ChemicalBook > CAS DataBase List > 4-Aminoantipyrine

4-Aminoantipyrine

Product Name
4-Aminoantipyrine
CAS No.
83-07-8
Chemical Name
4-Aminoantipyrine
Synonyms
4-AAP;AMPYRONE;AMINOANTIPYRINE;4-AMINOPHENAZONE;4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-AMINOANTIPYRIN;4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE;4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE;NSC 60242;Minoazophene
CBNumber
CB7485059
Molecular Formula
C11H13N3O
Formula Weight
203.24
MOL File
83-07-8.mol
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4-Aminoantipyrine Property

Melting point:
105-110 °C(lit.)
Boiling point:
340 C
Density 
0.8
bulk density
430kg/m3
refractive index 
1.4930 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 0.1 g/mL, clear
pka
pK1: 4.94(+1) (25°C)
form 
Powder or Crystals
color 
Yellow to yellow-brown
PH
7.1 (100g/l, H2O, 20℃)(slurry)
Odor
Odorless
Water Solubility 
ca. 500 g/L (20 ºC)
Merck 
14,591
BRN 
181635
Stability:
Stable. May be light sensitive.
LogP
-0.257 (est)
CAS DataBase Reference
83-07-8(CAS DataBase Reference)
NIST Chemistry Reference
Aminoantipyrene(83-07-8)
EPA Substance Registry System
4-Aminoantipyrene (83-07-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
WGK Germany 
3
RTECS 
CD2480000
F 
8-9-23
Hazard Note 
Harmful
TSCA 
Yes
HS Code 
29331190
Toxicity
LD50 orally in Rabbit: 1700 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33528
Product name
4-Aminoantipyrine
Purity
puriss. p.a., reag. Ph. Eur., ≥99%
Packaging
25g
Price
$95.4
Updated
2025/07/31
Sigma-Aldrich
Product number
33528
Product name
4-Aminoantipyrine
Purity
puriss. p.a., reag. Ph. Eur., ≥99%
Packaging
100g
Price
$102
Updated
2025/07/31
Sigma-Aldrich
Product number
1.07293
Product name
4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Purity
GR for analysis
Packaging
10g
Price
$111
Updated
2025/07/31
Sigma-Aldrich
Product number
06800
Product name
4-Aminoantipyrine
Purity
for spectrophotometric det. of H2O2 and phenols, ≥98.0%
Packaging
25g
Price
$48.5
Updated
2025/07/31
Sigma-Aldrich
Product number
1.07293
Product name
4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Purity
GR for analysis
Packaging
100g
Price
$417
Updated
2025/07/31
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4-Aminoantipyrine Chemical Properties,Usage,Production

Chemical Properties

It is an amber to pale yellow crystalline powder. It is soluble in water, benzene, and ethanol, and only slightly soluble in diethyl ether.

Uses

4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.

Application

4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.

Definition

ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.

Preparation

synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.

General Description

4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.

Purification Methods

It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-Aminoantipyrine Preparation Products And Raw materials

Raw materials

Ammonium bisulfite Iodine solution Sodium nitrite Antipyrine Starch paper Sulfuric acid

Preparation Products

Aminopyrine N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one AMMONIUM ALGINATE
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View Lastest Price from 4-Aminoantipyrine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-Aminoantipyrine 83-07-8
Price
US $2.20-8.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-09
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Aminoantipyrine 83-07-8
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98.0%
Supply Ability
10kg/month
Release date
2021-07-23
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Aminoantipyrine 83-07-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29

83-07-8, 4-AminoantipyrineRelated Search:

Cefazolin sodium salt Cefazolin Chlorodimethylphenylsilane Dimethyl ether Dimethyl fumarate Dimethyl carbonate N,N-Dimethyl-1,4-phenylenediamine Antipyrine Dimethyl sebacate Dimethyl sulfoxide Propyphenazone 4,4'-Diaminodiphenylsulfone N,N-Dimethylformamide Acetaminophen Glucosamine 3,4'-DIAMINODIPHENYLMETHANE DIANTIPYRYLMETHANE EC 2.6.1.2

  • Metamizole EP Impurity B
  • 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one
  • Metamizole Sodium Impurity 2（Minocycline EP Impurity B）
  • 4-aminoantipirine
  • 4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone
  • 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on
  • AKOS BBS-00007964
  • AMINOANTIPYRINE
  • AMINOANTIPYRINE, 4-
  • AMINOANTIPYRINE REAGENT
  • AMINOPHENYZONE
  • AMPYRONE
  • 1-PHENYL-2,3-DIMETHYL-4-AMINOPYRAZOLONE
  • 1,5-DIMETHYL-2-PHENYL-4-AMINOPYRAZOLONE
  • 4-AMINOPHENAZONE
  • 4-AMINOANTIPYRENE
  • 4-AMINOANTIPYRIN
  • 4-AMINOANTIPYRINE
  • 4-AMINOANTIPYRINE REAGENT
  • 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE
  • 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE
  • 4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE
  • 4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE
  • 4-AMINO-1,5-DIMETHYL-2-PHENYL-3H-PYRAZOL-3-ONE
  • 4-Amino-1,5-dimethyl-2-phenyl-3-pyrazolone
  • 1,5-dimethyl-2-phenyl-4-aminopyrazolin
  • 4-AMINOANTIPYRINE [4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE]
  • 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone
  • 1,2-Dihydro-1,5-dimethyl-2-phenyl-4-amino-3H-pyrazol-3-one
  • 1-Phenyl-2,3-dimethyl-4-amino-5-pyrazolone
  • 4-Amino-2,3-dimethyl-1-phenyl-5-pyrazolone
  • 4-Aminoantipyrine [for Biochemical Research]
  • 4-Aminoantipyrine,98%
  • 4-Aminoantipyrine;4-aminophenazone
  • 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYR-AZOL IN-5-ON R. G., REAG. PH. EUR. I
  • 4-AMINOANTIPYRINE FREE BASE
  • 4-AminoantipyrinePuriss
  • 4-AminoantipyrinePuriss(4-Aminophenazone)
  • 4-AMINOBENZENE SULFONIC ACID( Sulphanilic Acid)
  • 4-Amino-1,5-dimethyl-2-phenyl-4-pyrazolin-3-one
  • Aminoantipyrene
  • 4-amino antipyirine
  • 4-AMINOANTIPYRIDINE (AMPYRONE)
  • AMINOANTIPYRINE, 4-(RG)
  • 4-Aminoantipyrine,4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Ampyrone
  • 4-Aminoantipyrine p.a.
  • AMINOANTIPYRINE, 4-(AMPYRONE)(RG)
  • 4-AMINOANTIPYRINERESEARCH GRADE
  • 1,5-Dimethyl-2-phenyl-4-aminopyrazoline
  • 1-Phenyl-2,3-dimethyl-4-aminopyrazloone-[5]
  • 3H-Pyrazol-3-one, 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-
  • 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl-
  • 4-AAP
  • 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 4-Aminophenazone
  • (2,3-Dihydro-1,5-diMethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)aMine
  • Minoazophene
  • NSC 60242
  • (2,3-Dihydro-1,5-(diMethyl-d3)-3-oxo-2-phenyl-1H-pyrazol- 4-yl)aMine