ChemicalBook > CAS DataBase List > 5-Bromothiophene-2-carbaldehyde

5-Bromothiophene-2-carbaldehyde

Product Name
5-Bromothiophene-2-carbaldehyde
CAS No.
4701-17-1
Chemical Name
5-Bromothiophene-2-carbaldehyde
Synonyms
5-BROMO-THIOPHENE-2-CARBALDEHYDE;5-BROMOTHIOPHENE-2-CARBOXALDEHYDE;5-BROMO-2-THIOPHENECARBOXALDEHYDE;EA356;AKOS BBS-00003268;TIMTEC-BB SBB000294;5-bromothenaldehyde;5-Bromothiophene-2-c;LABOTEST-BB LT00112291;5-BROMO-2-FORMYLTHIOPHENE
CBNumber
CB7780945
Molecular Formula
C5H3BrOS
Formula Weight
191.05
MOL File
4701-17-1.mol
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5-Bromothiophene-2-carbaldehyde Property

Melting point:
55°C
Boiling point:
105-107 °C11 mm Hg(lit.)
Density 
1.607 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.637(lit.)
Flash point:
210 °F
storage temp. 
2-8°C
solubility 
Soluble in chloroform and methanol.
form 
Liquid After Melting
color 
Clear yellow to brown
Sensitive 
Air Sensitive
BRN 
108404
InChIKey
GFBVUFQNHLUCPX-UHFFFAOYSA-N
LogP
2.566 (est)
CAS DataBase Reference
4701-17-1(CAS DataBase Reference)
NIST Chemistry Reference
5-Bromo-2-thiophenecarboxaldehyde(4701-17-1)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-20/21/22
Safety Statements 
36/37/39-26-22-36
WGK Germany 
3
Hazard Note 
Irritant/Air Sensitive
TSCA 
N
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
152625
Product name
5-Bromo-2-thiophenecarboxaldehyde
Purity
95%
Packaging
25g
Price
$201
Updated
2025/07/31
Sigma-Aldrich
Product number
152625
Product name
5-Bromo-2-thiophenecarboxaldehyde
Purity
95%
Packaging
100g
Price
$540.4
Updated
2025/07/31
TCI Chemical
Product number
B1135
Product name
5-Bromothiophene-2-carboxaldehyde
Purity
>97.0%(GC)
Packaging
5g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
B1135
Product name
5-Bromothiophene-2-carboxaldehyde
Purity
>97.0%(GC)
Packaging
25g
Price
$133
Updated
2025/07/31
TRC
Product number
B688130
Product name
5-Bromo-2-thiophenecarboxaldehyde
Packaging
10g
Price
$50
Updated
2021/12/16
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5-Bromothiophene-2-carbaldehyde Chemical Properties,Usage,Production

Chemical Properties

clear yellow to brown liquid after melting

Uses

5-Bromo-2-thiophenecarboxaldehyde was used to prepare 5-[18F]fluoro-2-2-thiophene carboxaldehyde. Also is used in biological studies as anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1422, 1950 DOI: 10.1021/ja01159a527

Synthesis

98-03-3

4701-17-1

2.1.1 Synthesis of 5-bromo-2-thiophenecarboxaldehyde Under nitrogen protection, 2-thiophenecarboxaldehyde (6.0 g, 53.5 mmol) was dissolved in anhydrous chloroform (125 mL). Subsequently, N-bromosuccinimide (10.4 g, 58.9 mmol) was slowly added and the reaction mixture was stirred for 12 h at room temperature. After completion of the reaction, the mixture was extracted with chloroform (3 × 50 mL), and the organic phases were combined and washed with deionized water (2 × 50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using chloroform as eluent to afford 5-bromo-2-thiophenecarboxaldehyde as a colorless oil (10.0 g, 98% yield). 1H NMR (400 MHz, CDCl3): δ 7.20 (d, 1H, J = 4.0 Hz), 7.53 (d, 1H, J = 8.0 Hz), 9.79 (s, 1H).

References

[1] Physica B: Condensed Matter, 2017, vol. 519, p. 53 - 58
[2] Tetrahedron, 2007, vol. 63, # 37, p. 9188 - 9194
[3] Tetrahedron Letters, 2005, vol. 46, # 12, p. 1989 - 1992
[4] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 134; 135
[5] Journal of the Chemical Society, 1958, p. 1721

5-Bromothiophene-2-carbaldehyde Preparation Products And Raw materials

Raw materials

Triphosgene N,N-Dimethylformamide 2-Bromothiophene Phosphorus oxybromide Carbon tetrachloride Chlorobenzene N-Methylformanilide

Preparation Products

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View Lastest Price from 5-Bromothiophene-2-carbaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-Bromothiophene-2-carbaldehyde 4701-17-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Bromothiophene-2-carbaldehyde 4701-17-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
5-Bromothiophene-2-carbaldehyde 4701-17-1
Price
US $1.00/KG
Min. Order
1G
Purity
99%
Supply Ability
100KG
Release date
2018-08-12

4701-17-1, 5-Bromothiophene-2-carbaldehydeRelated Search:

Cephalothin sodium 2-Thiophenecarboxaldehyde Thifensulfuron methyl Tetrahydrothiophene 5-Bromothiazole Ethyl 5-bromothiophene-2-carboxylate 5-Bromothiophenesulfonyl chloride 5-Bromothiophene-2-sulfonamide METHYL4,5-DIBROMOTHIOPHENE-2-CARBOXYLATE 2-Thiophenecarboxylic acid, 4-amino-5-bromo- 2-Acetyl-5-bromothiophene 2-BROMO-1-(5-BROMOTHIOPHEN-2-YL)ETHANONE 4,5-DIBROMOTHIOPHENE-2-CARBOXALDEHYDE 5-Bromothiophene-2-carbohydrazide 5-Bromo-2-thiophenecarboxylic acid 4,5-DIBROMOTHIOPHENE-2-CARBOXYLIC ACID METHYL 4,5-DIBROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Bromine

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