DIMETHYLPHOSPHINE OXIDE

Product Name: DIMETHYLPHOSPHINE OXIDE
CAS No.: 7211-39-4
Chemical Name: DIMETHYLPHOSPHINE OXIDE
Synonyms: methylphosphonoylmethane;Methylphosphinoylmethane;Einecs 230-591-2;Dimethylphosphinoxid;Dimethyl-Oxophosphonium;DIMETHYLPHOSPHINE OXIDE;imethyl(oxo)phosphanium;DIMETHYLPHOSPHINOUS ACID;dimethyl(oxo)phosphanium;Keto-Dimethyl-Phosphonium
CBNumber: CB7447743
Molecular Formula: C2H7OP
Formula Weight: 78.05
MOL File: 7211-39-4.mol

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DIMETHYLPHOSPHINE OXIDE Property

Boiling point:: 65-67 °C(Press: 6 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: liquid
color: white solid to light yellow
Sensitive: air sensitive
InChI: InChI=1S/C2H7OP/c1-4(2)3/h4H,1-2H3
InChIKey: HGDIHUZVQPKSMO-UHFFFAOYSA-N
SMILES: P(=O)(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Strem Chemicals

Product number: 15-1425
Product name: Dimethylphosphine oxide, min. 95%
Packaging: 500mg
Price: $94
Updated: 2024/03/01

Strem Chemicals

Product number: 15-1425
Product name: Dimethylphosphine oxide, min. 95%
Packaging: 2g
Price: $278
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FD166291
Product name: Dimethylphosphine oxide
Packaging: 10g
Price: $300
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6174-1-01
Product name: Dimethylphosphine oxide
Packaging: 5G
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0315044
Product name: DIMETHYLPHOSPHINE OXIDE
Purity: 95.00%
Packaging: 5MG
Price: $497.68
Updated: 2021/12/16

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DIMETHYLPHOSPHINE OXIDE Chemical Properties,Usage,Production

Description

Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.

Chemical Properties

Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.

Uses

Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer. It is also used as an organic synthetic raw material for the preparation of (α-aminoalkyl)dimethylphosphine oxide enantiomers. Asymmetric synthesis of α-amino-α-polyfluoroalkyl dimethylphosphine oxides was accomplished through diastereoselective addition of dimethylphosphine oxide to enantiomeric Ellman's aldimines, RFCH=NS(O)tert-Bu (RF=CF3, CHF2, PhCF2).

Application

Dimethylphosphine oxide (DMPO) is a hydrogen bonding receptor that can be used to prepare ALK inhibitor compounds (WX-0593) containing DMPO molecules. The results of enzyme assay experiments showed that WX-0593 has high activity against wild-type and mutant ALK, and also inhibits ROS1WT in Ba/F3 cell line very well. In addition, WX-0593 is currently undergoing a phase I/II trial in ALK-positive NSCLC and is expected to be used for the treatment of ROS1-positive NSCLC.

Reactions

Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde. Me2P(O)H+CH2O→Me2P(O)CH2OH Many aldehydes effect a similar reaction.

References

https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en&region=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.

DIMETHYLPHOSPHINE OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIMETHYLPHOSPHINE OXIDE Suppliers

China 149 Germany 1 India 3 Slovakia 1 United Kingdom 2 United States 8 Global 164

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 17777
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Chemiplus Corporation

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Email: okazaki@chemiplus.com
Country: United States
ProdList: 3198
Advantage: 38

Digital Specialty Chemicals, Inc.

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Email: sales@digitalchem.com
Country: United States
ProdList: 710
Advantage: 85

Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

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Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Strem Chemicals, Inc.

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Email: info@strem.com
Country: United States
ProdList: 4910
Advantage: 86

Frontier Scientific, Inc.

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Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

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View Lastest Price from DIMETHYLPHOSPHINE OXIDE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: DIMETHYLPHOSPHINE OXIDE 7211-39-4
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-23

Hebei Weibang Biotechnology Co., Ltd

Product: DIMETHYLPHOSPHINE OXIDE 7211-39-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Puyang Huicheng Electronic Materials Co., Ltd.

Product: Dimethylphosphinoxid 7211-39-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95%
Supply Ability: 20tons
Release date: 2024-05-28

7211-39-4, DIMETHYLPHOSPHINE OXIDERelated Search:

METHYL ISOCYANOACETATE Cupric acetylacetonate Benzyl isocyanide Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) SALCOMINE Tosylmethyl isocyanide Ethyl isocyanoacetate Ferric acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate N-BUTYLISOCYANIDE TERT-BUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) PHENYLSELENOL 2,4-PENTANEDIONE, SILVER DERIVATIVE COBALT(II) ACETYLACETONATE

Methylphosphinoylmethane

DIMETHYLPHOSPHINOUS ACID

DIMETHYLPHOSPHINE OXIDE

Keto-Dimethyl-Phosphonium

Dimethylphosphine Oxide Dimethyl-Oxo-Phosphonium

Dimethyl-Oxophosphonium

Phosphine oxide, dimethyl- (6CI,8CI,9CI)

Einecs 230-591-2

Phosphine oxide, diMethyl-

DIMETHYLPHOSPHINEOXIDE,MIN.95%

Dimethylphosphine oxide, min. 95%

dimethyl(oxo)phosphanium

Dimethylphosphinoxid

methylphosphonoylmethane

imethyl(oxo)phosphanium

7211-39-4

2711-39-4