6-Methoxynicotinic acid
- Product Name
- 6-Methoxynicotinic acid
- CAS No.
- 66572-55-2
- Chemical Name
- 6-Methoxynicotinic acid
- Synonyms
- RARECHEM AL BO 0733;6-MethoxynicotinicAci;6-METHOXYNICOTINIC ACID;2-Methoxy-5-pyridinecarboxyL;6-methoxy-3-pyridinecarboxylate;6-Methoxypyridine-3-carboxylic acid;2-METHOXY-5-PYRIDINECARBOXYLIC ACID;2-METHOXYPYRIDINE-5-CARBOXYLIC ACID;6-methoxy-3-pyridinecarboxylic acid;6-Methoxy-pyridin-3-carboxylic acid
- CBNumber
- CB7491579
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 66572-55-2.mol
6-Methoxynicotinic acid Property
- Melting point:
- 171.5-172.5 °C(Solv: water (7732-18-5))
- Boiling point:
- 283.8±20.0 °C(Predicted)
- Density
- 1.284
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.74±0.10(Predicted)
- color
- Light yellow
- CAS DataBase Reference
- 66572-55-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M267125
- Product name
- 2-Methoxy-5-pyridinecarboxylicAcid
- Packaging
- 25g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- M267125
- Product name
- 2-Methoxy-5-pyridinecarboxylicAcid
- Packaging
- 100g
- Price
- $910
- Updated
- 2021/12/16
- Product number
- OR1913
- Product name
- 6-Methoxynicotinicacid
- Purity
- 98%
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H21-1-Q4
- Product name
- 6-Methoxynicotinic acid
- Purity
- 98%
- Packaging
- 5G
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 011264
- Product name
- 2-Methoxy-5-pyridinecarboxylic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $20
- Updated
- 2021/12/16
6-Methoxynicotinic acid Chemical Properties,Usage,Production
Uses
2-Methoxy-5-pyridinecarboxylic Acid is used in the synthesis of caudatin derivatives as anti-hepatitis B virus agents. In addition it can be used the synthesize potent, selective GSK-3 inhibitors for the use in the treatment of various ailments.
Definition
ChEBI: 6-Methoxy-pyridine-3-carboxylic acid is an aromatic carboxylic acid and a member of pyridines.
Synthesis
26218-80-4
66572-55-2
General procedure for the synthesis of 6-methoxynicotinic acid from methyl 6-methoxynicotinate: sodium hydroxide (0.36 g, 9.0 mmol) was dissolved in a solvent mixture of methanol (5 mL) and water (5 mL). To this solution was added methyl 6-methoxynicotinate (1.00 g, 5.98 mmol), followed by stirring the reaction mixture at 70 °C for 90 minutes. After completion of the reaction, the solution was cooled to room temperature and diluted with 1N sodium hydroxide solution (25 mL). The diluted solution was extracted with ethyl acetate and the aqueous layer was isolated. The aqueous layer was acidified to pH 1 with hydrochloric acid and subsequently extracted three times with ethyl acetate. All organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 6-methoxynicotinic acid as a white solid (0.849 g, 92% yield). Mass spectrometry analysis (APCI positive ion mode) showed m/z 154.1 (100%) (M + H).
References
[1] Patent: WO2008/11131, 2008, A2. Location in patent: Page/Page column 138-139
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 42
[3] Patent: EP1762568, 2007, A1. Location in patent: Page/Page column 40-41
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 227 - 234
[5] Patent: US2003/100576, 2003, A1
6-Methoxynicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-Methoxynicotinic acid Suppliers
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- +91-22-26355700
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- India
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View Lastest Price from 6-Methoxynicotinic acid manufacturers
- Product
- 6-Methoxynicotinic acid 66572-55-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-22
- Product
- 6-Methoxynicotinic acid 66572-55-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-09