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Thymosin α1

Product Name
Thymosin α1
CAS No.
62304-98-7
Chemical Name
Thymosin α1
Synonyms
THYMOSIN A1;THYMOSIN ALPHA 1;ZADAXIN;Thymosin α1 Acetate;Thymosin α1 Acetate;Thymosin α1;Thymosin Alpha;THYMOSIN APHA 1;ThyMosins alpha 1;Thymosina1Acetate
CBNumber
CB7678989
Molecular Formula
C129H215N33O55
Formula Weight
3108.32
MOL File
62304-98-7.mol
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Thymosin α1 Property

Boiling point:
2899.7±65.0 °C(Predicted)
Density 
1.360±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
form 
A crystalline solid
color 
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Stability:
Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
InChI
InChI=1/C129H215N33O55/c1-18-59(10)98(159-114(201)76(36-42-91(181)182)146-120(207)83(53-164)154-121(208)84(54-165)155-127(214)99(63(14)166)160-118(205)80(51-94(187)188)152-123(210)95(56(4)5)156-104(191)62(13)135-102(189)60(11)137-115(202)78(49-92(183)184)151-119(206)82(52-163)138-66(17)169)125(212)161-101(65(16)168)128(215)162-100(64(15)167)126(213)147-70(30-22-26-46-133)109(196)150-79(50-93(185)186)117(204)149-77(47-55(2)3)116(203)142-69(29-21-25-45-132)108(195)144-73(33-39-88(175)176)110(197)141-67(27-19-23-43-130)106(193)140-68(28-20-24-44-131)107(194)145-75(35-41-90(179)180)113(200)157-97(58(8)9)124(211)158-96(57(6)7)122(209)148-74(34-40-89(177)178)111(198)143-71(31-37-86(171)172)105(192)136-61(12)103(190)139-72(32-38-87(173)174)112(199)153-81(129(216)217)48-85(134)170/h55-65,67-84,95-101,163-168H,18-54,130-133H2,1-17H3,(H2,134,170)(H,135,189)(H,136,192)(H,137,202)(H,138,169)(H,139,190)(H,140,193)(H,141,197)(H,142,203)(H,143,198)(H,144,195)(H,145,194)(H,146,207)(H,147,213)(H,148,209)(H,149,204)(H,150,196)(H,151,206)(H,152,210)(H,153,199)(H,154,208)(H,155,214)(H,156,191)(H,157,200)(H,158,211)(H,159,201)(H,160,205)(H,161,212)(H,162,215)(H,171,172)(H,173,174)(H,175,176)(H,177,178)(H,179,180)(H,181,182)(H,183,184)(H,185,186)(H,187,188)(H,216,217)/t59-,60-,61-,62-,63+,64+,65+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,95-,96-,97-,98-,99-,100-,101-/s3
InChIKey
NZVYCXVTEHPMHE-WTRFZTBJNA-N
SMILES
[C@H](CCCCN)(C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)O)CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)C |&1:0,9,18,25,32,41,50,55,64,75,84,93,102,110,118,127,128,134,135,141,142,149,158,164,170,171,177,185,192,197,202,210,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3410
Product name
Thymosin α1 bovine
Purity
≥90% (HPLC)
Packaging
0.5mg
Price
$318
Updated
2024/03/01
Sigma-Aldrich
Product number
T3410
Product name
Thymosin α1 bovine
Purity
≥90% (HPLC)
Packaging
0.1mg
Price
$245
Updated
2023/06/20
Cayman Chemical
Product number
28748
Product name
Thymosin α1 (human, mouse, rat, bovine)
Packaging
500μg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
28748
Product name
Thymosin α1 (human, mouse, rat, bovine)
Packaging
10mg
Price
$869
Updated
2024/03/01
Cayman Chemical
Product number
28748
Product name
Thymosin α1 (human, mouse, rat, bovine)
Packaging
1mg
Price
$137
Updated
2024/03/01
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Thymosin α1 Chemical Properties,Usage,Production

Description

Thymosin-α1 (T-α1), a synthetic 28-amino acid peptide with multiple biological activities primarily directed towards immune response enhancement, this drug is used for the treatment of HBV and hepatitis C virus (HCV) infections, and being developed for the treatment of non-small cell lung cancer (NSCLC), hepatocellular carcinoma, AIDS and malignant melanoma. T-α1 is able to potentiate the action of cytokines and also reduce the hematological toxicity of cytotoxic drug therapy, such as cyclophosphamide, 5-fluorouracil, dacarbazine.

Description

Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo. It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.

Uses

Zadax-in (SciClone).
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function.
Immune enhancing peptide
Helps prevent infections such as the common cold or the flu and diseases
Reduces inflammation in the body
Aids in the removal of acute or chronic infections
Has antibacterial, antiviral, and antifungal properties
Supports the eradication of unhealthy cells
Protects your cells against oxidative stress and damage
Inhibits viral replication
Improve symptoms associated with chronic fatigue
Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections.
https://www.ncbi.nlm.nih.gov

Definition

ChEBI: Thymalfasin is a polypeptide.

Biological Functions

Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
https://www.prospecbio.com

Synthesis Reference(s)

Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can only be chemosynthesized because of two obstacles to its biosynthesis: the difficulties in expressing small peptides and obtaining Nα-acetylation. In this study, we describe a novel production process for Nα-acetylated Tα1 in Escherichia coli.
Synthesis of Thymosin α1, a Polypeptide of the Thymus
Production of Nα-acetylated thymosin α1 in Escherichia coli
Synthesis of thymosin .alpha.1

Clinical claims and research

Thymosin α1 (Tα1) is a 28 amino acid peptide produced by thymic epithelial cellslocated in the outer cortex and medulla of the thymus (Hirokawa et al., 1982).Invitro studies involving the use of bone marrow and progenitor cell cocultures haverevealed Tα1's capacity to stimulate thymocyte maturation (Knutsen et al.,1999).Inaddition，the administration of Tα1 in mice has resulted in notable increases inmurine thymic size and thymocyte numbers，further demonstrating Tal's abilityto enhance thymocyte growth (Beuth et al., 2000).Tα1 is likely to exert its stimula-tory effect on developing thymocytes partly by acting as an anti-apoptotic agent(Baumann et al.，1996). Interestingly，the addition of Tα1 to thymocyte andthymic epithelial cell cocultures was found to increase the production of IL-7 byepithelial cells, suggesting that the enhancing effect of Tal on thymopoiesis may bethrough the induction of IL-7 (Knutsen et al.，1999).
Basic Biology and Clinical Impact of Immunosenescence

Thymosin α1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Thymosin α1 Suppliers

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View Lastest Price from Thymosin α1 manufacturers

Hebei Jiafan Trading Company Limited
Product
Thymosin Alpha-1 62304-98-7
Price
US $15.00/mg
Min. Order
100mg
Purity
99%
Supply Ability
10000000
Release date
2024-12-10
Huaian Banting Trading Co., Ltd.
Product
Thymosin Alpha-1 62304-98-7
Price
US $45.00/box
Min. Order
1box
Purity
99%
Supply Ability
1000box/month
Release date
2024-11-14
Huaian Banting Trading Co., Ltd.
Product
Thymosin Alpha-1 62304-98-7
Price
US $45.00-152.00/Box
Min. Order
1Box
Purity
99%
Supply Ability
1000 boxes
Release date
2024-11-14

62304-98-7, Thymosin α1Related Search:

Thymopentin Eptifibatide Thymosin beta 4 THYMOPENTIN Thymalfasin impurity THYMOPOIETIN II (33-36) THYMOPOIETIN II (34-36) THYMOSIN BETA10 (HUMAN, RAT) Thymosin-β4, Human, Recombinant THYMOPOIETIN II (32-36)-ETHYL ESTER Thymalfasin THYMOSIN ALPHA1 (DEACETYLATED) (HUMAN, BOVINE, MOUSE, RAT) PHENYLSELENOL SALCOMINE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Aluminum acetylacetonate Ethyl isocyanoacetate TERT-BUTYL ISOCYANIDE

  • THYMOSIN ALPHA 1
  • THYMOSIN ALPHA1 BOVINE
  • THYMOSIN APHA 1
  • ZADAXIN
  • Thymosin α1 Acetate
  • Thymosin αAcetate salt
  • Thymalfasin Acetate salt
  • Thymosin α 1 Acetate(Thymalfasin)
  • thymosin α1 bovine
  • AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN: AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
  • Thymosinα1 bovine,Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
  • ThyMosins alpha 1
  • Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH acetate salt
  • Thymosina1Acetate
  • Thymosin α1, Thymalfasin
  • ACETYL-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN
  • AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
  • AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN
  • AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN-OH
  • THYMOSIN A1
  • THYMOSIN A1 BOVINE
  • Thymalfasin/Thymosin α1 Acetate
  • Thymosin α1 (cattle)
  • Thymalfasin (Thymosin α1)
  • Thymosin α1
  • Thymosin α1 (human, mouse, rat, bovine)
  • Thymosin α1(Thymalfasin)
  • Injectable Lyophillzed Powder Peptides Peptide Thymosin Acetate/Thymosin Alpha-1/Thymosin 10mg/Vial
  • Thymosin α1 USP/EP/BP
  • Thymosin α1 Acetate
  • Thymalfasin/Thymosin α1 Acetate
  • alpha 1 Thymosin α1
  • Thymalfasin (Thymosin a1)
  • Thymosin Alpha
  • Thymosin alpha-1/Thymosin α1
  • Thymosin α1 bovine
  • 62304-98-7
  • 162304-98-7
  • C129H215N33O55
  • Peptides
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  • 62304-98-7