3-Fluoro-4-methylbenzoic acid

Product Name: 3-Fluoro-4-methylbenzoic acid
CAS No.: 350-28-7
Chemical Name: 3-Fluoro-4-methylbenzoic acid
Synonyms: RARECHEM AL BO 0761;TIMTEC-BB SBB004034;3-FLUORO-P-TOLUIC ACID;3-FLUORO-4-METHYLBENZOIC ACID;3-FFLUORO-4-METHYLBENZOIC ACID;3-Fluoro-4-methylbenzoicacid97%;3-Fluoro-4-methylbenzoicAcid>Benzoic acid, 3-fluoro-4-methyl-;3-Fluoro-4-methylbenzoic acid 97%;3-Fluoro-4-Methylbenzoic acid, 97% 2.5GR
CBNumber: CB7776151
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 350-28-7.mol

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3-Fluoro-4-methylbenzoic acid Property

Melting point:: 169-171 °C (lit.)
Boiling point:: 203.5°C (rough estimate)
Density: 1.1850 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 4.03±0.10(Predicted)
color: White to Light yellow
BRN: 2574141
InChI: 1S/C8H7FO2/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,1H3,(H,10,11)
InChIKey: XUQCONCMPCVUDM-UHFFFAOYSA-N
SMILES: Cc1ccc(cc1F)C(O)=O
CAS DataBase Reference: 350-28-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25-22-36
WGK Germany: 3
TSCA: TSCA listed
HazardClass: IRRITANT
HS Code: 29163990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F10607
Product name: 3-Fluoro-4-methylbenzoic acid
Purity: 95%
Packaging: 10g
Price: $150
Updated: 2023/01/07

TCI Chemical

Product number: F0552
Product name: 3-Fluoro-4-methylbenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: F0552
Product name: 3-Fluoro-4-methylbenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $228
Updated: 2025/07/31

TRC

Product number: F596420
Product name: 3-Fluoro-4-toluicAcid
Packaging: 25g
Price: $250
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK583662
Product name: 3-Fluoro-4-methylbenzoic acid
Purity: 97%
Packaging: 5g
Price: $102
Updated: 2021/12/16

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3-Fluoro-4-methylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

3-Fluoro-4-toluic Acid was used in the synthesis of cyclooxygenase selective and orally active antiinflammatory agents. It was also used to prepare benzamide derivatives as Bcr-Abl kinase inhibitors.

Synthesis

In a Schlenk (50 mL) reaction flask with a carbon dioxide balloon attached at the stub, Cu(OAc)2.H2O (0.0125 mmol), 1,2-bis(diphenylphosphino)benzene (0.018 mmol), and 1,4-dioxane (2.0 mL) were added with stirring, and then the flask was placed at 60 ??C oil bath for 25 min under carbon dioxide atmosphere, followed by the sequential addition of toluene (8 mL), 3-fluoro-4-methylbromobenzene (1.0 mmol), Pd(OAc)2 (0.03 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyloxanthene (0.06 mmol), Et3N (2.5 mmol, 2.5 equiva. ), then carbon dioxide was removed and the reaction was carried out at 100 ??C until the raw material bromobenzene disappeared, cooled to room temperature and sodium hydroxide solution (1M, 10.0 mL) was added, stirred for 10 min and filtered, the solids were washed with water three times, the filtrate was extracted with ethyl acetate (2 ?? 10 mL) leaving an aqueous layer, the aqueous layer was adjusted to pH 1-2 with hydrochloric acid solution (1M), ethyl acetate (3 ?? 15 mL ) was extracted with ethyl acetate (3??15 mL), dried with anhydrous sodium sulfate, and the solvent was removed to obtain 3-fluoro-4-methylbenzoic acid in 84% yield.

3-Fluoro-4-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-methylbenzoic acid Suppliers

Americas 1 Belgium 1 China 245 Europe 3 France 1 Germany 7 India 14 Italy 1 Japan 3 Switzerland 3 Ukraine 3 United Kingdom 20 United States 44 Global 346

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View Lastest Price from 3-Fluoro-4-methylbenzoic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Fluoro-4-methylbenzoic acid 350-28-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Speranza Chemical Co., Ltd.

Product: 3-Fluoro-4-methylbenzoic acid 350-28-7
Price: US $200.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100MT/year
Release date: 2020-05-06

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Fluoro-4-methylbenzoic acid 350-28-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-05-30

350-28-7, 3-Fluoro-4-methylbenzoic acidRelated Search:

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3-FLUORO-P-TOLUIC ACID

3-FLUORO-4-METHYLBENZOIC ACID

RARECHEM AL BO 0761

3-Fluoro-4-methylbenzoic acid 97%

3-FFLUORO-4-METHYLBENZOIC ACID

3-Fluoro-4-methylbenzoicacid97%

TIMTEC-BB SBB004034

3-Fluoro-4-Methylbenzoic acid, 97% 2.5GR

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3-Fluoro-4-methylbenzoicAcid&gt

Benzoic acid, 3-fluoro-4-methyl-

350-28-7

ARYL ACID

Organic Building Blocks

C8

Carbonyl Compounds

Carboxylic Acids

Building Blocks

Fluorine series

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid

API intermediates

C8

Carbonyl Compounds

Carboxylic Acids

Fluorin-contained Benzoic acid series