Hydrocinnamoyl chloride
- Product Name
- Hydrocinnamoyl chloride
- CAS No.
- 645-45-4
- Chemical Name
- Hydrocinnamoyl chloride
- Synonyms
- 3-PHENYLPROPANOYL CHLORIDE;HCC;BENZENEPROPANOYL CHLORIDE;3-PHENYLPROPIONYL CHLORIDE;HLD5;FAM126A;SKL1316;DRCTNNB1A;Hydrocinnamoyl;3-Phenylpropionyl ch
- CBNumber
- CB7731088
- Molecular Formula
- C9H9ClO
- Formula Weight
- 168.62
- MOL File
- 645-45-4.mol
Hydrocinnamoyl chloride Property
- Melting point:
- −7-−5 °C(lit.)
- Boiling point:
- 107 °C11 mm Hg(lit.)
- Density
- 1.135 g/mL at 25 °C(lit.)
- vapor pressure
- 6.893Pa at 25℃
- refractive index
- n20/D 1.5265(lit.)
- Flash point:
- 227 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly)
- form
- Liquid
- color
- deep greenish-yellow
- Water Solubility
- Soluble in water (reacts), and ether.
- Sensitive
- Moisture Sensitive
- BRN
- 742586
- LogP
- 1.73
- CAS DataBase Reference
- 645-45-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenepropanoyl chloride(645-45-4)
- EPA Substance Registry System
- Benzenepropanoyl chloride (645-45-4)
Safety
- Hazard Codes
- C
- Risk Statements
- 20-34-29-14
- Safety Statements
- 26-36/37/39-45-8-30-23
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- RTECS
- MW5652395
- F
- 10-21
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29163900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H331Toxic if inhaled
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 249440
- Product name
- Hydrocinnamoyl chloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $33.3
- Updated
- 2025/07/31
- Product number
- 249440
- Product name
- Hydrocinnamoyl chloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $86.5
- Updated
- 2025/07/31
- Product number
- H0696
- Product name
- 3-Phenylpropionyl Chloride
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $74
- Updated
- 2025/07/31
- Product number
- P336215
- Product name
- 3-Phenylpropionyl Chloride
- Packaging
- 50g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- D945
- Product name
- 3-Phenylpropionyl Chloride
- Packaging
- 25g
- Price
- $117
- Updated
- 2021/12/16
Hydrocinnamoyl chloride Chemical Properties,Usage,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.
Uses
Hydrocinnamoyl chloride has been used in:
- enantioselective synthesis of the antifouling agent, (+)-maculalactone A
- synthesis of hydrocinnamoyl-farnesyl-L-cysteine methyl ester
Uses
Hydrocinnamoyl chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.
General Description
Reduction of hydrocinnamoyl chloride at mercury cathodes in acetonitrile containing tetraalkylammonium perchlorates has been investigated by cyclic voltammetry.
Flammability and Explosibility
Not classified
Synthesis
501-52-0
645-45-4
General procedure for the synthesis of hydrocinnamoyl chloride from hydrogenated cinnamic acid: To a 200 mL flask equipped with a stir bar and an argon inlet septum were added hydrogenated cinnamic acid (5.00 g, 33.3 mmol), N,N-dimethylformamide (DMF, 0.1 mL), and dichloromethane (CH2Cl2, 30 mL). Oxalyl chloride ((COCl)2, 2 M in CH2Cl2, 20.0 mL, 40.0 mmol) was slowly added to the resulting solution over 30 min. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by vacuum concentration to afford 3-phenylpropionyl chloride (74, 5.9 g, yellow oil) in 100% yield. The purity of the product was confirmed to be 99% by high performance liquid chromatography (HPLC) analysis (mobile phase ratio: water:acetonitrile:methanol = 15:10:75) with a retention time of 5.3 min.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 10, p. 2899 - 2903
[2] Patent: WO2013/101911, 2013, A2. Location in patent: Page/Page column 57
[3] Arkivoc, 2018, vol. 2018, # 5, p. 334 - 347
[4] Advanced Synthesis and Catalysis, 2015, vol. 357, # 18, p. 3825 - 3830
[5] Journal of the American Chemical Society, 1980, vol. 102, # 20, p. 6311 - 6314
Hydrocinnamoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Hydrocinnamoyl chloride manufacturers
- Product
- Hydrocinnamoyl chloride 645-45-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 3-Phenylpropionyl Chloride 645-45-4
- Price
- US $550.00/Kg
- Min. Order
- 0.100Kg
- Purity
- 99
- Supply Ability
- 1000 Kg
- Release date
- 2024-10-03
- Product
- Hydrocinnamoyl chloride 645-45-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-24