ChemicalBook > CAS DataBase List > N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

Product Name
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
CAS No.
16357-59-8
Chemical Name
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Synonyms
EEDQ;2-ETHOXY-1-ETHOXYCARBONYL-1,2-DIHYDROQUINOLINE;ethyl 2-ethoxyquinoline-1(2H)-carboxylate;ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate;2-Ethoxy-2H-quinoline-1-carboxylic acid ethyl ester;EEDQ extrapure;2-Ethoxy-1-ethoxycar;LABOTEST-BB LT00440890;EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2;ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECA
CBNumber
CB7436031
Molecular Formula
C14H17NO3
Formula Weight
247.29
MOL File
16357-59-8.mol
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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Property

Melting point:
62-67 °C(lit.)
Boiling point:
125-128 °C (0.1 mmHg)
Density 
1.1173 (rough estimate)
refractive index 
1.5300 (estimate)
Flash point:
125-128°C/0.1mm
storage temp. 
2-8°C
solubility 
Chlorofrom (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
-1.27±0.40(Predicted)
form 
Crystalline Powder
color 
White to beige
Water Solubility 
insoluble
Sensitive 
Moisture Sensitive
Merck 
14,3518
BRN 
533048
CAS DataBase Reference
16357-59-8(CAS DataBase Reference)
EPA Substance Registry System
1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester (16357-59-8)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
38-36/37/38-20/21/22
Safety Statements 
22-24/25-36/37/39-26-36
WGK Germany 
3
RTECS 
VB2010000
F 
9-21
TSCA 
Yes
HS Code 
29334990
Toxicity
mouse,LD50,intraperitoneal,32mg/kg (32mg/kg),Journal of Medicinal Chemistry. Vol. 14, Pg. 49, 1971.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
149837
Product name
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
Purity
≥99%
Packaging
5g
Price
$21.84
Updated
2024/03/01
Sigma-Aldrich
Product number
149837
Product name
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline
Purity
≥99%
Packaging
25g
Price
$70.6
Updated
2024/03/01
TCI Chemical
Product number
E0363
Product name
1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$29
Updated
2024/03/01
Alfa Aesar
Product number
A13724
Product name
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%
Packaging
10g
Price
$32.2
Updated
2024/03/01
Alfa Aesar
Product number
A13724
Product name
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%
Packaging
50g
Price
$90.65
Updated
2024/03/01
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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow solid

Uses

Peptide condensing agent with little or no racemization. Amidation coupling reagent.

Uses

2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is an irreversible membrane-bound receptor antagonist. It is used in synthetic chemistry, discovery, process R&D. It also acts as coupling reagents.

Uses

In the synthesis of peptides.

Purification Methods

Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.]

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline Preparation Products And Raw materials

Raw materials

Quinoline N,N-Dimethylformamide Potassium hydroxide Ethyl chloroformate Boron trifluoride diethyl etherate Diethyl ether Dichloromethane Magnesium sulfate

Preparation Products

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View Lastest Price from N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2022-11-10
Watson Biotechnology Co.,Ltd
Product
EEDQ 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline 16357-59-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-08-22
Henan Aochuang Chemical Co.,Ltd.
Product
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26

16357-59-8, N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinolineRelated Search:

DIETHOXYMETHANE Ethanol Ethoxyquin Ethyl acetate Ethoxyamine hydrochloride Ethylparaben Ethyl acrylate Ethyl pyruvate Ethyl formate ISOXADIFEN-ETHYL N-PHENYLCARBAMIC ACID METHYL ESTER N-METHYL-N-PHENYLURETHANE ethyl dimethylcarbamate Isobutyl 1,2-dihydro-2-isobutoxy-1-quinoline-carboxylate N,N,2-Trimethylbenzenamine PHENYLURETHANE N-Methylformanilide ethyl (hydroxymethyl)-carbamate

  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline≥ 99% (HPLC)
  • Ethyl 2-ethoxy-1,2-dihydro-1-quinolinecarboxylate for synthesis
  • EEDQ~N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
  • ethyl N-(2-ethoxy-1,2-dihydroquinoline)carboxylate
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline ,98%
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 99+% 100GR
  • ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECA
  • ethyl 2-ethoxyquinoline-1(2H)-carboxylate
  • 2-Ethoxy-1-ethoxycarbonyl-1.2-dihydroquinoline 1g [16357-59-8]
  • 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline,N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, EEDQ, Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate
  • EEDQ, 97+% (2-ETHOXY-1-ETHOXYCARBONYL-1, 2-DIHYDROQUINOLINE)
  • 2-Ethoxy-1-ethoxycar
  • 2-Ethoxy-2H-quinoline-1-carboxylic acid ethyl ester
  • ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate
  • 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline >=99%
  • - ethoxy - 1-2 ethoxy carbonyl - 1, 2 - dihydro quinoline
  • 2-ethoxy-1(2h)-quinolinecarboxylicaciethylester
  • 1,2-Dihydro-2-ethoxy-1-(ethoxycarbonyl)quinoline, Ethyl 2-ethoxyquinoline-1(2H)-carboxylate, EEDQ
  • Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate 97+%
  • EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2
  • EEDQ, 99+%, (2-ETHOXY-1-ETHOXYCARBONYL-1 ,2-DIHYDROQUINOLINE)
  • N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE 99% ( EEDQ)
  • Eedq(2-Ethoxy-1-Ethoxycarbonyl-1,2-Dihydroquinoline)
  • 1,2-Dihydro-2-ethoxy-1-quinolinecarboxylicacidester
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 99+%
  • 1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester
  • ethoxycarbonyl-2-ethoxy-1-2-dlhdroquinoline
  • 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ)
  • EEDQ extrapure
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, EEDQ, Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate
  • Ethyl 2-ethoxy-1(2H)-quinolinecarboxylate
  • Ethyl 2-ethoxy-2H-quinoline-1-carboxylate
  • N-Carbethoxy-2-ethoxy-1,2-dihydroquinoline
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline ,98.3%
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline（EEDQ）
  • 1,2-Dihydro-2-ethoxy-1-quinolinecarboxylic acid ethyl ester
  • LABOTEST-BB LT00440890
  • ETHYL 1,2-DIHYDRO-2-ETHOXY-1-QUINOLINECARBOXYLATE
  • ETHYL 1,2-DIHYDRO-2-ETHOXYQUINOLINE-1-CARBOXYLATE
  • ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECARBOXYLATE
  • EEDQ
  • 2-ETHOXY-1(2H)-QUINOLINECARBOXYLIC ACID ETHYL ESTER
  • 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECARBOXYLIC ACID ETHYL ESTER
  • 2-ETHOXY-1-ETHOXYCARBONYL-1,2-DIHYDROQUINOLINE
  • 1-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE
  • 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline
  • EEDQ, 99+%, (2-ETHOXY-1-ETHOXYCARBONYL-1 ,2-DIHYDROQUINO
  • N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE
  • 1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline&gt
  • EEDQ 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline,99%
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline USP/EP/BP
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
  • 16357-59-8
  • C11H17ON3
  • Condensation & Active Esterification
  • Coupling Reactions (Peptide Synthesis)
  • Peptide Synthesis
  • Others