ChemicalBook > CAS DataBase List > BIOTIN-NHS

BIOTIN-NHS

Product Name
BIOTIN-NHS
CAS No.
35013-72-0
Chemical Name
BIOTIN-NHS
Synonyms
NHS-BIOTIN;BIOTIN-OSU;BNHS;2,5-dioxopyrrolidin-1-yl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanoate;(2,5-dioxopyrrolidin-1-yl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate;BHSE;BIOTIN SE;BIOTIN-NHS;D-BIOTIN, SE;NHS-D-BIOTIN
CBNumber
CB7371998
Molecular Formula
C14H19N3O5S
Formula Weight
341.38
MOL File
35013-72-0.mol
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BIOTIN-NHS Property

Melting point:
212-214 °C
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: ≤50 mg/mL Stable for at least one month in dry DMF
form 
powder
pka
13.89±0.40(Predicted)
color 
White to off-white
BRN 
4720781
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
35013-72-0(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10-23
HS Code 
2934 99 90
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1759
Product name
(+)-Biotin N-hydroxysuccinimide ester
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$26.7
Updated
2024/03/01
Sigma-Aldrich
Product number
H1759
Product name
(+)-Biotin N-hydroxysuccinimide ester
Purity
≥98% (HPLC), powder
Packaging
1g
Price
$947
Updated
2024/03/01
Sigma-Aldrich
Product number
8.51023
Product name
Biotin-OSu
Purity
Novabiochem?
Packaging
1g
Price
$254
Updated
2024/03/01
Sigma-Aldrich
Product number
203112
Product name
Biotin-NHS
Packaging
250MG
Price
$401
Updated
2024/03/01
TCI Chemical
Product number
S0491
Product name
N-Succinimidyl D-Biotinate
Purity
>97.0%(HPLC)(N)
Packaging
100mg
Price
$119
Updated
2024/03/01
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BIOTIN-NHS Chemical Properties,Usage,Production

Description

N-Hydroxysuccinimide (NHS) activates carboxylic acid groups (on biotin) to facilitate coupling reactions. Biotin-NHS is a compound used to attach biotin to primary amines under alkaline conditions (pH~8-9). For example, lysines on the surface of proteins, including antibodies, are ideal targets for biotinylation with this compound.

Chemical Properties

White Solid

Uses

amine reactive biotinylation reagent

Uses

Biotin-NHS is used in the biotinylation of proteins and peptides. Couples with primary amine in the pH range 6.5-8.5.

Uses

Amino reactive biotin reagent for preparing biotinylated surfaces or polypeptides.

Purification Methods

Recrystallise the ester from refluxing isoPrOH and dry it in a vacuum over P2O5 + KOH. [Jasiewicz et al. Exp Cell Biol 100 213 1976.]

BIOTIN-NHS Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BIOTIN-NHS manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
BIOTIN-NHS 35013-72-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-09
Xian confluore Biological Technology Co., Ltd.
Product
Biotin-NHS ester 35013-72-0
Price
US $0.00/g
Min. Order
25g
Purity
>95.00%
Supply Ability
25g
Release date
2024-03-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
BIOTIN-NHS 35013-72-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

35013-72-0, BIOTIN-NHSRelated Search:

Sulfo-NHS-Biotin BIOTIN-XX-NHS D-BIOTIN P-NITROPHENYL ESTER Succinimidyl 6-(biotinamido)hexanoate N-Hydroxysuccinimide methyl 5-[(1S,2S,5R)-7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pent anoate BIOTIN HYDRAZIDE (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER Biotin-NHCH2CH2-SS-Pyr Biotin-SLC-NHS Succinimide BIOTIN-NHS DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER 2,5-Dioxopyrrolidin-1-yl octanoate D-DESTHIOBIOTIN D-biotin-d-sulfoxide 7,8-DIAMINOPELARGONIC ACID

  • (+)-biotin-n-hydroxysuccimide ester
  • n-hydroxysuccimidobiotin
  • BIOTIN-OSU: N-HYDROXYSUCCINIMIDOBIOTIN
  • d-Biotin NHS ester
  • (2,5-dioxopyrrolidin-1-yl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
  • 5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER
  • D-(+)BIOTIN N-HYDROXYSUCCINIMIDE ESTER
  • D-BIOTIN-N-HYDROXYSUCCINIMIDE ESTER
  • D-BIOTIN, SE
  • D-BIOTIN, SUCCINIMIDYL ESTER
  • D-BIOTINYL-OSU
  • BNHS
  • BIOTIN-OSU
  • (+)-BIOTIN N-SUCCINIMIDYL ESTER
  • BIOTIN-N-HYDROXYSUCCINIMIDE
  • (+)-BIOTIN-N-HYDROXYSUCCINIMIDE ESTER
  • BIOTIN-N-HYDROXYSUCCINIMIDE ESTER
  • BIOTIN-NHS
  • BIOTIN (LONG ARM) NHS
  • BIOTIN SE
  • BIOTIN SUCCINIMIDYL ESTER
  • BIOTINYL-N-HYDROXY-SUCCINIMIDE
  • (+)-BIOTINYL-N-SUCCINIMIDYL ESTER
  • SUCCINIMIDO-(+)-BIOTIN
  • SUCCINIMIDYL D-BIOTIN
  • N-HYDROXYSUCCINIMIDOBIOTIN
  • NHS-BIOTIN
  • NHS-D-BIOTIN
  • N-SUCCINIMIDYL D-BIOTINATE
  • N-SUCCINIMIDO-(+)-BIOTIN
  • N-Hydroxysuccinimidyl)biotin
  • (+)-Biotin-NHS Ester
  • 2,5-Dioxopyrrolidin-1-yl 5-((3aS,4S,6aR)
  • 2,5-Dioxopyrrolidin-1-yl 5-((3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentano
  • Biotin-OSu Novabiochem
  • Biotin, succinimidyl ester *CAS 35013-72-0*
  • (+)-Biotin-NHS:BIOTIN-NHS
  • N-Hydroxysuccinimido Biotin、BNHS
  • N-Succinimidyl-D-biotin
  • D-Biotin N-Succinimidyl Ester
  • N-(D-Biotinyloxy)succinimide
  • (+)-Biotin N-succinimidyl ester, d-Biotin NHS ester, Biotinyl-N-hydroxy-succinimide, BNHS, N-Hydroxysuccinimidobiotin, N-Succinimidyl D-biotinate, NHS-Biotin
  • 1-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]oxy]-2,5-pyrrolidinedione
  • BHSE
  • (+)-Biotin N-hydroxysuccinimide ester
  • Biotin-NHS N-Hydroxysuccimidobiotin
  • (+)-Biotin N-hydroxysuccinimide ester,(+)-Biotin N-succinimidyl ester, d-Biotin NHS ester, BNHS, Biotinyl-N-hydroxy-succinimide, N-Hydroxysuccinimidobiotin, N-Succinimidyl D-biotinate, NHS-Biotin
  • BIOTIN-NHS (+)-Biotin N-hydroxysucciniMide ester
  • 2,5-dioxopyrrolidin-1-yl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanoate
  • Hexahydro-2-oxo-
  • D-Biotin N-Succinimidyl Ester N-(D-Biotinyloxy)succinimide
  • BNHS, Biotin-NHS
  • BNHS/NHS-Biotin
  • (+)-Biotin N-hydroxysuccinimide ester(Biotin-NHS)
  • 2,5-Dioxo-1-pyrrolidinyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
  • Biotin NHS【2,5-dioxopyrrolidin-1-yl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate】
  • CAS_35013-72-0
  • Biotin-N-succinimidyl