ChemicalBook > CAS DataBase List > D-Mannitol

D-Mannitol

Product Name
D-Mannitol
CAS No.
69-65-8
Chemical Name
D-Mannitol
Synonyms
Hexitol;Cordycepic acid;MANNITOL GRANULAR;MANNITE;Mannitol CRS;mannopyranose;mannitose;d-mannito;Resectisol;Bronchitol
CBNumber
CB7720972
Molecular Formula
C6H14O6
Formula Weight
182.17
MOL File
69-65-8.mol
More
Less

D-Mannitol Property

Melting point:
167-170 °C(lit.)
Boiling point:
295°C
alpha 
141 º (c= USP-directives)
Density 
1.52
refractive index 
1.3330 (estimate)
Flash point:
290-295°C/3.5mm
storage temp. 
2-8°C
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Crystalline Powder
pka
13.5(at 18℃)
color 
White
PH
5.0-6.5 (25℃, 1M in H2O)
Odor
at 100.00 %. odorless
Odor Type
odorless
optical activity
[α]25/D +23.3 to +24.3°(lit.)
Water Solubility 
soluble
λmax
λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.04
Merck 
14,5745
BRN 
1721898
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
FBPFZTCFMRRESA-KVTDHHQDSA-N
LogP
-3.262 (est)
CAS DataBase Reference
69-65-8(CAS DataBase Reference)
NIST Chemistry Reference
D-Mannitol(69-65-8)
EPA Substance Registry System
D-Mannitol (69-65-8)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
2
RTECS 
OP2060000
F 
3
Autoignition Temperature
410 °C
TSCA 
Yes
HS Code 
29054300
Hazardous Substances Data
69-65-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 13500 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
NIST920
Product name
D-Mannitol
Purity
NIST? SRM? 920
Packaging
50g
Price
$752
Updated
2024/03/01
Sigma-Aldrich
Product number
MX0214
Product name
Mannitol
Purity
MeetsACSSpecificationsGRACS
Packaging
3kg
Price
$323
Updated
2024/03/01
Sigma-Aldrich
Product number
BP1007
Product name
Mannitol
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
1200MG
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
63560
Product name
D-Mannitol
Purity
ACS reagent, for microbiology, ≥99.0%
Packaging
250g
Price
$54.1
Updated
2024/03/01
Sigma-Aldrich
Product number
63560
Product name
D-Mannitol
Purity
ACS reagent, for microbiology, ≥99.0%
Packaging
1kg
Price
$177
Updated
2024/03/01
More
Less

D-Mannitol Chemical Properties,Usage,Production

Description

Mannitol is a white, crystalline solid consisting of D-mannitol and a small quantity of sorbitol. It is odorless and has a sweet taste. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in most other common organic solvents. It is prepared commercially by catalytic reduction of glucose. Mannitol occurs in small amounts in a variety of foods such as olives, beets, and celery, and in the exudate of certain trees.

Chemical Properties

Mannitol is D-mannitol. It is a hexahydric alcohol related to mannose and is isomeric with sorbitol. D-Mannitol is widespread in plants and plant exudates; obtained from manna and seaweeds. Mannitol occurs as a white, odorless, crystalline powder, or freeflowing granules. It has a sweet taste, approximately as sweet as glucose and half as sweet as sucrose, and imparts a cooling sensation in the mouth. Microscopically, it appears as orthorhombic needles when crystallized from alcohol. Mannitol shows polymorphism.

Originator

Mannitol,MSD,US,1946

Uses

D-Mannitol is used in the food industry as anticaking and free-flow agent, flavo ring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener.
Used in titrimetric determination of boric acid in the manufacture of dry electrolytic condensers for radio applications;
Used in making artificial resins and plasticizers.

Production Methods

Mannitol may be extracted from the dried sap of manna and other natural sources by means of hot alcohol or other selective solvents. It is commercially produced by the catalytic or electrolytic reduction of monosaccharides such as mannose and glucose.

Definition

ChEBI: D-mannitol is the D-enantiomer of mannitol. It has a role as an osmotic diuretic, a sweetening agent, an antiglaucoma drug, a metabolite, an allergen, a hapten, a food bulking agent, a food anticaking agent, a food humectant, a food stabiliser, a food thickening agent, an Escherichia coli metabolite and a member of compatible osmolytes.

Manufacturing Process

250 g of glucose is dissolved in distilled water to give a solution of 48% concentration. This solution is heated to 65°C and barium hydroxide added in quantity sufficient to make the concentration of the barium hydroxide 0.2 mol/liter. The solution is agitated and maintained at 65°C for 6 hours after the addition of the barium hydroxide. It is then cooled and neutralized to a pH of 6.8 with sulfuric acid. The precipitated barium sulfate is filtered out. A quantity of activated supported nickel catalyst containing 5 g of nickel is added.
The slurry is introduced into a 3-liter rocking autoclave, and hydrogen admitted to a pressure of 1,500 psi. The autoclave is heated to a temperature of 150°C in one hour and held at this temperature for 2.5 hours more. Pressure rises to about 1,800 psi and then declines to about 1,600 during the hydrogenation. The autoclave is then cooled, emptied, and the catalyst filtered from the product. The filtrate is then concentrated under vacuum on a hot water bath to remove a part of the water.
The concentrate is taken up in warm aqueous methanol so adjusted that the composition of the solvent is 90% methanol/10% water, and the weight of the solvent is 3 times the weight of the solids in the concentrate. This solution is cooled to 20°C and held overnight. The mannitol which crystallizes is filtered out. The filtrate is concentrated on a water bath under vacuum to remove methanol and adjusted to a water percentage of 16%. The resulting syrup is viscous, noncrystallizing and nongelling, and analysis shows a PN (Pyridine Number) of 32 and essentially no reducing sugar, according to US Patent 2,749,371.

brand name

Osmitrol (Baxter Healthcare); Resectisol (B Braun).

Therapeutic Function

Diuretic, Diagnostic aid (kidney function)

General Description

Odorless white crystalline powder or free-flowing granules. Sweet taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

A sugar alcohol. More closely related to carbohydrates than to other polyhydric alcohols [Noller]. Flammable and/or toxic gases are generated by the combination with alkali metals, nitrides, strong reducing agents and strong oxidizing agents.

Hazard

Mildly toxic; mutagen.

Fire Hazard

D-Mannitol is probably combustible.

Pharmaceutical Applications

Mannitol is widely used in pharmaceutical formulations and food products. In pharmaceutical preparations it is primarily used as a diluent (10–90% w/w) in tablet formulations, where it is of particular value since it is not hygroscopic and may thus be used with moisture-sensitive active ingredients.
Mannitol may be used in direct-compression tablet applications,for which the granular and spray-dried forms are available, or in wet granulations.Granulations containing mannitol have the advantage of being dried easily. Specific tablet applications include antacid preparations, glyceryl trinitrate tablets, and vitamin preparations. Mannitol is commonly used as an excipient in the manufacture of chewable tablet formulations because of its negative heat of solution, sweetness, and ‘mouth feel’.
In lyophilized preparations, mannitol (20–90% w/w) has been included as a carrier to produce a stiff, homogeneous cake that improves the appearance of the lyophilized plug in a vial.A pyrogen-free form is available specifically for this use. Mannitol has also been used to prevent thickening in aqueous antacid suspensions of aluminum hydroxide (<7% w/v). It has been suggested as a plasticizer in soft-gelatin capsules, as a component of sustained-release tablet formulations,and as a carrier in dry powder inhalers.It is also used as a diluent in rapidly dispersing oral dosage forms.It is used in food applications as a bulking agent. Therapeutically, mannitol administered parenterally is used as an osmotic diuretic, as a diagnostic agent for kidney function, as an adjunct in the treatment of acute renal failure, and as an agent to reduce intracranial pressure, treat cerebral edema, and reduce intraocular pressure. Given orally, mannitol is not absorbed significantly from the gastrointestinal tract, but in large doses it can cause osmotic diarrhea;

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Safety

Mannitol is a naturally occurring sugar alcohol found in animals and plants; it is present in small quantities in almost all vegetables. Laxative effects may occur if mannitol is consumed orally in large quantities.If it is used in foods as a bodying agent and daily ingestion of over 20g is foreseeable, the product label should bear the statement ‘excessive consumption may have a laxative effect’. After intravenous injection, mannitol is not metabolized to any appreciable extent and is minimally reabsorbed by the renal tubule, about 80% of a dose being excreted in the urine in 3 hours.
A number of adverse reactions to mannitol have been reported, primarily following the therapeutic use of 20% w/v aqueous intravenous infusions.The quantity of mannitol used as an excipient is considerably less than that used therapeutically and is consequently associated with a lower incidence of adverse reactions. However, allergic, hypersensitive-type reactions may occur when mannitol is used as an excipient.
An acceptable daily intake of mannitol has not been specified by the WHO since the amount consumed as a sweetening agent was not considered to represent a hazard to health.
LD50 (mouse, IP): 14 g/kg
LD50 (mouse, IV): 7.47 g/kg
LD50 (mouse, oral): 22 g/kg
LD50 (rat, IV): 9.69 g/kg
LD50 (rat, oral): 13.5 g/kg

storage

Mannitol is stable in the dry state and in aqueous solutions. Solutions may be sterilized by filtration or by autoclaving and if necessary may be autoclaved repeatedly with no adverse physical or chemical effects.In solution, mannitol is not attacked by cold, dilute acids or alkalis, nor by atmospheric oxygen in the absence of catalysts. Mannitol does not undergo Maillard reactions.
The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

D-Mannitol is crystallised from EtOH, MeOH or H2O and dried at 100o. [Thomson Acta Chem Scand 6 270, 279, 280 1952, Beilstein 1 IV 2841.]

Incompatibilities

Mannitol solutions, 20% w/v or stronger, may be salted out by potassium chloride or sodium chloride.Precipitation has been reported to occur when a 25% w/v mannitol solution was allowed to contact plastic.Sodium cephapirin at 2 mg/mL and 30 mg/mL concentration is incompatible with 20% w/v aqueous mannitol solution. Mannitol is incompatible with xylitol infusion and may form complexes with some metals such as aluminum, copper, and iron. Reducing sugar impurities in mannitol have been implicated in the oxidative degradation of a peptide in a lyophilized formation.Mannitol was found to reduce the oral bioavailability of cimetidine compared to sucrose.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IP, IM, IV, and SC injections; infusions; buccal, oral and sublingual tablets, powders and capsules; ophthalmic preparations; topical solutions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Mon-medicinal Ingredients.

D-Mannitol Preparation Products And Raw materials

Raw materials

Sucrose

Preparation Products

Sodium alginate D-Mannose DIBROMODULCITOL Konjac glucomannan SPINOSAD Spinosad D (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol Dropropizine
More
Less

D-Mannitol Suppliers

Americas 1 Belgium 4 Brazil 3 Canada 7 China 587 Czech Republic 5 Europe 4 France 5 Germany 20 India 49 Japan 10 Mexico 1 Poland 2 Singapore 1 Slovakia 1 Spain 1 Switzerland 4 The Netherlands 1 United Kingdom 26 United States 106 Global 838
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
ProdList
2993
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Allan Chemical Corporation
Tel
--
Fax
--
Email
info@allanchem.com
Country
United States
ProdList
147
Advantage
58
Bruchem, Inc.
Tel
--
Fax
--
Email
sales@bruchem.com
Country
United States
ProdList
576
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
Penta Manufacturing Company (a division of Penta International Corporation)
Tel
--
Fax
--
Email
@pentamfg.com
Country
United States
ProdList
901
Advantage
58
Moravek, Inc.
Tel
--
Fax
--
Email
info@moravek.com
Country
United States
ProdList
279
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
GFS Chemicals, Inc.
Tel
--
Fax
--
Email
Development@gfschemicals.com
Country
United States
ProdList
338
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Beantown Chemical Corporation
Tel
--
Fax
--
Country
United States
ProdList
396
Advantage
58
MP Biomedicals, LLC. (Division of Valiant FC Co., Ltd.)
Tel
--
Fax
--
Email
serv@mpbio.com
Country
United States
ProdList
1854
Advantage
58
SPI PHARMA
Tel
--
Fax
--
Email
gnorman@spipharma.com
Country
United States
ProdList
10
Advantage
58
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
Hestia Laboratories, Inc.
Tel
--
Fax
--
Email
info@hestialabs.com
Country
United States
ProdList
167
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
Cargill Incorporated
Tel
--
Fax
--
Country
United States
ProdList
12
Advantage
58
Charkit Chemical Corporation
Tel
--
Fax
--
Email
sales@charkit.com
Country
United States
ProdList
2993
Advantage
65
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Pfanstiehl, Inc.
Tel
--
Fax
--
Email
cs@pfanstiehl.com
Country
United States
ProdList
13
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
GFS Chemicals Inc
Tel
--
Fax
--
Email
service@gfschemicals.com
Country
United States
ProdList
2329
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
Omicron Biochemicals, Inc.
Tel
--
Fax
--
Email
omicron@omicronbio.com
Country
United States
ProdList
580
Advantage
64
RIA International LLC
Tel
--
Fax
--
Email
marketing@riausa.net
Country
United States
ProdList
1324
Advantage
50
National Biochemicals Corp.
Tel
--
Fax
--
Email
sales@nationalbiochem.com
Country
United States
ProdList
295
Advantage
0
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
srlmarketing@dishnetdsl.net
Country
United States
ProdList
1905
Advantage
64
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
More
Less

View Lastest Price from D-Mannitol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Mannitol 69-65-8
Price
US $0.00/KG
Min. Order
25KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-14
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
D-Mannitol 69-65-8
Price
US $200.00-95.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-27
Hengshui Haoye Co.,Ltd.
Product
Mannitol 69-65-8
Price
US $0.00/Kg/Bag
Min. Order
1T
Purity
99%
Supply Ability
10 tons
Release date
2021-07-17

69-65-8, D-Mannitol Related Search:

D-Mannose TATM D(+)-GLUCOSE MONOHYDRATE Sucrose MANNITOL SALT AGAR METHYL-ALPHA-D-MANNOPYRANOSIDE Kasugamycin hydrochloride Mannitol D-MANNOHEPTULOSE D-Mannitol, 1,2:5,6-bis-O-(1-methylethylidene)-,Isopropylidene-D-Mannitol 2,5-Anhydro-D-mannitol 1,3:4,6-DI-O-BENZYLIDENE-D-MANNITOL 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL Isomannide Isomalt L-MANNITOL 96+% 3,4-O-ISOPROPYLIDENE-D-MANNITOL METHYL 6-O-(ALPHA-D-MANNOPYRANOSYL)-ALPHA-D-MANNOPYRANOSIDE

  • D-Mannitol tested according to Ph.Eur.
  • D-Mannit 0.25
  • invenex
  • Isotol
  • Maniton-S
  • Mannazucker
  • Mannazucker (German)
  • Mannidex
  • Mannigen
  • Mannistol
  • Mannit
  • Mushroom sugar
  • NCI-C50362
  • Osmitrol
  • osmofundin
  • Osmosal
  • Resectisol
  • SDM-25
  • D-Mannitol - EP
  • Mannitol analytical grade
  • d-[UL-13C6:UL-2H8]Mannitol
  • d-[UL-2H8]Mannitol
  • 1,2,3,4,5,6-hexanehexol(mannitol)
  • Cordycepic acid
  • cordycepicacid
  • Mannogem USP, Granular
  • D—Mannit01
  • Manna
  • Mannitolum
  • Sugari
  • D-MannitolGr
  • D-MannitolExtraPure
  • D-Mannitol,98%
  • D-Mannitol,ACS,99.0%min
  • 1,2,3,4,5,6-HEXANEHEXOL
  • MANNITOL, FINE
  • MANNA SUGAR
  • MANNITE
  • MANNITOL, D-
  • D-Mannitol, reagent ACS
  • MANNITOL REAGENT (ACS)
  • MANNITOL GRANULAR
  • MANNITOL,BIOTECHGRADE
  • MANNITOL,FCC
  • MANNITOL,POWDER,USP
  • Cordycepic acid (6CI, 7CI)
  • D-Mannitol (9CI)
  • Mannitol, D- (8CI)
  • Mannit-P
  • Mannogem 2080
  • Marine Crystal
  • DELTA-MANNITOL
  • mannopyranose
  • Diosmol
  • Manicol
  • Manita
  • Hexanehexol, 1,2,3,4,5,6-: (Mannitol)
  • Cordycepic acid Diosmol Manicol