Idoxuridine
- Product Name
- Idoxuridine
- CAS No.
- 54-42-2
- Chemical Name
- Idoxuridine
- Synonyms
- IDU;1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-iodopyriMidine-2,4(1H,3H)-dione;ldoxuridine;IUDR;Stoxil;Herplex;DENDRID;Iododeoxyuridine;5-Indo-2ˊ-deoxyuridine;2'-DEOXY-5-IODOURIDINE
- CBNumber
- CB7482614
- Molecular Formula
- C9H11IN2O5
- Formula Weight
- 354.1
- MOL File
- 54-42-2.mol
Idoxuridine Property
- Melting point:
- 194 °C (lit.)
- alpha
- 280 º (c=1,1M NaOH)
- Density
- 1.7911 (estimate)
- refractive index
- 30 ° (C=1, 1mol/L NaOH)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
- form
- Crystalline Powder
- pka
- 8.25(at 25℃)
- color
- White to slightly beige
- Water Solubility
- 1.6 g/L (20 ºC)
- Sensitive
- Air & Light Sensitive
- Merck
- 14,4891
- BRN
- 30397
- InChIKey
- XQFRJNBWHJMXHO-FSDSQADBSA-N
- CAS DataBase Reference
- 54-42-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Uridine, 2'-deoxy-5-iodo-(54-42-2)
- EPA Substance Registry System
- Uridine, 2'-deoxy-5-iodo- (54-42-2)
Safety
- Hazard Codes
- T,Xn
- Risk Statements
- 45-46-61-40-68-62-36/37/38-63
- Safety Statements
- 53-45-36-22-36/37-26
- WGK Germany
- 3
- RTECS
- YU7700000
- F
- 8-23
- TSCA
- Yes
- HS Code
- 29389090
- Hazardous Substances Data
- 54-42-2(Hazardous Substances Data)
- Toxicity
- LD50 i.p. in mice: 2.5 g/kg (Prusoff, 1979)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PHR2884
- Product name
- Idoxuridine
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 500MG
- Price
- $287
- Updated
- 2024/03/01
- Product number
- I7125
- Product name
- 5-Iodo-2′-deoxyuridine
- Purity
- ≥99% (HPLC)
- Packaging
- 5g
- Price
- $373
- Updated
- 2024/03/01
- Product number
- 1336001
- Product name
- Idoxuridine
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 250mg
- Price
- $552
- Updated
- 2024/03/01
- Product number
- I0258
- Product name
- 5-Iodo-2'-deoxyuridine
- Purity
- >99.0%(T)
- Packaging
- 1g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- I0258
- Product name
- 5-Iodo-2'-deoxyuridine
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $133
- Updated
- 2024/03/01
Idoxuridine Chemical Properties,Usage,Production
Description
5-Iodo-2'-deoxyuridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein.
Chemical Properties
Crystalline Solid
Originator
Dendrid,Alcon,US,1963
Uses
Idoxuridine is an antiviral agent effective against herpes-simplex infections; in ophthalmie eyedrops, ointments, and solutions.
Uses
Antiviral;Nucleic acid synthesis inhibitors
Uses
5-Iodo-2'-deoxyuridine is antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.
Definition
ChEBI: A pyrimidine 2'-deoxyribonucleoside compound having 5-iodouracil as the nucleobase; used as an antiviral agent.
Indications
Idoxuridine (Herplex) is a water-soluble iodinated derivative of deoxyuridine that inhibits several DNA viruses including HSV, VZV, vaccinia, and polyoma virus. The triphosphorylated metabolite of idoxuridine inhibits both viral and cellular DNA synthesis and is also incorporated into DNA. Such modified DNA is susceptible to strand breakage and causes aberrant viral protein synthesis. Because of its significant host cytotoxicity, idoxuridine cannot be used to treat systemic viral infections. The development of resistance to this drug is common.
Manufacturing Process
5 g of 5-iodo-uracil (obtained according to T.B. Johnson et al., J. Biol. Chem.
1905/6, 1, 310) in 15 cc of acetic anhydride are heated under reflux for 4,5
hours. The acetylated derivative crystallizes on cooling. The crystallized
product is chilled for ? hour then filtered with suction, washed with acetic
anhydride and then with ether and dried. 4.5 g of 1-acetyl-5-iodo-uracil, MP
167°C, are thus obtained.
1.51 g of mercuric acetate are dissolved in 50 cc of methanol under reflux and
1.35 g of 1-acetyl-5-iodo-uracilare added. A white precipitate is soon formed.
The reaction mixture is kept under reflux for % hour and then allowed to cool to room temperature. The precipitate is then filtered with suction, washed
with methanol and dried.
2.1 g of monomercuric 5-iodo-uracil, MP 280°C, are thus obtained as a
colorless powder, insoluble in water and the majority of the usual organic
solvents, such as benzene, chloroform, alcohol, ether and acetone.
1.46 g of 5-iodo-uracil monomercuric derivative are introduced into 50 cc of
chloroform and 20 to 30 cc of the solvent are distilled off under normal
pressure to ensure good dehydration of the reaction medium. The mixture is
cooled to room temperature and 2.59 g of 3,5-di-p-toluyl-desoxy-Dribofuranosyl chloride added. The mixture is agitated for 6 hours with glass
balls, filtered, rinsed with chloroform and the filtrate is successively washed
with an aqueous sodium iodide solution, with water, with a saturated solution
of sodium bicarbonate and again with water. The product is dried over sodium
sulfate, filtered and evaporated to dryness.
The residue crystallizes in ether and yields about 600 mg of β-3',5'-di-ptoluyl-2'-desoxy-5-iodo-uridine which is recrystallized from toluene. The
product is obtained as colorless crystals, soluble in chloroform and pyridine,
sparingly soluble in acetone, benzene ether and alcohol, insoluble in water, MP
193°C.
206 mg of 3',5'-di-p-toluyl-2'-desoxy-5-iodo-uridineare heated at 80°C with
2.5 cc of caustic soda solution (0.4 N) for ? hour. The solution obtained is
cooled, filtered and then acidified with acetic acid. The desoxy-iodo-uridine
and the p-toluic acid crystallize. Ether is added to dissolve the p-toluic acid,
the mixture is chilled, filtered with suction, washed with water and ether, and
dried. The residue is recrystallized from water and 100 mg of 5-iodo-2'-
desoxy-uridine, are obtained.
brand name
Dendrid (Alcon); Herplex (Allergan); Stoxil (GlaxoSmithKline).
Therapeutic Function
Antiviral (ophthalmic)
Pharmaceutical Applications
A halogenated pyrimidine analog originally synthesized as an
anticancer agent. Formulated in dimethylsulfoxide for topical
application and as a solution for ophthalmic use.
Activity is largely limited to DNA viruses, primarily HSV-1,
HSV-2 and VZV. HSV-1 plaque formation in BHK 21 cells
is sensitive to 6.25–25 mg/L; type 2 microplaques required
62.5–125 mg/L. RNA viruses are not affected, with the exception
of oncogenic RNA viruses such as Rous sarcoma virus.
Drug resistance is easily generated in vitro, and may be an
obstacle to treatment. However, there is little or no crossresistance
with newer nucleoside analogs.
It is poorly soluble in water, and aqueous solutions are
ineffective against infections other than those localized to the
eye. In animals, therapeutic levels are achieved in the cornea
within 30 min of ophthalmic application and persist for 4 h.
Penetration is otherwise poor, with only the biologically inactive
dehalogenated metabolite uracil entering the eye.
The drug is too toxic for systemic administration. Contact
dermatitis, punctate epithelial keratopathy, follicular conjunctivitis,
ptosis, stenosis and occlusion of the puncta and keratinization
of the lid margins occur in up to 14% of those
receiving ophthalmic preparations.
It is used in herpes keratitis, but has largely been superseded
by trifluridine or aciclovir.
Biochem/physiol Actions
5-Iodo-2′-deoxyuridine prevents in vitro DNA viral replication. This is observed in herpesviruses and poxviruses It might possess teratogenic, tumor-promoting, mutagenic, and immunosuppressive properties. 5-Iodo-2′-deoxyuridine, used in topical applications, is effective against epithelial infections.
Mechanism of action
Idoxuridine is a nucleoside containing a halogenated pyrimidine and is an analogue of thymidine. It acts as an antiviral agent against DNA viruses by interfering with their replication based on the similarity of structure between thymidine and idoxuridine. Idoxuridine is first phosphorylated by the host cell virusencoded enzyme thymidine kinase to an active triphosphate form. The phosphorylated drug inhibits cellular DNA polymerase to a lesser extent than HSV DNA polymerase, which is necessary for the synthesis of viral DNA. The triphosphate form of the drug is then incorporated during viral nucleic acid synthesis by a false pairing system that replaces thymidine. When transcription occurs, faulty viral proteins are formed, resulting in defective viral particles.
Clinical Use
The only FDA-approved use of idoxuridine is in the treatment of herpes simplex infections of the eyelid, conjunctiva conjunctiva, and cornea. It is most effective against surface infections because it has little ability to penetrate the tissues of the eye. intravenous idoxuridine was designated an orphan drug for the treatment of soft tissue sarcoma.
Side effects
Idoxuridine may cause local irritation, mild edema, itching, and photophobia. Corneal clouding and small punctate defects in the corneal epithelium have been reported. Allergic reactions are rare.
Safety Profile
Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Iand NOx.
Synthesis
Idoxuridine, 5-iodo-1-(2-deoxyyribofuranosyl)pyrimidin-2,4-(1H.3H)-dione (36.1.14), is synthesized by the following scheme. 5-Iodouracil is acylated with acetic anhydride to make 1-acetyl-5-iodouracil (36.1.11). Treating this with mercury(II) acetate gives 5-iodomonomercury uracil (36.1.12), which is reacted with 1-bromodidesoxy-D-ribofuranosyl-3,5-bis-(p-toluenesulfonate) to make a ditosyl derivative (36.1.13). Hydrolysis of the tosyl groups using sodium hydroxide and subsequent treatment of the resulting substance with acetic acid gives the desired product idoxuridine.
Veterinary Drugs and Treatments
Idoxuridine (IDU) is chemically similar to thymidine and its substitution into viral DNA causes misreading of the viral genetic code thereby inhibiting viral replication. Like trifluridine, IDU is considered virostatic rather than viricidal. IDU was found to be second to trifluridine in efficacy in vitro against common strains of feline herpes virus growing in kidney epithelial cells. IDU is extremely well tolerated in cats and this feature alone makes it the most popular antiviral currently available for use in cats with presumed or established feline herpes virus infection. Although trifluridine was shown to be more effective in vitro, the topical irritation it induces in cats frequently negates any beneficial effect that might be noted clinically. Stinging upon application is a rare feature with IDU/artificial tear preparations.
Metabolism
Idoxuridine is metabolized rapidly in the body to iodouracil, uracil, and iodide. Metabolites are excreted in the urine.
Idoxuridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Idoxuridine manufacturers
- Product
- 5-Iodo-2'-deoxyuridine 54-42-2
- Price
- US $0.00/Kg/Bag
- Min. Order
- 50g
- Purity
- 98%-101%;EP
- Supply Ability
- 10KGS
- Release date
- 2021-07-03
- Product
- (+)-5-iodo-2′-deoxyuridine 54-42-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-09
- Product
- Idoxuridine 54-42-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28