Bufexamac

ChemicalBook > CAS DataBase List > Bufexamac

Product Name: Bufexamac
CAS No.: 2438-72-4
Chemical Name: Bufexamac
Synonyms: j3;cp1044;feximac;mofenar;parfenac;droxaryl;droxarol;cp1044j3;flogicid;norfemac
CBNumber: CB7768637
Molecular Formula: C12H17NO3
Formula Weight: 223.27
MOL File: 2438-72-4.mol

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Bufexamac Property

Melting point:: 153-155°
Boiling point:: 364.56°C (rough estimate)
Density: 1.1223 (rough estimate)
refractive index: 1.5300 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethyl acetate and in methanol.
pka: 9.24±0.20(Predicted)
color: White to Off-White
Merck: 14,1474
CAS DataBase Reference: 2438-72-4(CAS DataBase Reference)

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Safety

WGK Germany: 2
RTECS: AK8280000
HS Code: 2928.00.2500
Toxicity: LD50 orally in mice, rats: >8, >4 g/kg (Lambelin)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B1156000
Product name: Bufexamac
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: b1156000
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: B0760
Product name: Bufexamac
Purity: analytical standard
Packaging: 10g
Price: $97.1
Updated: 2022/05/15

TCI Chemical

Product number: B4179
Product name: Bufexamac
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 26068
Product name: Bufexamac
Purity: ≥98%
Packaging: 250mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 26068
Product name: Bufexamac
Packaging: 25mg
Price: $32
Updated: 2024/03/01

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Bufexamac Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Parfenac,Lederle,UK,1973

Uses

antiinflammatory, analgesic, antipyretic

Uses

Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids.

Uses

Bufexamac is a non-steroidal topical medication used for treatment of a variety of problems in which the skin is inflamed. These vary widely from insect bites to bums, plant stings and a wide variety of medical conditions induding psoriasis, hemorrhoidal symptoms, eczema and inflammation of the skin following radiotherapy. In this last case, it can be used before radiotherapy to help prevent inflammation of the skin caused by radiation therapy.

Definition

ChEBI: A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties.

Manufacturing Process

(1) 136 g of p-hydroxyacetophenone, 140 g of butyl bromide, 152 g of potassium carbonate, 17 g of potassium iodide and 275 cc of ethanol are mixed and then refluxed for 48 hours. The reaction mixture is cooled, diluted with water, then extracted with ether. The ethereal phase is washed with a 10% sodium hydroxide solution, then with water, followed by drying, ether is evaporated and the product distilled under reduced pressure. 168 g of pbutyloxyacetophenone are obtained with yield of 87% (160°-162°C at 11 mm Hg).
(2) 192 g of p-butyloxyacetophenone, 42 g of sulfur and 130 g of morpholine are mixed and then refluxed for 14 hours. The resulting solution is poured into water and stirred until crystallization of the sulfurated complex. The latter is filtered, washed with water and dried, Production: 270 g (88% yield). (3) 200 g of sodium hydroxide are dissolved in 1,500 cc of ethanol and then 293 g of the thus-obtained sulfurated complex are added. The mixture is refluxed overnight, The mixture is distilled to separate the maximum of the alcohol and then diluted with water. The resulting solution is acidified with hydrochloric acid, and extracted with ether. The ethereal phase is washed with water, followed by extraction with a 10% sodium carbonate solution. The carbonated solution is acidified with 10% hydrochloric acid, and the resulting precipitate of p-n-butyloxyphenylacetic acid is filtered and dried. 100 g of this product are obtained (70% yield).
(4) 208 g of p-n-butyloxyphenylacetic acid, 368 g of ethanol and 18 cc of sulfuric acid are refluxed for 5 hours. The mixture is diluted with water, after which it is extracted with ether. The ethereal phase is successively washed with water, then with carbonate, and again with water, following which it is dried and distilled to remove solvent. The ester is then distilled at a reduced pressure. 200 g of ethyl p-butyloxyphenylecetate are thus obtained with yield of 61% (186°C at 8 mm Hg).
(5) 7 g of hydroxylamine hydrochloride are dissolved in 100 cc of methanol. A solution of 5 g of sodium in 150 cc of methanol is added and the salt precipitate is separated by filtration. 22 g of ethyl p-n-butyloxyphenylacetate are added to the filtrate and the mixture is refluxed for 1 hour. The mixture is cooled and acidified with 20% hydrochloric acid. 14.7 g of p-nbutyloxyphenylacetohydroxamic acid are thus obtained with yield of 71% (melting point: 153°-155°C).

brand name

Anderm (Wyeth-Ayerst); Paraderm (Wyeth-Ayerst); Parfenac (Wyeth-Ayerst);Bufemac;Bufexamac-ratiopharm (r) creme;Bufexine ratiopharm(r) f-sable;Calmaderm;Droxan;Droxaryl zalf 50 mg;Duradermal;Flogocid gel n.n;Flogocid sable;Malipuran;Parafenac (r) milch;Parafenac 5% creme;Parafenac basishad;Parafenac sable;Parafenal;Parfenal creme derm;Viafen u est.crema 40 g.

Therapeutic Function

Antiinflammatory, Analgesic, Antipyretic

World Health Organization (WHO)

Bufexamac, an analgesic and anti-inflammatory agent, was introduced in 1974 for the topical treatment of a wide range of dermatoses. The drug is widely marketed and the World Health Organization is not aware of restrictive action having been taken elsewhere.

Contact allergens

Bufexamac is an arylacetic nonsteroidal anti-inflammatory drug. It induces allergic contact dermatitis, eczematous or erythema multiforme like type, and even generalized eruptions like acute generalized exanthematous pustulosis.

Bufexamac Preparation Products And Raw materials

Raw materials

4-Hydroxyphenylacetic acid

Preparation Products

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Bufexamac Suppliers

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View Lastest Price from Bufexamac manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Bufexamac 2438-72-4
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-29

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Bufexamac 2438-72-4
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%-102
Supply Ability: 1000KG
Release date: 2021-06-28

Baoji Guokang Bio-Technology Co., Ltd.

Product: Bufexamac 2438-72-4
Price: US $396.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 1T
Release date: 2021-06-04

2438-72-4, BufexamacRelated Search:

Acetamide Methylparaben Citric acid Styrene Butadiene Rubber Phenoxyacetyl chloride Acetohydroxamic acid Ethyl acetohydroxamate 2-Hydroxyphenylacetic acid 3-Hydroxybenzoic acid Vanadyl acetylacetonate 4-Hydroxybenzoic acid 4-Hydroxybenzaldehyde 4-Hydroxy-D-(-)-2-phenylglycine N-Acetylsulfanilyl chloride 2,3-Butanedione monoxime 2-Phenylacetamide 2-HYDROXYACETAMIDE Ascoric Acid

2-(p-butoxyphenyl)-acetohydroxamicaci

4-butoxy-n-hydroxy-benzeneacetamid

4-butoxy-n-hydroxybenzeneacetamide

4-butoxyphenylacetohydroxamicacid

acidep-butoxyphenylacethydroxamique

bufexamicacid

cp1044

cp1044j3

droxarol

droxaryl

parfenac

p-butoxyphenylacetohydroxamicacid

AURORA KA-853

BUFEXAMAC

2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE

LABOTEST-BB LT00134645

2-(p-butoxyphenyl)acetohydroxamic acid

2-(4-butoxyphenyl)acetohydroxamic acid

4-Butoxyphenylacethydroxamic acid

p-Butoxyphenylacethydroxamic acid

2-(p-Butoxyphenyl)acetohydoroximic acid

2-(4-butoxyphenyl)ethanehydroxamic acid

2-(4-butoxyphenyl)-N-hydroxy-ethanamide

Bufexamac, >=98%

Bufexamac, 98%, a COX inhibitor

feximac

flogicid

flogocidnplastigel

malipuran

mofenar

norfemac

tantalum(2+)

Bufexamac CRS

Bufexamac &gt

Benzeneacetamide, 4-butoxy-N-hydroxy-

Bufexamac USP/EP/BP

Bufexamac (Bufexamic acid)

Bufexamac, ≥ 98.0%

2438-72-4

C12H17NO3

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