Tofacitinib Impurity 77

Product Name: Tofacitinib Impurity 77
CAS No.: 1640971-51-2
Chemical Name: Tofacitinib Impurity 77
Synonyms: Tofatinib impurity;Tofatinib Impurity 32;Tofatinib impurity 38;Tofacitinib metabolite-1;Azilsartan medoxomil impurity322;1-Piperidinepropanenitrile, 3-[(6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino]-4-methyl-β-oxo-, (3R,4R)-;3-((3R,4R)-4-methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d] pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
CBNumber: CB74813409
Molecular Formula: C16H20N6O2
Formula Weight: 328.38
MOL File: 1640971-51-2.mol

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Tofacitinib Impurity 77 Property

Boiling point:: 640.4±55.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
pka: 6.05±0.60(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0128276
Product name: Tofacitinibmetabolite-1
Purity: 99.01%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

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Tofacitinib Impurity 77 Chemical Properties,Usage,Production

Uses

Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2].

References

[1] Martin E Dowty, et al. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans. Drug Metab Dispos. 2014 Apr;42(4):759-73. DOI:10.1124/dmd.113.054940
[2] Matthias Gehringer, et al. Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres. ChemMedChem. 2014 Nov;9(11):2516-27. DOI:10.1002/cmdc.201402252

Tofacitinib Impurity 77 Preparation Products And Raw materials

Raw materials

Preparation Products

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Tofacitinib Impurity 77 Suppliers

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1640971-51-2, Tofacitinib Impurity 77Related Search:

Tofacitinib Impurity 2 N-Hydroxysuccinimide CYANOACETIC ACID-OSU (3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine Tofacitinib Benzyl chloride (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Malonyl chloride (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Amino-2,6-dichloropyrimidine N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib Impurity 85 N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine BENZYL ETHYL ETHER 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE 4-(Hydroxyamino)-4-oxobutanoic acid

Tofatinib impurity

3-((3R,4R)-4-methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d] pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

Tofacitinib metabolite-1

1-Piperidinepropanenitrile, 3-[(6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino]-4-methyl-β-oxo-, (3R,4R)-

Azilsartan medoxomil impurity322

Tofatinib impurity 38

Tofatinib Impurity 32

1640971-51-2