4-Nitro-2-picoline N-oxide

Product Name: 4-Nitro-2-picoline N-oxide
CAS No.: 5470-66-6
Chemical Name: 4-Nitro-2-picoline N-oxide
Synonyms: 4-Nitro-2-picoL;2-methyl-4-nitro-p;4-Nitro-2-picoline N;2-methyl 4-amino N-oxide;Methyl-4-nitropyridine N-;4-Nitro-a-picoline N-oxide;4-NITRO-2-PICOLINE N-OXIDE;2-Methyl-4-nitropyridine1-one;2-Picoline, 4-nitro-, 1-oxide;2-methyl-4-nitro-pyridin1-oxide
CBNumber: CB7453384
Molecular Formula: C6H6N2O3
Formula Weight: 154.12
MOL File: 5470-66-6.mol

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4-Nitro-2-picoline N-oxide Property

Melting point:: 155-159 °C(lit.)
Boiling point:: 277.46°C (rough estimate)
Density: 1.4564 (rough estimate)
refractive index: 1.5100 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO, Methanol
pka: -1.18±0.10(Predicted)
form: powder
color: yellow to light orange
λmax: 333nm(EtOH)(lit.)
BRN: 135501
InChI: InChI=1S/C6H6N2O3/c1-5-4-6(8(10)11)2-3-7(5)9/h2-4H,1H3
InChIKey: FTTIAVRPJGCXAC-UHFFFAOYSA-N
SMILES: C1(C)[N+]([O-])=CC=C([N+]([O-])=O)C=1
CAS DataBase Reference: 5470-66-6(CAS DataBase Reference)
NIST Chemistry Reference: 4-Nitro-2-picoline-n-oxide(5470-66-6)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-40
Safety Statements: 22-26-36
RIDADR: 2811
WGK Germany: 3
RTECS: UT5710000
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 454850
Product name: 2-Methyl-4-nitropyridine N-oxide
Purity: 97%
Packaging: 25g
Price: $332
Updated: 2025/07/31

Sigma-Aldrich

Product number: 454850
Product name: 2-Methyl-4-nitropyridine N-oxide
Purity: 97%
Packaging: 5g
Price: $79.9
Updated: 2023/06/20

TCI Chemical

Product number: M2114
Product name: 2-Methyl-4-nitropyridine N-Oxide
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: M2114
Product name: 2-Methyl-4-nitropyridine N-Oxide
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $228
Updated: 2025/07/31

Usbiological

Product number: M3526-72
Product name: 2-Methyl-4-nitropyridine N-oxide
Packaging: 1g
Price: $403
Updated: 2021/12/16

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4-Nitro-2-picoline N-oxide Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

A nitroheterocyclic compound and its potential suitability as radiosensitizer for cancer radiotherapy.

Reactivity Profile

4-Nitro-2-picoline N-oxide could be used to synthesize 2-Methyl-4-nitro-6-(pyridin-2-yl)pyridine 1-oxide which is a key intermediate of Caerulomycin E and A[1].

Synthesis

931-19-1

5470-66-6

General procedure for the synthesis of 2-methyl-4-nitropyridine-N-oxide from 2-methylpyridine-N-oxide: to a solution containing 2-methylpyridine-N-oxide (4 g, 36.0 mmol), concentrated sulfuric acid (10 mL) was slowly added in a sealed tube. The reaction mixture was stirred at 70°C for 16 hours. The completion of the reaction was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature, quenched with ice-cold water (100 mL) and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was ground with a hexane solution of 10% ethyl acetate (50 mL) to give 2-methyl-4-nitropyridine-N-oxide as a yellow solid. Yield: 4 g (70%); 1H NMR (400 MHz, DMSO-d6): δ 8.41-8.45 (m, 2H), 8.06-8.10 (m, 1H), 2.42 (s, 3H).

References

[1] Zhang, Fang , and X. F. Duan . "Facile one-pot direct arylation and alkylation of nitropyridine N-oxides with Grignard reagents. " Organic Letters 43.13(2012).

4-Nitro-2-picoline N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

4-ACETAMIDOPYRIDINE-2-CARBOXYLIC ACID 4-Bromopyridine-2-carboxylic acid 2-Methyl-4-nitropyridine 4-Aminopyridine-2-carboxylic acid 4-Hydroxy-2-methylpyridine 2-METHYL-4-ACETAMIDOPYRIDINE 4-Hydroxypyridine-2-carboxylic acid 4-Amino-2-picoline 4-Bromo-2-methylpyridine

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4-Nitro-2-picoline N-oxide Suppliers

Americas 1 Canada 1 China 229 Europe 4 France 1 Germany 5 India 34 Japan 3 Jordan 1 Poland 1 Switzerland 4 The Netherlands 1 United Kingdom 20 United States 49 Global 354

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

CHEMOS GmbH & Co. KG

Tel: --
Fax: --
Email: chemos@chemos.de
Country: Germany
ProdList: 6727
Advantage: 58

Service Chemical Inc.

Tel: --
Fax: --
Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

ABCR GmbH & CO. KG

Tel: --
Fax: --
Email: info@abcr.de
Country: Germany
ProdList: 6831
Advantage: 75

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View Lastest Price from 4-Nitro-2-picoline N-oxide manufacturers

Dideu Industries Group Limited

Product: 4-Nitro-2-picoline N-oxide 5470-66-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-08

Career Henan Chemical Co

Product: 4-Nitro-2-picoline N-oxide 5470-66-6
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-02

5470-66-6, 4-Nitro-2-picoline N-oxideRelated Search:

Methylparaben 2-Picoline 4-Nitropyridine N-oxide Pyridine-N-oxide 2,6-Lutidine 2-Chloro-5-chloromethylpyridine 4-Nitropyridine 4-Methylpyridine 2-Picoline-N-oxide 2-Methyl-4-nitropyridine 2,4,6-Collidine METHYL THIOPHENE-2-CARBOXYLATE Methyl acrylate Kresoxim-methyl Bensulfuron methyl Methyl acetate Thiophanate-methyl Methyl

2-Methyl-4-nitropyridine1-one

4-Nitro-2-picoline N-oxide 2-Methyl-4-nitropyridine 1-oxide

2-Methyl-4-nitropyridine <i>N</i>-Oxide

Methyl-4-nitropyridine N-

2- Methyl-4- nitropyridine oxide

2-methyl-4-nitro-pyridin1-oxide

2-Picoline, 4-nitro-, 1-oxide

4-Nitro-2-methylpyridine 1-oxide

4-Nitro-a-picoline N-oxide

Pyridine, 2-methyl-4-nitro-, 1-oxide

4-NITRO-2-METHYLPYRIDINE-N-OXIDE

4-NITRO-2-PICOLINE N-OXIDE

4-NITROPYRIDINE-2-PICOLINE-N-OXIDE

4-Nitropyridine-2-methyl-N-oxide

2-Methyl-4-nitro-1-oxidopyridin-1-ium

4-Nitro-2-picoline-N-oxide ,98%

4-Nitro-2-picoline N

2-Methyl-4-nitropyridine 1-oxide (4-Nitro-2-picoline N-oxide)

2-Methyl-4-nitropyridinium-1-olate, 4-Nitro-2-picoline N-oxide

2-Methyl-4-nitro-1$l^{5}-pyridin-1-one

4-Nitro-2-picoline-N-oxide (2-Methyl-4-nitropyridin-N-oxide)

4-NITRO-2-PICOLINE N-OXIDE (2-METHYL-4-NITROPYRIDINE-N-OXIDE)

2-methyl-4-nitro-p

2-METHYL-4-NITROPYRIDINE 1-OXIDE

2-METHYL-4-NITROPYRIDINE N-OXIDE

2-METHYL-4-NITROPYRIDINIUM-1-OLATE

2-Methyl-4-nitropyridineN-Oxide&gt

4-Nitro-2-picoL

4-Nitro-2-picoline N-oxide ISO 9001：2015 REACH

2-Picoline-4-Nitro pyridine-N-oxide

Pyridine, 2-methyl-4-nitro-, 1-oxide (9CI, ACI)

2-methyl-4-nitro-Pyridine 1-oxide (9CI ACI)

2-methyl 4-amino N-oxide

5470-66-6

Building Blocks

Heterocyclic Building Blocks

Pyridines

C6

Pyridines, Pyrimidines, Purines and Pteredines

Aromatics

Bases & Related Reagents

Nucleotides

Heterocyclic Building Blocks

blocks

NitroCompounds

Pyridines

Pyridine

Aromatics Compounds

Heterocycles

Nitric Oxide Reagents

C6