ChemicalBook > CAS DataBase List > 2-Methoxy-5-sulfamoylbenzoic acid

2-Methoxy-5-sulfamoylbenzoic acid

Product Name
2-Methoxy-5-sulfamoylbenzoic acid
CAS No.
22117-85-7
Chemical Name
2-Methoxy-5-sulfamoylbenzoic acid
Synonyms
Sulpride Impurity D;Sulpiride IMpurity D;Sulpiride EP Impurity D;Sulpiride Impurity D(EP);5-SulfaMoyl-o-anisic Acid;5-sulphamoyl-o-anisic acid;Levosulpiride - EP Impurity D;2-Methoxy-5-sulfamoylbenzoicaci;2-METHOXY-5-SULFONYLBENZOIC ACID;2-METHOXY-5-SULFAMOYLBENZOIC ACID
CBNumber
CB7354418
Molecular Formula
C8H9NO5S
Formula Weight
231.23
MOL File
22117-85-7.mol
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2-Methoxy-5-sulfamoylbenzoic acid Property

Melting point:
220 °C
Boiling point:
482.5±55.0 °C(Predicted)
Density 
1.492±0.06 g/cm3(Predicted)
storage temp. 
Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.56±0.10(Predicted)
color 
White to Off-White
CAS DataBase Reference
22117-85-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
B23698
Product name
2-Methoxy-5-sulfamoylbenzoic acid, 97%
Packaging
10g
Price
$45.65
Updated
2024/03/01
Alfa Aesar
Product number
B23698
Product name
2-Methoxy-5-sulfamoylbenzoic acid, 97%
Packaging
50g
Price
$129.65
Updated
2024/03/01
Alfa Aesar
Product number
B23698
Product name
2-Methoxy-5-sulfamoylbenzoic acid, 97%
Packaging
250g
Price
$459
Updated
2021/12/16
TRC
Product number
M326640
Product name
2-Methoxy-5-sulfamoylbenzoicAcid
Packaging
10g
Price
$180
Updated
2021/12/16
AK Scientific
Product number
J51950
Product name
2-Methoxy-5-sulfamoylbenzoicacid
Packaging
1g
Price
$10
Updated
2021/12/16
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2-Methoxy-5-sulfamoylbenzoic acid Chemical Properties,Usage,Production

Uses

2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).

Preparation

Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.

2-Methoxy-5-sulfamoylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methoxy-5-sulfamoylbenzoic acid manufacturers

Career Henan Chemical Co
Product
2-Methoxy-5-sulfamoylbenzoic acid 22117-85-7
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-21

22117-85-7, 2-Methoxy-5-sulfamoylbenzoic acidRelated Search:

2-Methoxybenzoic acid 4-Methoxybenzoic acid Sulfanilamide p-Anisidine p-Toluenesulfonamide Methoxyacetic acid (Trifluoromethoxy)benzene Anisole EPA p-Anisaldehyde Ascoric Acid Ethyl 2-methoxy-5-sulfamoylbenzoate 2,3-Dimethoxy-5-sulphamoylbenzoic acid 2-METHOXY-5-SULFAMOYLBENZOIC ACID METHYL ESTER 4-Chloro-2-Methoxy-5-Sulfamoylbenzoic Acid Sulpiride Benzonitrile CHEMBRDG-BB 6629596

  • 2-METHOXY-5-SULFAMOYLBENZOIC ACID
  • 2-METHOXY-5-SULFONYLBENZOIC ACID
  • 2-METHOXY-5-SULPHAMOYLBENZOIC ACID
  • 3-CARBOXY-4-METHOXY-BENZENE SULFONAMIDE
  • 2-Methoxy-5-Sufamoyl Benzoic Acid
  • 5-Aminosulfonyl-2-Methoxybenzoic Acid
  • 5-sulphamoyl-o-anisic acid
  • 5-(Aminosulphonyl)-2-methoxybenzoic acid
  • 2-METHOXY-5-SULFONAMIDOBENZOIC ACID
  • 3-Carboxy-4-methoxybenzenesulphonamide
  • 2-Methoxy-5-sulfaMidobenzoic Acid
  • 5-SulfaMoyl-o-anisic Acid
  • 2-METHOXY-5-SULFAMOYLBENZOIC ACIDSULPIRIDE
  • Sulpiride IMpurity D
  • 3-Carboxy-4-methoxybenzenesulphonamide, 5-(Aminosulphonyl)-o-anisic acid
  • 6-methoxy-3-sulfonyl-1-cyclohexa-1,5-dienecarboxylic acid
  • Sulpiride Impurity 4（Sulpiride EP Impurity D）
  • Benzoic acid,5-(aMinosulfonyl)-2-Methoxy-
  • carbazole2-Methoxy-5-sulfamoylbenzoic acid
  • Sulpiride Impurity D(EP)
  • Sulpiride EP Impurity D
  • Levosulpiride - EP Impurity D
  • 5-[(Aminoperoxy)thio]-2-methoxybenzoic Acid
  • 2-Methoxy-5-sulfamoylbenzoicaci
  • Sulpride Impurity D
  • 22117-85-7
  • C8H8NO5S
  • Organic acids
  • Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds