3-Bromo-5-methylpyridine
- Product Name
- 3-Bromo-5-methylpyridine
- CAS No.
- 3430-16-8
- Chemical Name
- 3-Bromo-5-methylpyridine
- Synonyms
- 3-brmo-5-me;3-Bromo-5-methyL;5-BROMO-3-PICOLINE;3-BROMO-5-METHYLPY...;3-brmo-5-methylpyridine;3-methy-5-bromopyridine;3-BROMO-5-METHYLPYRIDINE;3-Methyl-5-Bromopyridine;Pyridine, 3-bromo-5-methyl-;3-Bromo-5-methylpyridine >
- CBNumber
- CB7416792
- Molecular Formula
- C6H6BrN
- Formula Weight
- 172.02
- MOL File
- 3430-16-8.mol
3-Bromo-5-methylpyridine Property
- Melting point:
- 16.5-16.7 °C
- Boiling point:
- 110°C/25mmHg(lit.)
- Density
- 1.4869 g/mL at 25 °C
- refractive index
- 1.5618
- Flash point:
- 91 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.16±0.20(Predicted)
- form
- powder to lump to clear liquid
- color
- White or Colorless to Almost white or Almost colorless
- CAS DataBase Reference
- 3430-16-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-22
- Safety Statements
- 26-36/37/39-39
- RIDADR
- NA 1993 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 681245
- Product name
- 3-Bromo-5-methylpyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $128
- Updated
- 2023/06/20
- Product number
- B3724
- Product name
- 3-Bromo-5-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- B3724
- Product name
- 3-Bromo-5-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $166
- Updated
- 2025/07/31
- Product number
- B685580
- Product name
- 5-Bromo-3-picoline
- Packaging
- 25g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- J93718
- Product name
- 3-Bromo-5-methylpyridine
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
3-Bromo-5-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow liquid
Uses
5-Bromo-3-picoline is an intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity
Synthesis
625-92-3
823-96-1
3430-16-8
The general procedure for the synthesis of 3-bromo-5-methylpyridine from 3,5-dibromopyridine and trimethylcyclotriboroxane was as follows: under nitrogen protection, cesium carbonate (1.38 g, 4.22 mmol), trimethylcyclotriboroxane (0.2 mL, 1.47 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.488 g, 0.42 mmol ). Subsequently, a solution of 3,5-dibromopyridine (1.0 g, 4.22 mmol) dissolved in a 9:1 solvent mixture of dioxane and water (10 mL) was added. The reaction mixture was stirred at 110 °C for 16 hours. Upon completion of the reaction, trimethylcyclotriboroxane (0.2 mL, 1.47 mmol) was added again and the reaction temperature was lowered to 100 °C and the reaction continued to be stirred for 16 hours. At the end of the reaction, the reaction mixture was cooled to room temperature, filtered through diatomaceous earth and the filter cake was washed with ethyl acetate. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography with the eluent being a 80:20 solvent mixture of hexane and ethyl acetate, resulting in 3-bromo-5-methylpyridine as a colorless oil (0.654 g, 90% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 2.34 (s, 3H), 7.66 (s, 1H), 8.36 (s, 1H), 8.49 (s, 1H).GC-MS (EI) analysis showed: m/z = 171.0, 173.0 [M].
References
[1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 25
3-Bromo-5-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-5-methylpyridine Suppliers
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- Country
- France
- ProdList
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- Advantage
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- France
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View Lastest Price from 3-Bromo-5-methylpyridine manufacturers
- Product
- 3-Bromo-5-methylpyridine 3430-16-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 3-Bromo-5-methylpyridine 3430-16-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 3-Bromo-5-methylpyridine 3430-16-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26