ChemicalBook > CAS DataBase List > 3-Amino-2-bromo-5-fluoropyridine

3-Amino-2-bromo-5-fluoropyridine

Product Name
3-Amino-2-bromo-5-fluoropyridine
CAS No.
884495-03-8
Chemical Name
3-Amino-2-bromo-5-fluoropyridine
Synonyms
2-bromo-5-fluoropyridin-3-amine;3-Amino-2-bromo-5-fL;2-Bromo-5-fluoro-3-pyridinamine;2-broMo-5-fluoro-3-aMinopyridine;3-AMINO-2-BROMO-5-FLUOROPYRIDINE;3-Pyridinamine, 2-bromo-5-fluoro-;2-Bromo-5-fluoro-pyridin-3-ylamine;3-Amino-2-bromo-5-fluoropyridine,97%;3-Amino-2-bromo-5-fluoropyridine 98%;3-Amino-2-bromo-5-fluoropyridine ISO 9001：2015 REACH
CBNumber
CB7449358
Molecular Formula
C5H4BrFN2
Formula Weight
191
MOL File
884495-03-8.mol
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3-Amino-2-bromo-5-fluoropyridine Property

Melting point:
114-116 °C
Boiling point:
273.6±35.0 °C(Predicted)
Density 
1.813±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
-0.50±0.10(Predicted)
color 
White to off-white
InChI
InChI=1S/C5H4BrFN2/c6-5-4(8)1-3(7)2-9-5/h1-2H,8H2
InChIKey
QUZAKZBKMMUARE-UHFFFAOYSA-N
SMILES
C1(Br)=NC=C(F)C=C1N
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
775800
Product name
3-Amino-2-bromo-5-fluoropyridine
Purity
97%
Packaging
1g
Price
$388
Updated
2023/06/20
TRC
Product number
A595173
Product name
3-Amino-2-bromo-5-fluoropyridine
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105193
Product name
2-bromo-5-fluoropyridin-3-amine
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC48312
Product name
3-Amino-2-bromo-5-fluoropyridine
Purity
98%
Packaging
10g
Price
$208
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105193
Product name
2-bromo-5-fluoropyridin-3-amine
Packaging
10g
Price
$300
Updated
2021/12/16
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3-Amino-2-bromo-5-fluoropyridine Chemical Properties,Usage,Production

Description

3-Amino-2-bromo-5-fluoropyridine is a polyhalogenated pyridine with the chemical formula C5H4BrFN2. The compound has three functional groups: amino, bromine and fluorine, which change its reactivity. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

652160-72-0

884495-03-8

Step 1: A suspension of 2-bromo-5-fluoro-3-nitropyridine (4.42 g, 20 mmol) with stannous chloride (SnCl2, 22.56 g, 100 mmol) in ethanol (EtOH, 40 mL) and concentrated hydrochloric acid (HCl, 40 mL) was heated to 60°C and reacted for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. To the residue was added ethyl acetate (EtOAc, 100 mL) and saturated aqueous sodium bicarbonate (NaHCO3). The mixture was filtered through diatomaceous earth (Celite) and extracted with ethyl acetate (100 mL x 3). The organic layers were combined, washed sequentially with saturated sodium bicarbonate solution, water and brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 3.1 g of 2-bromo-5-fluoropyridin-3-amine as a brown solid (80% yield). Mass spectrum (ESI): m/z = 191.1 [M + 1]+.

References

[1] Patent: WO2013/92940, 2013, A1. Location in patent: Page/Page column 50; 51

3-Amino-2-bromo-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-2-bromo-5-fluoropyridine Suppliers

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View Lastest Price from 3-Amino-2-bromo-5-fluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-Amino-2-bromo-5-fluoropyridine 884495-03-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Career Henan Chemical Co
Product
3-Amino-2-bromo-5-fluoropyridine 884495-03-8
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

884495-03-8, 3-Amino-2-bromo-5-fluoropyridineRelated Search:

Glycine 2-Bromo-5-fluoropyridine Betaine 2-Aminopyridine 1-Hexadecylpyridinium bromide 4-Dimethylaminopyridine 2-Bromo-3-fluoropyridine 3-Aminopyridine 3-Bromoanisole ALTRENOGEST 2-Amino-5-fluoropyridine 3-Amino-2-bromopyridine 2-BROMO-5-FLUORO-3-NITROPYRIDINE 2-AMINO-3-BROMO-5-FLUOROPYRIDINE 3-Amino-5-fluoropyridine 2-BROMO-5-FLUORO-3-NITRO-4-PICOLINE 2,4-DIBROMO-5-FLUORO-3-NITROPYRIDINE 3-AMINO-2,4-DIBROMO-5-FLUOROPYRIDINE

  • 3-AMINO-2-BROMO-5-FLUOROPYRIDINE
  • 2-bromo-5-fluoropyridin-3-amine
  • 2-Bromo-5-fluoro-3-pyridinamine
  • 2-broMo-5-fluoro-3-aMinopyridine
  • 3-Amino-2-bromo-5-fluoropyridine 98%
  • 2-Bromo-5-fluoro-pyridin-3-ylamine
  • 3-Amino-2-bromo-5-fL
  • 3-Pyridinamine, 2-bromo-5-fluoro-
  • 3-Amino-2-bromo-5-fluoropyridine,97%
  • 3-Amino-2-bromo-5-fluoropyridine ISO 9001：2015 REACH
  • 884495-03-8
  • Pyridine
  • Fluorine series