ChemicalBook > CAS DataBase List > 2-Chloro-5-fluoroaniline

2-Chloro-5-fluoroaniline

Product Name
2-Chloro-5-fluoroaniline
CAS No.
452-83-5
Chemical Name
2-Chloro-5-fluoroaniline
Synonyms
2-CHLORO-5-FLUOROANILINE;5-FLUORO-2-CHLOROANILINE;Chlorofluoroaniline 25---;2-Chloro-5-fluoroaniline97%;2-Chloro-5-fluoroaniline >2-Chloro-5-fluorobenzenamine;2-Chloro-5-fluoroaniline 97%;2-Chloro-5-fluorobenzeneamine;2-CHLORO-5-FLUORO-PHENYLAMINE;Benzenamine, 2-chloro-5-fluoro-
CBNumber
CB7437104
Molecular Formula
C6H5ClFN
Formula Weight
145.56
MOL File
452-83-5.mol
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2-Chloro-5-fluoroaniline Property

Melting point:
26°C
Boiling point:
211°C
Density 
1.349±0.06 g/cm3(Predicted)
refractive index 
1.5560
Flash point:
211°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
clear liquid
pka
1?+-.0.10(Predicted)
color 
Colorless to Light yellow to Light orange
Water Solubility 
Insoluble in water.
FreezingPoint 
17.0 to 22.0 ℃
InChI
InChI=1S/C6H5ClFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
InChIKey
VWUFOZAFKYOZJB-UHFFFAOYSA-N
SMILES
C1(N)=CC(F)=CC=C1Cl
CAS DataBase Reference
452-83-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
20/21/22-36/37/38-23/24/25-22-36/38-33
Safety Statements 
26-36/37/39-45-36/37-28
RIDADR 
UN2811
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C1693
Product name
2-Chloro-5-fluoroaniline
Purity
>98.0%(GC)
Packaging
5g
Price
$34
Updated
2024/03/01
TRC
Product number
C349025
Product name
2-Chloro-5-fluoroaniline
Packaging
5g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
002689
Product name
2-Chloro-5-fluoroaniline
Purity
97%
Packaging
100g
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC64317
Product name
2-Chloro-5-fluoroaniline
Packaging
50g
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC64317
Product name
2-Chloro-5-fluoroaniline
Packaging
250g
Price
$450
Updated
2021/12/16
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2-Chloro-5-fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

Yellowish oily liquid or crystal

Uses

2-Chloro-5-fluoroaniline is used as a pharmaceutical intermediate.

Synthesis

345-17-5

452-83-5

The general procedure for the synthesis of 2-chloro-5-fluoroaniline from 2-chloro-5-fluoronitrobenzene was as follows: a mixture of 0.17 g (1 mmol) of 2-chloro-5-fluoronitrobenzene, 1.13 g (5 mmol) of tin(II) chloride dihydrate, and 10 mL of ethanol was stirred for 0.5 hours at 70 °C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into 30 mL of water, alkalized with 10% sodium carbonate solution and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness to give 0.12 g (84.5% yield) of the target product 2-chloro-5-fluoroaniline. The structure of the product was confirmed by 1H-NMR (CDCl3, δ): 4.16 (single peak, 2H, NH2), 6.51-6.77 (multiple peaks, 2H, CH on the benzene ring), 7.09-7.21 (multiple peaks, 1H, CH on the benzene ring).

References

[1] Patent: EP1200406, 2004, B1. Location in patent: Page 14
[2] Green Chemistry, 2012, vol. 14, # 11, p. 3164 - 3174,11

2-Chloro-5-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-fluoroaniline Suppliers

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View Lastest Price from 2-Chloro-5-fluoroaniline manufacturers

Career Henan Chemical Co
Product
2-Chloro-5-fluoroaniline 452-83-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

452-83-5, 2-Chloro-5-fluoroanilineRelated Search:

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  • 5-FLUORO-2-CHLOROANILINE
  • 2-CHLORO-5-FLUOROANILINE
  • 2-CHLORO-5-FLUORO-PHENYLAMINE
  • 2-Chloro-5-fluorobenzeneamine
  • 2-Chloro-5-fluoroaniline 97%
  • 2-Chloro-5-fluoroaniline97%
  • Chlorofluoroaniline 25---
  • Benzenamine, 2-chloro-5-fluoro-
  • 2-Chloro-5-fluorobenzenamine
  • 2-Chloro-5-fluoroaniline &gt
  • 2-Chloro-5-fluoroaniline ISO 9001：2015 REACH
  • 452-83-5
  • 29214-21-0
  • Anilines, Aromatic Amines and Nitro Compounds
  • Aniline
  • Anilines, Amides & Amines
  • Chlorine Compounds
  • Fluorine Compounds