ChemicalBook > CAS DataBase List > 4-Nitrophenyl chloroformate

4-Nitrophenyl chloroformate

Product Name
4-Nitrophenyl chloroformate
CAS No.
7693-46-1
Chemical Name
4-Nitrophenyl chloroformate
Synonyms
4-NITROPHENYL CARBONOCHLORIDATE;P-NITROPHENYL CHLOROFORMATE;PNPCF;Nitrophenyl chloroforMate;4-Nitrophenyl chloridocarbonate;4-NITROPHENYL CHLOROCARBONATE;PARA-NITROPHENYL CHLOROFORMATE;CHLOROFORMIC ACID P-NITROPHENYL ESTER;CARBONOCHLORIDIC ACID, 4-NITROPHENYL ESTER;p-Nitrophenyl c
CBNumber
CB7348509
Molecular Formula
C7H4ClNO4
Formula Weight
201.56
MOL File
7693-46-1.mol
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4-Nitrophenyl chloroformate Property

Melting point:
77-79 °C(lit.)
Boiling point:
159-162 °C19 mm Hg(lit.)
Density 
1.5719 (rough estimate)
refractive index 
1.6000 (estimate)
Flash point:
>110°C
storage temp. 
2-8°C
solubility 
Soluble in acetone, chloroform, acetone, toluene and benzene.
form 
isopropanol suspension
color 
White to yellow-beige
Water Solubility 
decomposes
Sensitive 
Lachrymatory
BRN 
518127
Stability:
Stable. Incompatible with strong bases, acids. Combustible.
CAS DataBase Reference
7693-46-1(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
EPA Substance Registry System
Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1)
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Safety

Hazard Codes 
C,T,Xi,F
Risk Statements 
34-36/37-23/24/25-41-36/37/38-11-67-36
Safety Statements 
26-36/37/39-45-38-28A-36-16-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
19-21
Hazard Note 
Toxic/Corrosive/Lachrymator
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29159020
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
160210
Product name
4-Nitrophenyl chloroformate
Purity
96%
Packaging
5g
Price
$77.7
Updated
2025/07/31
Sigma-Aldrich
Product number
160210
Product name
4-Nitrophenyl chloroformate
Purity
96%
Packaging
25g
Price
$234
Updated
2025/07/31
TCI Chemical
Product number
C1400
Product name
4-Nitrophenyl Chloroformate
Purity
>98.0%(T)
Packaging
25g
Price
$99
Updated
2025/07/31
TCI Chemical
Product number
C1400
Product name
4-Nitrophenyl Chloroformate
Purity
>98.0%(T)
Packaging
250g
Price
$614
Updated
2025/07/31
Sigma-Aldrich
Product number
160210
Product name
4-Nitrophenyl chloroformate
Purity
96%
Packaging
100g
Price
$545
Updated
2025/07/31
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4-Nitrophenyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

Cream solid

Uses

4-Nitrophenyl chloroformate can be used:

  • As a reagent for the activation of amines, alcohols and thiols.
  • In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
  • In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
  • In the preparation of poly(oxyethylene) modified dextrans.
  • To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.

Uses

4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane. It is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.

Application

4-Nitrophenyl chloroformate is used as:A coupling agent to link the drug molecule with the polyrotaxane carrier molecule.As an activated ester reagent that enables the covalent coupling of a peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate) (OPF).

Description

4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides.

reaction suitability

reaction type: Carbonylations

4-Nitrophenyl chloroformate Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Nitrophenyl chloroformate Suppliers

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View Lastest Price from 4-Nitrophenyl chloroformate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Nitrophenyl chloroformate 7693-46-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Shaanxi Dideu New Materials Co. Ltd
Product
4-Nitrophenyl chloroformate 7693-46-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-19
Henan Fengda Chemical Co., Ltd
Product
4-Nitrophenyl chloroformate 7693-46-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25

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