ChemicalBook > CAS DataBase List > 6-Methoxynicotinic acid

6-Methoxynicotinic acid

Product Name: 6-Methoxynicotinic acid
CAS No.: 66572-55-2
Chemical Name: 6-Methoxynicotinic acid
Synonyms: RARECHEM AL BO 0733;6-MethoxynicotinicAci;6-METHOXYNICOTINIC ACID;2-Methoxy-5-pyridinecarboxyL;6-methoxy-3-pyridinecarboxylate;6-Methoxypyridine-3-carboxylic acid;2-METHOXY-5-PYRIDINECARBOXYLIC ACID;2-METHOXYPYRIDINE-5-CARBOXYLIC ACID;6-methoxy-3-pyridinecarboxylic acid;6-Methoxy-pyridin-3-carboxylic acid
CBNumber: CB7491579
Molecular Formula: C7H7NO3
Formula Weight: 153.14
MOL File: 66572-55-2.mol

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6-Methoxynicotinic acid Property

Melting point:: 171.5-172.5 °C(Solv: water (7732-18-5))
Boiling point:: 283.8±20.0 °C(Predicted)
Density: 1.284
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 3.74±0.10(Predicted)
color: Light yellow
CAS DataBase Reference: 66572-55-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M267125
Product name: 2-Methoxy-5-pyridinecarboxylicAcid
Packaging: 25g
Price: $275
Updated: 2021/12/16

TRC

Product number: M267125
Product name: 2-Methoxy-5-pyridinecarboxylicAcid
Packaging: 100g
Price: $910
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021241
Product name: 6-METHOXYNICOTINIC ACID
Purity: 95.00%
Packaging: 25G
Price: $1097.71
Updated: 2021/12/16

Matrix Scientific

Product number: 011264
Product name: 2-Methoxy-5-pyridinecarboxylic acid
Purity: 98%
Packaging: 100g
Price: $165
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021241
Product name: 6-METHOXYNICOTINIC ACID
Purity: 95.00%
Packaging: 5G
Price: $765.3
Updated: 2021/12/16

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6-Methoxynicotinic acid Chemical Properties,Usage,Production

Uses

2-Methoxy-5-pyridinecarboxylic Acid is used in the synthesis of caudatin derivatives as anti-hepatitis B virus agents. In addition it can be used the synthesize potent, selective GSK-3 inhibitors for the use in the treatment of various ailments.

Definition

ChEBI: 6-Methoxy-pyridine-3-carboxylic acid is an aromatic carboxylic acid and a member of pyridines.

Synthesis

26218-80-4

66572-55-2

General procedure for the synthesis of 6-methoxynicotinic acid from methyl 6-methoxynicotinate: sodium hydroxide (0.36 g, 9.0 mmol) was dissolved in a solvent mixture of methanol (5 mL) and water (5 mL). To this solution was added methyl 6-methoxynicotinate (1.00 g, 5.98 mmol), followed by stirring the reaction mixture at 70 °C for 90 minutes. After completion of the reaction, the solution was cooled to room temperature and diluted with 1N sodium hydroxide solution (25 mL). The diluted solution was extracted with ethyl acetate and the aqueous layer was isolated. The aqueous layer was acidified to pH 1 with hydrochloric acid and subsequently extracted three times with ethyl acetate. All organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 6-methoxynicotinic acid as a white solid (0.849 g, 92% yield). Mass spectrometry analysis (APCI positive ion mode) showed m/z 154.1 (100%) (M + H).

References

[1] Patent: WO2008/11131, 2008, A2. Location in patent: Page/Page column 138-139
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 42
[3] Patent: EP1762568, 2007, A1. Location in patent: Page/Page column 40-41
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 227 - 234
[5] Patent: US2003/100576, 2003, A1

6-Methoxynicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Methoxynicotinic acid manufacturers

Dideu Industries Group Limited

Product: 6-Methoxynicotinic acid 66572-55-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-22

Career Henan Chemical Co

Product: 6-Methoxynicotinic acid 66572-55-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

66572-55-2, 6-Methoxynicotinic acidRelated Search:

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6-methoxy-3-pyridinecarboxylic acid

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RARECHEM AL BO 0733

2-METHOXYPYRIDINE-5-CARBOXYLIC ACID

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6-METHOXYNICOTINIC ACID

6-Methoxypyridine-3-carboxylic acid

2-Methoxy-5-pyridinecarboxyL

3-Pyridinecarboxylic acid, 6-methoxy-

6-MethoxynicotinicAci

6-Methoxynicotinic acid ISO 9001：2015 REACH

6-Methoxy-pyridin-3-carboxylic acid

66572-55-2

572-55-2

2621-80-4

Heterocycle-Pyridine series

Acids & Esters

Anisoles, Alkyloxy Compounds & Phenylacetates

Carboxylic Acids

Pyridines

Building Blocks

Pyridine