ChemicalBook > CAS DataBase List > DIETHYL (BOC-AMINO)MALONATE

DIETHYL (BOC-AMINO)MALONATE

Product Name: DIETHYL (BOC-AMINO)MALONATE
CAS No.: 102831-44-7
Chemical Name: DIETHYL (BOC-AMINO)MALONATE
Synonyms: LABOTEST-BB LT00452467;Diethy (Boc-amino)malonate;DIETHYL (BOC-AMINO)MALONATE;Diethyl 2-(Boc-amino)malonate;Diethyl (Boc-aMino)Malonate,97%;Diethyl (Boc-amino)malonate 97%;(boc-amino)malonic acid diethyl ester;Diethyl (Boc-amino)malonate≥ 99% (GC);DIETHYL (BOC-AMINO)MALONATE USP/EP/BP;Diethyl 2-aminomalonate, N-BOC protected
CBNumber: CB7387140
Molecular Formula: C12H21NO6
Formula Weight: 275.3
MOL File: 102831-44-7.mol

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DIETHYL (BOC-AMINO)MALONATE Property

Boiling point:: 218 °C (lit.)
Density: 1.079 g/mL at 25 °C (lit.)
refractive index: n20/D 1.438(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform, Ethyl Acetate, Methanol
form: Oil
pka: 9.97±0.46(Predicted)
color: Colourless
BRN: 5055305
Stability:: Below-40C
InChI: InChI=1S/C12H21NO6/c1-6-17-9(14)8(10(15)18-7-2)13-11(16)19-12(3,4)5/h8H,6-7H2,1-5H3,(H,13,16)
InChIKey: ULRLHEXGRUWQLQ-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(NC(OC(C)(C)C)=O)C(OCC)=O

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2917198090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 448486
Product name: Diethyl (Boc-amino)malonate
Purity: 97%
Packaging: 25ml
Price: $309
Updated: 2025/07/31

TRC

Product number: D443800
Product name: Diethyl (Boc-amino)malonate
Packaging: 5g
Price: $305
Updated: 2021/12/16

Activate Scientific

Product number: AS44017
Product name: Diethyl 2-(tert-Butoxycarbonylamino)malonate
Purity: 97%
Packaging: 1g
Price: $53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21771
Product name: Diethyl (boc-amino)malonate
Packaging: 5G
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR22746
Product name: Diethyl 2-aminomalonate, N-BOC protected
Packaging: 5g
Price: $87
Updated: 2021/12/16

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DIETHYL (BOC-AMINO)MALONATE Chemical Properties,Usage,Production

Chemical Properties

Colourless Oil

Uses

Diethyl (Boc-amino)malonate (cas# 102831-44-7) is a compound useful in organic synthesis.

Synthesis

6829-40-9

24424-99-5

102831-44-7

Diethyl aminomalonate (17.5 g, 0.1 mol) and triethylamine (20 g, 0.2 mol) were dissolved in 250 mL of dichloromethane in a three-necked flask under ice bath conditions. Subsequently, di-tert-butyl dicarbonate (26 g, 0.12 mol) was slowly added. The reaction mixture was gradually brought to room temperature and stirred continuously at this temperature and the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was extracted with dichloromethane (200 mL × 3). The organic phases were combined, dried with anhydrous magnesium sulfate, and concentrated to give 27 g of the colorless oily product diethyl 2-Boc-aminomalonate in 98% yield.

References

[1] Journal of Organic Chemistry, 1986, vol. 51, # 15, p. 2910 - 2913
[2] Patent: CN106946724, 2017, A. Location in patent: Paragraph 0027; 0028; 0034; 0040
[3] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 12, p. 3973 - 3979
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 9, p. 2909 - 2922
[5] Patent: US2003/65176, 2003, A1

DIETHYL (BOC-AMINO)MALONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DIETHYL (BOC-AMINO)MALONATE manufacturers

Career Henan Chemical Co

Product: Diethyl (Boc-amino)malonate 102831-44-7
Price: US $9.80/KG
Min. Order: 1KG
Purity: ＞98%HPLC
Supply Ability: 20 tons
Release date: 2020-02-06

102831-44-7, DIETHYL (BOC-AMINO)MALONATERelated Search:

Boc-Aminomalonic acid DIETHYL (BOC-AMINO)MALONATE BOC-SER-OH H2O 2-AMINODIETHYLMALONATE Boc-o-methyl-D-serine DIMETHYL (BOC-AMINO)MALONATE BOC-D-ALA-OME Boc-L-serine methyl ester Boc-D-Serine 2-(N-BOC-AMINO)MALONIC ACID MONOETHYL ESTER BOC-D-SER-OME DIETHYL FORMAMIDOMALONATE

LABOTEST-BB LT00452467

DIETHYL (BOC-AMINO)MALONATE

DIETHYL 2-[(TERT-BUTOXYCARBONYL)AMINO]MALONATE

DIETHYL 2-[N-(TERT-BUTOXYCARBONYL)AMINO]MALONATE

(boc-amino)malonic acid diethyl ester

(Boc-amino)malonic acid diethyl ester, Diethyl 2-[N-(tert-butoxycarbonyl)amino]malonate

Diethyl (Boc-aMino)Malonate,97%

Diethyl 2-[(tert-butoxycarbonyl)amino]malonate, Diethyl 2-[(tert-butoxycarbonyl)amino]propane-1,3-dioate

Diethyl 2-aminomalonate, N-BOC protected

Diethyl (Boc-amino)malonate 97%

Diethy (Boc-amino)malonate

Diethyl (Boc-amino)malonate≥ 99% (GC)

Propanedioic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, 1,3-diethyl ester

DIETHYL (BOC-AMINO)MALONATE USP/EP/BP

Diethyl 2-(Boc-amino)malonate

diethyl 2-(tert-butoxycarbonylamino)propanedioate

102831-44-7

CH33COCONHCHCO2CH2CH32

Esters

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C12 to C63

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