ChemicalBook > CAS DataBase List > Cycloleucine

Cycloleucine

Product Name
Cycloleucine
CAS No.
52-52-8
Chemical Name
Cycloleucine
Synonyms
x201;X 201;cb1639;CYCLEU;CB 1639;nsc1026;wr14997;NSC 1026;WR 14997;wr14,997
CBNumber
CB7376009
Molecular Formula
C6H11NO2
Formula Weight
129.16
MOL File
52-52-8.mol
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Cycloleucine Property

Melting point:
320 °C (dec.) (lit.)
Boiling point:
239.22°C (rough estimate)
Density 
1.1426 (rough estimate)
refractive index 
1.4827 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO: < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)
pka
2.38±0.20(Predicted)
form 
Crystalline Flakes or Powder
color 
White to beige
Water Solubility 
5 g/100 mL
Merck 
14,2734
BRN 
636626
CAS DataBase Reference
52-52-8(CAS DataBase Reference)
NIST Chemistry Reference
Cyclopentanecarboxylic acid, 1-amino-(52-52-8)
EPA Substance Registry System
Cyclopentanecarboxylic acid, 1-amino- (52-52-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22
Safety Statements 
22-24/25
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
GY2625000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29224999
Hazardous Substances Data
52-52-8(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 290mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A48105
Product name
Cycloleucine
Purity
97%
Packaging
10g
Price
$190.8
Updated
2024/03/01
Sigma-Aldrich
Product number
A48105
Product name
Cycloleucine
Purity
97%
Packaging
5g
Price
$203
Updated
2024/03/01
TCI Chemical
Product number
A1063
Product name
1-Aminocyclopentanecarboxylic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
A1063
Product name
1-Aminocyclopentanecarboxylic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$102
Updated
2024/03/01
Alfa Aesar
Product number
B22179
Product name
1-Aminocyclopentanecarboxylic acid, 97+%
Packaging
1g
Price
$30.65
Updated
2024/03/01
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Cycloleucine Chemical Properties,Usage,Production

Chemical Properties

WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER

Uses

NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist

Uses

Cycloleucine can be used as a building block to synthesize:

  • Phosphonylmethylaminocyclopentane-1-carboxylic acid by reacting with paraformaldehyde and diethylphosphite via Kabachnik-Field′s reaction.
  • Benzo[b]thiophene-2-carboxylic acid {1-[1-(R)-(3-morpholin-4-ylpropylcarbamoyl)-2-phenylethylcarbamoyl]cyclopentyl}-amide, (MEN14268) as potential tachykinin NK2 receptor antagonist.

Uses

Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies

Definition

ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.

General Description

Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis.

Purification Methods

Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]

Cycloleucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cycloleucine Suppliers

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View Lastest Price from Cycloleucine manufacturers

Henan Fengda Chemical Co., Ltd
Product
Cycloleucine 52-52-8
Price
US $30.00-0.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cycloleucine 52-52-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cycloleucine 52-52-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

52-52-8, CycloleucineRelated Search:

6-Aminocaproic acid Acetaminophen Cyclopentanecarboxylic acid Tris(hydroxymethyl)aminomethane Cyclopentyl chloride ALTRENOGEST Methylcyclopentane EC 2.6.1.2 Cyclopentane Bromocyclopentane 3-Aminophenol N-CARBOBENZOXY-DL-LEUCINE Glycine 1-Aminocyclopentane-1-carboxylic acid methyl ester hydrochloride Cycloleucine Methyl Ester.HCl,CYCLOLEUCINE METHYL ESTER HCL BOC-CYCLOLEUCINE,N-ALPHA-T-BUTOXYCARBONYL-CYCLOLEUCINE,N-BOC-CYCLOLEUCINE FMOC-CYCLOLEUCINE,N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-CYCLOLEUCINE (1S,3R)-ACPD (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID

  • RARECHEM AK HD C019
  • TIMTEC-BB SBB004230
  • 1-amino-cyclopentanecarboxylicaci
  • Amino-1-cyclopentanecarboxylic acid
  • CB 1639
  • cb1639
  • Cycloleucin
  • Cyclopentanecarboxylic Acid, 1-amino-, L-
  • Cyclopentanecarboxylic acid, L-amino
  • 1-Aminocyclopentanecarboxylate
  • Cyclopentanecarboxylic acid, 1-amino-
  • 1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID, 9 7%
  • 1-Aminocyclopentane-3,3,4,4-D4-1-carboxylic Acid
  • Cycloleucine-carboxyl-13C, 2,2,5-D3
  • 1-Aminocyclo-pentanecarboxylic acid Cycloleucine
  • 1-AMINOCYCLOPENTANCARBOXYLICACID
  • Cycloleucine carboxylic acid
  • 1-Amino-1-cyclopentanecarboxylicacid(Cycloleucine)
  • 1-Carboxycyclopentylamine
  • 1-Aminocyclopentanecarboxylic acid, 97+%
  • H-Cycloleu-OH
  • Cycloleucine,1-Aminocyclopentanecarboxylic acid
  • 1-Amino-1-cyclopenta
  • Cyclolencine
  • NSC 112194
  • NSC 112195
  • NSC 112197
  • 1-AMino-1-cyclopentanecarboxylic acid, 97% 5GR
  • l-cyclopentanecarboxylicaci
  • NSC 1026
  • nsc1026
  • WR 14,997
  • WR 14997
  • wr14,997
  • wr14997
  • X 201
  • x201
  • H-AC5C-OH
  • H-CLE-OH
  • H-NH(1)CPEN-OH
  • CYCLOLEUCINE
  • CYCLEU
  • 1-AMINOCYCLOPENTANE-1-CARBOXYLIC ACID
  • 1-AMINOCYCLOPENTANECARBOXYLIC ACID
  • 1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
  • 1-AMINO-1-CARBOXYCYCLOPENTANE
  • Cycloleucine≥ 98% (HPLC)
  • Irbint-A02
  • 1-Aminocyclopentanecarboxylic Acid &gt
  • Cycloleucine USP/EP/BP
  • Irbesartan Impurity 18
  • Irbesartan Impurity 37
  • TIANFU-CHEM - Cycloleucine
  • Ionotropic glutamate receptors,inhibit,glycine,NMDA,cytostatic,nucleic,Inhibitor,Cycloleucine,methylations,anxiolytic,transferase,iGluR,ATP
  • 52-52-8
  • 1G/瓶[52-52-8
  • 1G/瓶52-52-8
  • H2NC5H8CO2H