PD 169316

ChemicalBook > CAS DataBase List > PD 169316

Product Name: PD 169316
CAS No.: 152121-53-4
Chemical Name: PD 169316
Synonyms: CS-497;PD169317;PD 169316, >97%;PD 169316, >=98%;PD169316(hanDMSO);PD169316/PD-169316;SB-203580 analogue (1);PD 169316 - CAS 152121-53-4 - Calbiochem;4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine;4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
CBNumber: CB7497465
Molecular Formula: C20H13FN4O2
Formula Weight: 360.34
MOL File: 152121-53-4.mol

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PD 169316 Property

Boiling point:: 583.1±50.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
pka: 9.09±0.10(Predicted)
form: solid
color: light orange

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P9248
Product name: PD 169316
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $198
Updated: 2024/03/01

Sigma-Aldrich

Product number: 513030
Product name: PD 169316
Packaging: 1mg
Price: $187
Updated: 2024/03/01

TCI Chemical

Product number: P2532
Product name: PD 169316
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $207
Updated: 2024/03/01

TCI Chemical

Product number: P2532
Product name: PD 169316
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $725
Updated: 2024/03/01

Cayman Chemical

Product number: 10006727
Product name: PD 169316
Purity: >98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

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PD 169316 Chemical Properties,Usage,Production

Description

p38 is a member of the mitogen-activated protein kinase (MAPK) superfamily of enzymes that play an important role in signal transduction. PD 169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC₅₀ of 89 nM, whereas the IC₅₀s are >100-fold higher for extracellular signal-regulated kinase (ERK) and >1,000-fold higher for protein kinase A (PKA) and PKCα. PD 169316 inhibits apoptosis of neuronal and non-neuronal cells deprived of specific trophic factors such as potassium or nerve growth factor.

Uses

PD 169316 is a highly selective, potent inhibitor of p38 MAP kinase. PD 169316 inhibits transforming growth factor β-induced Smad signaling in human ovarian cancer cells. PD 169316 acts as an an endogenous suppressor of apoptosis by mimicking CD9, a membrane tetraspanin. Studies show that PD 169316 reduces myocardial ischemia/reperfusion induced voltage-dependent anion channel(VDAC) phosphorylation

Uses

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

Definition

ChEBI: 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine is a member of imidazoles.

General Description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

Biochem/physiol Actions

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).

in vitro

it was reported that pretreatment of caov3 cells with 10 m pd169316 caused a significant decrease in smad2 and smad3 phosphorylation which was mediated by tgf-β. the inhibitory effect of pd 169316 was proved to act in a dose-dependent manner. study also demonstrated that pd169316 at 5 m or higher dose directly suppressed tgf-β signaling activity. [1]

in vivo

based on an amyloid β (aβ) rat model of alzheimer's disease, the effect of pd 169316 on apoptosis induced by amyloid beta was examined. it was demonstrated that caspase-3 and bax/bcl-2 ratio, two marks of apoptosis, were significantly decreased in the rats pre-treated with pd169316 intracerebroventricularly. this study suggested the potential neuroprotective role of pd 169316 against the neuronal toxicity induced by aβ. [2]

IC 50

a potent, selective and cell-permeable suppressor of p38 map kinase, with the ic50 value of 89 nm.

References

[1]fu yx, o’connor lm, shepherd tg and nachtigal mw. the p38 mapk inhibitor, pd169316, inhibits transforming growth factor β-induced smad signaling in human ovarian cancer cells. biochem bioph res co. 2003. 310: 3917.
[2]ashabi g, alamdary sz, ramin m and khodagholi f. reduction of hippocampal apoptosis by intracerebroventricular administration of extracellular signal-regulated protein kinase and/or p38 inhibitors in amyloid beta rat model of alzheimer’s disease: involvement of nuclear-related factor-2 and nuclear factor-κb. basic clin. pharmacol. toxicol. 2013 aug. 112: 145–55.

PD 169316 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PD 169316 manufacturers

Career Henan Chemical Co

Product: PD 169316 152121-53-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

152121-53-4, PD 169316Related Search:

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PD 169316, >97%

CS-497

PD 169316 - CAS 152121-53-4 - Calbiochem

4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine

Pyridine, 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-5-yl]-

PD169316/PD-169316

4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine

4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine PD 169316

PD 169316 4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine

PD 169316, >=98%

PD169317

PD169316(hanDMSO)

SB-203580 analogue (1)

152121-53-4

C20H13FN4O2

Inhibitors

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators