ChemicalBook > CAS DataBase List > 4-methylquinoline

4-methylquinoline

Product Name
4-methylquinoline
CAS No.
491-35-0
Chemical Name
4-methylquinoline
Synonyms
4-METHYLQUINOLINE;4-Lepidine;4-METHYLCHINOLINE;Lepidin;epidine;LEPIDINE;Lepidine>Lepidine,98%;Lepidine ,99%;4-Methylchinol
CBNumber
CB8121295
Molecular Formula
C10H9N
Formula Weight
143.19
MOL File
491-35-0.mol
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4-methylquinoline Property

Melting point:
9-10 °C(lit.)
Boiling point:
261-263 °C(lit.)
Density 
1.083 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.620(lit.)
Flash point:
>230 °F
storage temp. 
Refrigerator
solubility 
Slightly soluble in water, miscible with alcohol and oils.
pka
5.67(at 20℃)
form 
Liquid
color 
Pale Orange
Odor
at 100.00 %. burnt oily herbal floral sweet
Odor Type
burnt
Water Solubility 
Slightly soluble
Sensitive 
Light Sensitive
Merck 
14,5441
BRN 
110926
InChIKey
MUDSDYNRBDKLGK-UHFFFAOYSA-N
LogP
2.610
CAS DataBase Reference
491-35-0(CAS DataBase Reference)
NIST Chemistry Reference
Quinoline, 4-methyl-(491-35-0)
EPA Substance Registry System
Quinoline, 4-methyl- (491-35-0)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-68-40
Safety Statements 
26-36-45-36/37/39-22
WGK Germany 
3
RTECS 
OH0316000
F 
8-10
TSCA 
Yes
HS Code 
29334900
Hazardous Substances Data
491-35-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
158283
Product name
Lepidine
Purity
99%
Packaging
25g
Price
$99.3
Updated
2024/03/01
Sigma-Aldrich
Product number
158283
Product name
Lepidine
Purity
99%
Packaging
100g
Price
$188
Updated
2024/03/01
TCI Chemical
Product number
L0024
Product name
Lepidine
Purity
>97.0%(GC)(T)
Packaging
25mL
Price
$59
Updated
2024/03/01
TCI Chemical
Product number
L0024
Product name
Lepidine
Purity
>97.0%(GC)(T)
Packaging
100mL
Price
$165
Updated
2024/03/01
Alfa Aesar
Product number
A14040
Product name
Lepidine, 97%
Packaging
10g
Price
$45.65
Updated
2024/03/01
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4-methylquinoline Chemical Properties,Usage,Production

Description

Refer to 6-METHYLQUINOLINE.

Chemical Properties

clear slightly yellow to brown liquid

Physical properties

4-Methylquinoline is a colorless liquid with a weak quinoline-like odor. It is slightly soluble in water, miscible with many organic solvents, and volatile in steam.

Uses

4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging.

Uses

4-methylquinoline is used mainly in flavor compositions for imitation Honey, Nut, Butter, Caramel, etc. and in certain fruit complexes. The concentration used is normally about 0.2 to 2 ppm in the finished product.

Production Methods

4-Methylquinoline can be recovered from the highest-boiling fraction of the coal-tar quinoline bases via its o-cresol addition compound. It can be synthesized by condensation of aniline and methyl vinyl ketone.

Definition

ChEBI: A methylquinoline carrying a methyl substituent at position 4.

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 5291, 1987 DOI: 10.1016/S0040-4039(00)96710-8

General Description

Synthesis of lepidine from 4-anilinobutan-2-one in ethanol in the presence of HCl or FeCl3 has been reported. Nitration of lepidine has been reported.

Purification Methods

Reflux lepidine with BaO, then fractionally distil it. Further purify it via its recrystallised dichromate salt (m 138o) (from H2O). [Cumper et al. J Chem Soc 1176 1962.] [Beilstein 20 III/IV 3477, 20/7 V 389.]

4-methylquinoline Preparation Products And Raw materials

Raw materials

Xylene Acetoacetanilide ZINC Ammonium hydroxide Ethanol Zinc chloride Phosphorus oxychloride Phosphorus pentachloride Iron chloride hexahydrate Iodine Aniline Ethyl acetate Acetic acid Methyl vinyl ketone Phosphorus Sulfuric acid

Preparation Products

QUINOLINE-4-CARBOXYLIC ACID 4-Quinolinecarboxaldehyde METHYL 8-AMINOQUINOLINE-4-CARBOXYLATE
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4-methylquinoline Suppliers

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View Lastest Price from 4-methylquinoline manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Lepidine 491-35-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-13
Hebei Mojin Biotechnology Co., Ltd
Product
4-methylquinoline 491-35-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-25
Career Henan Chemical Co
Product
Lepidine 491-35-0
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

491-35-0, 4-methylquinolineRelated Search:

8-Hydroxyquinoline quinolinium hydrogen sulphate Ethoxyquin 8-Methylquinoline Quinclorac Isoquinoline 2-HYDROXY-4-METHYLQUINOLINE 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Quinhydrone CINCHOPHEN 1,1'-DIETHYL-4,4'-CARBOCYANINE IODIDE QUINOLINE-4-CARBOXYLIC ACID Lepidine, 2-chloro- Bathophenanthroline 2,4-DIMETHYLQUINOLINE BATHOPHENANTHROLINEDISULFONIC ACID DISODIUM SALT TRIHYDRATE 3,4,7,8-Tetramethyl-1,10-phenanthroline 4,7-Dimethyl-1,10-phenanthroline

  • 4-METHYLQUINUOLINE
  • 4-METHYLQUINOLINE 99+%
  • LEPIDINE, 99% (4-METHYLQUINOLINE)
  • Lepidine(4-Methylquinoline)99%
  • Lepidine,98%
  • 4-Methylquinoline, Lepidine
  • Lepidine ,99%
  • 4-Methylquinoline,4-Methylquinoline, Lepidine
  • Lepidine, 99% 100GR
  • Lepidine, 99% 25GR
  • 4-Methylchinolin
  • 4-Methylchinol
  • 4-Methylquinoline≥ 99% (GC)
  • 4-methyl-quinolin
  • Cincholepidine
  • gamma-Methylquinoline
  • Lepidin
  • -Methylquinoline
  • Quinoline,4-methyl-
  • 4-METHYLQUINOLINE
  • 4-METHYLCHINOLINE
  • 4-Lepidine
  • LEPIDINE
  • Lepidine&gt
  • epidine
  • Lepidine ISO 9001：2015 REACH
  • Lepidine, ≥ 97.0%
  • Atazanavir Impurity 45
  • 3-(4'-Methylbenzylidene)camphor
  • 4-Methylquinoline in isooctane
  • 491-35-0
  • C10H9N1
  • Alkylquinolines
  • Quinolines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Alkylquinolines
  • Quinolines
  • Quinoline Derivertives
  • Quinoline series