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PD 169316

Product Name
PD 169316
CAS No.
152121-53-4
Chemical Name
PD 169316
Synonyms
CS-497;PD169317;PD 169316, >97%;PD 169316, >=98%;PD169316(hanDMSO);PD169316/PD-169316;SB-203580 analogue (1);PD 169316 - CAS 152121-53-4 - Calbiochem;4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine;4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
CBNumber
CB7497465
Molecular Formula
C20H13FN4O2
Formula Weight
360.34
MOL File
152121-53-4.mol
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PD 169316 Property

Boiling point:
583.1±50.0 °C(Predicted)
Density 
1.354±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
pka
9.09±0.10(Predicted)
form 
solid
color 
light orange
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P9248
Product name
PD 169316
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$198
Updated
2024/03/01
Sigma-Aldrich
Product number
513030
Product name
PD 169316
Packaging
1mg
Price
$187
Updated
2024/03/01
TCI Chemical
Product number
P2532
Product name
PD 169316
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$207
Updated
2024/03/01
TCI Chemical
Product number
P2532
Product name
PD 169316
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$725
Updated
2024/03/01
Cayman Chemical
Product number
10006727
Product name
PD 169316
Purity
>98%
Packaging
1mg
Price
$62
Updated
2024/03/01
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PD 169316 Chemical Properties,Usage,Production

Description

p38 is a member of the mitogen-activated protein kinase (MAPK) superfamily of enzymes that play an important role in signal transduction. PD 169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC50 of 89 nM, whereas the IC50s are >100-fold higher for extracellular signal-regulated kinase (ERK) and >1,000-fold higher for protein kinase A (PKA) and PKCα. PD 169316 inhibits apoptosis of neuronal and non-neuronal cells deprived of specific trophic factors such as potassium or nerve growth factor.

Uses

PD 169316 is a highly selective, potent inhibitor of p38 MAP kinase. PD 169316 inhibits transforming growth factor β-induced Smad signaling in human ovarian cancer cells. PD 169316 acts as an an endogenous suppressor of apoptosis by mimicking CD9, a membrane tetraspanin. Studies show that PD 169316 reduces myocardial ischemia/reperfusion induced voltage-dependent anion channel(VDAC) phosphorylation

Uses

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

Definition

ChEBI: 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine is a member of imidazoles.

General Description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

Biochem/physiol Actions

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).

in vitro

it was reported that pretreatment of caov3 cells with 10 m pd169316 caused a significant decrease in smad2 and smad3 phosphorylation which was mediated by tgf-β. the inhibitory effect of pd 169316 was proved to act in a dose-dependent manner. study also demonstrated that pd169316 at 5 m or higher dose directly suppressed tgf-β signaling activity. [1]

in vivo

based on an amyloid β (aβ) rat model of alzheimer's disease, the effect of pd 169316 on apoptosis induced by amyloid beta was examined. it was demonstrated that caspase-3 and bax/bcl-2 ratio, two marks of apoptosis, were significantly decreased in the rats pre-treated with pd169316 intracerebroventricularly. this study suggested the potential neuroprotective role of pd 169316 against the neuronal toxicity induced by aβ. [2]

IC 50

a potent, selective and cell-permeable suppressor of p38 map kinase, with the ic50 value of 89 nm.

References

[1]fu yx, o’connor lm, shepherd tg and nachtigal mw. the p38 mapk inhibitor, pd169316, inhibits transforming growth factor β-induced smad signaling in human ovarian cancer cells. biochem bioph res co. 2003. 310: 3917.
[2]ashabi g, alamdary sz, ramin m and khodagholi f. reduction of hippocampal apoptosis by intracerebroventricular administration of extracellular signal-regulated protein kinase and/or p38 inhibitors in amyloid beta rat model of alzheimer’s disease: involvement of nuclear-related factor-2 and nuclear factor-κb. basic clin. pharmacol. toxicol. 2013 aug. 112: 145–55.

PD 169316 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 169316 Suppliers

SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
AXXORA, LLC
Tel
--
Fax
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Email
alexis-ch@alexis-corp.com
Country
Switzerland
ProdList
1104
Advantage
80
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View Lastest Price from PD 169316 manufacturers

Career Henan Chemical Co
Product
PD 169316 152121-53-4
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

152121-53-4, PD 169316Related Search:


  • PD 169316, >97%
  • CS-497
  • PD 169316 - CAS 152121-53-4 - Calbiochem
  • 4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine
  • Pyridine, 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-5-yl]-
  • PD169316/PD-169316
  • 4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
  • 4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine PD 169316
  • PD 169316 4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
  • PD 169316, >=98%
  • PD169317
  • PD169316(hanDMSO)
  • SB-203580 analogue (1)
  • 152121-53-4
  • C20H13FN4O2
  • Inhibitors
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators