL of dilute hydrochloric acid (1 mol/L) was added to the reaction solution and stirring was continued for 1 hour. The aqueous layer was extracted three times with ethyl acetate, the organic layers were combined, washed once with saturated brine and dried with magnesium sulfate. The magnesium sulfate was removed by filtration and the filtrate was concentrated to obtain the solid product. The solid was washed with chloroform to give a final 15 g of white solid target product 4-trifluoromethylphenylboronic acid in 54% yield.

References

[1] Patent: WO2008/26614, 2008, A1. Location in patent: Page/Page column 93-95
[2] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 17, p. 2513 - 2523
[3] Organic and Biomolecular Chemistry, 2012, vol. 10, # 33, p. 6693 - 6704
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 9, p. 1919 - 1922
[5] Journal of Organometallic Chemistry, 2017, vol. 846, p. 305 - 311

4-Trifluoromethylphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Trifluoromethylphenylboronic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Trifluoromethylphenylboronic acid 128796-39-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
Jinan Finer Chemical Co., Ltd
Product
4-Trifluoromethylphenylboronic acid 128796-39-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20mt
Release date
2022-10-10
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
4-Trifluoromethylphenylboronic acid 128796-39-4
Price
US $999.00-800.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-21

128796-39-4, 4-Trifluoromethylphenylboronic acidRelated Search:

4-Tolylboronic acid Benzotrifluoride 3,5-Dimethylphenylboronic acid 3-(Trifluoromethyl)benzoic acid 2-(Trifluoromethyl)benzoic acid Tolyltriazole (Trifluoromethyl)trimethylsilane 3'-(Trifluoromethyl)acetophenone Phenylboronic acid Phenylmethylsulfonyl fluoride 3-（trifluoromethyl) Cinnamaldehyde 3-(Trifluoromethyl)benzaldehyde 4-(Trifluoromethyl)benzaldehyde 1-Bromo-4-(trifluoromethoxy)benzene 4-Aminobenzotrifluoride 4-(Trifluoromethoxy)aniline 4-Trifluoromethylphenol 4-(Trifluoromethyl)benzoic acid

  • P-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
  • RARECHEM AH PB 0095
  • 4-(trifluoromethyl)phchylboronic acid)
  • 4-(Trifluoromethyl)phenylboronic acid,α,α,α-Trifluoro-p-tolylboronic acid, 4-(Trifluoromethyl)benzeneboronic acid
  • 4-Trifluoromethylphe
  • alpha,alpha,alpha-Trifluoro-p-tolueneboronic Acid alpha,alpha,alpha-Trifluoro-p-tolylboronic Acid
  • Boronic acid, B-[4-(trifluoroMethyl)phenyl]-
  • 4-(TrifluoroMethyl)phenylboronic acid >=95.0%
  • α,α,α-Trifluoro-p-tolueneboronic Acid
  • (4-(trifluoromethyl)phenyl)bor
  • 4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
  • 4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID
  • ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUENEBORONIC ACID
  • ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYLBORONIC ACID
  • AKOS BRN-0049
  • α,α,α-Trifluoro-p-tolylboronic acid
  • 4-Trifluoromethylboronic acid
  • 4-(TRIFLUUOROMETHYL)PHENYLBORONICACID
  • 4-(Trifluoromethyl)benzeneboronic acid 98%
  • 4-(TRIFLUOROMETHYL)PHENYLBORIC ACID
  • 4-(Trifluoromethyl)benzeneboronicacid98%
  • 4-Boronobenzotrifluoride
  • 4-TRIFLUOROMETHYLPHENYLBORONIC ACID 98%
  • 4-(Trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
  • α,α,α-Trifluoro-p-tolylboronic acid, 4-(Trifluoromethyl)benzeneboronic acid
  • 4-(Trifluoromethyl)phenylboronic acid ,98%
  • 4-Tirfluromethylphenyl boronic acid
  • 4-trifluoromethylborate
  • 17-Beta-Estradiol-3
  • 17-Dipropionate
  • (2-Bromo-5-methoxy-52-methyl-phenyl)-methano
  • (4-Trifluoromethylphenyl)boronic acid - [T5520]
  • 128796-39-4
  • 98546-11-8
  • 128796-39-5
  • CF3C6H4BOH2
  • BORONIC ACID
  • B (Classes of Boron Compounds)
  • Organometallic Reagents
  • Aryl
  • Boronic Acids and Derivatives
  • Boronic Acids
  • Heterocyclic Compounds
  • Boronic Acid
  • Aryl
  • Halogenated
  • Organoborons
  • Boronic Acids & Esters
  • Phenyls & Phenyl-Het
  • CHIRAL CHEMICALS
  • Boronic Acids & Esters
  • Phenyls & Phenyl-Het
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Substituted Boronic Acids
  • blocks
  • BoronicAcids
  • FluoroCompounds