ChemicalBook > CAS DataBase List > Hydroxylamine hydrochloride

Hydroxylamine hydrochloride

Product Name
Hydroxylamine hydrochloride
CAS No.
5470-11-1
Chemical Name
Hydroxylamine hydrochloride
Synonyms
HYDROXYLAMINE HCL;HYDROXYLAMMONIUM CHLORIDE;hydroxyaminehydrochloride;HYDROXYAMMONIUM CHLORIDE;HYDROXYLAMINE HYDROCHLORID;OXAMMONIUM HCL;Hydroxylamine hydroc;HA HCL;HOHCL;Oxammionium
CBNumber
CB8128885
Molecular Formula
NH2OH·HCl
Formula Weight
69.49
MOL File
5470-11-1.mol
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Hydroxylamine hydrochloride Property

Melting point:
155-157 °C (dec.)(lit.)
Density 
1.67 g/mL at 25 °C(lit.)
vapor pressure 
0.054 Pa (50 °C)
storage temp. 
Store at +15°C to +25°C.
solubility 
470g/l
form 
Liquid
color 
White to off-white
PH
2.5-3.5 (25℃, 50mg/mL in H2O)
Water Solubility 
560 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,4828
BRN 
3539763
Stability:
Substances to be avoided include strong oxidizing agents. Heating above 115 C may cause explosion; do not store above 65C. Moisture and air sensitive.
InChIKey
WTDHULULXKLSOZ-UHFFFAOYSA-N
LogP
-0.810 (est)
CAS DataBase Reference
5470-11-1(CAS DataBase Reference)
EPA Substance Registry System
Hydroxylamine hydrochloride (5470-11-1)
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Safety

Hazard Codes 
Xn,N,E
Risk Statements 
22-36/38-43-48/22-50-40-21/22-2
Safety Statements 
22-24-37-61-36/37
RIDADR 
UN 2923 8/PG 2
WGK Germany 
3
RTECS 
NC3675000
F 
21
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
28251000
Toxicity
LD50 orally in mice: 408 mg/kg (Riemann)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H290May be corrosive to metals

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
159417
Product name
Hydroxylamine hydrochloride
Purity
ReagentPlus , 99%
Packaging
1kg
Price
$175
Updated
2024/03/01
Sigma-Aldrich
Product number
159417
Product name
Hydroxylamine hydrochloride
Purity
ReagentPlus , 99%
Packaging
3kg
Price
$362
Updated
2024/03/01
Sigma-Aldrich
Product number
1.04616
Product name
Hydroxylammonium chloride
Purity
GR for analysis ACS,ISO,Reag. Ph Eur
Packaging
250g
Price
$122
Updated
2024/03/01
Sigma-Aldrich
Product number
1.04619
Product name
Hydroxylammonium chloride
Purity
for analysis (≤ 0.000001% Hg) ACS,ISO
Packaging
250g
Price
$441
Updated
2024/03/01
Sigma-Aldrich
Product number
1.04616
Product name
Hydroxylammonium chloride
Purity
GR for analysis ACS,ISO,Reag. Ph Eur
Packaging
1kg
Price
$396
Updated
2024/03/01
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Hydroxylamine hydrochloride Chemical Properties,Usage,Production

Description

Hydroxylamine hydrochloride is a reducing agent that is routinely used for the deacetylation of SATA to form free sulfhydryls (Figure 1), for cleavage of protein cross‐linkers that contain carbonyl groups (i.e. EGS) and for mutagenesis of plasmid DNA.

Hydroxylamine converts aldehydes and ketones (carbonyls) to their oxime derivative in weak bases, therefore cross‐linkers and other compounds with carbonyl groups are cleavable with Hydroxylamine hydrochloride.
SATA and SATP are modification reagents that add a sulfhydryl group to primary amines on biomolecules. The initial modification results in the addition of an acetyl‐protected sulfur enabling storage of the biomolecule. To generate a free sulfhydryl the biomolecule is treated with hydroxylamine to remove the protecting acetyl group (see figure).
EGS and sulfo‐EGS are homobifunctional, succinimidyl ester, amine reactive crosslinkers that are resistant to cleavage by denaturants used in SDS‐PAGE conditions, but may be cleaved with hydroxylamine.

Chemical Properties

Hydroxylamine Hydrochloride(NH2OH.HCl) is an inorganic compound that is the hydrochloric acid salt of hydroxylamine. It is highly hygroscopic and decomposes when exposed to dampness above 151℃. This compound is primarily used as a reducing agent and imaging agent and is instrumental in the preparation of oximes in organic synthesis. It can convert aldehydes and ketones to oximes and acid chlorides to hydroxamic acids. However, This product is highly toxic and irritating to the skin.

Physical properties

It is a colorless monoclinic crystal that is hygroscopic and decomposes slowly in moist air. It has a density of 1.67 g/cm3 at a temperature of 17°C and melts at 151°C with decomposition. It is highly soluble in water, with a solubility of 84g/100g at 20°C, and is also soluble in lower alcohols and glycols. A 0.1 molar solution of this substance has a pH of 3.4.

Characteristics

Features of Hydroxylamine hydrochloride:
Quench amine-labeling or crosslinking reactions (e.g., with NHS esters)
Expose protected sulfhydryl groups on SATA-modified molecules
Cleave carbonyl-containing crosslinkers such as EGS and Sulfo-EGS

Uses

Hydroxylamine hydrochloride is a monomoamine oxidase inhibitor. It is used to prepare oximes and hydroxmic acids in organic synthesis. It acts as a copolymerization inhibitor. It can be used to remove bromine and polybromide from a solution during extraction of lignin from lignocellulosic biomass. It is key starting material for the preparation of pharmaceuticals and agrochemicals. It plays a vital role in rubber and plastic industries as an antioxidant, a vulcanization accelerator and a radical scavenger. It is also used as a color stabilizer and emulsion additive in color films.

Preparation

Hydroxylamine hydrochloride is prepared by electrolytic reduction of ammonium chloride. Or by the action of nitromethane with hydrochloric acid and water to obtain hydroxylamine hydrochloride.

Definition

ChEBI: Hydroxylamine hydrochloride is an organic molecular entity. It is a colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.

Biotechnological Applications

Hydroxylamine hydrochloride is a strong reducing agent that is useful in biochemical crosslinking applications, including the deacetylation of SATA and chemical cleavage of EGS and Sulfo-EGS. Hydroxylamine converts carbonyl compounds (aldehydes and ketones) to their oxime derivatives in the presence of a weak base. Therefore, crosslinkers and other compounds that contain a carbonyl within their structure are cleavable with hydroxylamine?HCl.
MAN0011201_HydroxylamineHCl_UG.pdf

General Description

Hydroxylamine hydrochloride appears as colorless or off-white crystalline solid. pH (0.1 molar aqueous solution) 3.4. pH (0.2 molar aqueous solution) 3.2. (NTP, 1992)

Air & Water Reactions

Hygroscopic. Sensitive to prolonged exposure to air. Water soluble. Reacts slowly with water.

Reactivity Profile

A powerful reducing agent. Reacts with bases and oxidizing agents.

Hazard

Toxic by ingestion, strong irritant to tissue.

Fire Hazard

Flash point data for Hydroxylamine hydrochloride are not available; however, Hydroxylamine hydrochloride is probably combustible.

Contact allergens

Hydroxylamine and its salts are used in various branches of industry, as reducing agents in color film developers or as reagents in laboratories.

Biochem/physiol Actions

MAO inhibitor; inhibits platelet aggregation.

Purification Methods

Crystallise the salt from aqueous75% ethanol or boiling methanol, and dry it under vacuum over CaSO4 or P2O5. It has also been dissolved in a minimum of water and saturated with HCl; after three such crystallisations, it is dried under a vacuum over CaCl2 and NaOH. Its solubility at 20o is 85% in H2O, 6% in EtOH and 12% in MeOH. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1941.]

Hydroxylamine hydrochloride Preparation Products And Raw materials

Raw materials

Nitromethane Water Sodium nitrite Acetone oxime Sodium metabisulfite Dimethyl sulfate

Preparation Products

2-CHLOROBENZALOXIME Pyrazole-1,3-dimethyl-5-phenoxy-4-carboxaldehyde oxime Methyl 3-amino-4-methylthiophene-2-carboxylate 4-(METHYLTHIO)BENZYLAMINE 4-AMINO-1,2,5-OXADIAZOLE-3-CARBONITRILE 2-Pyridylamid oxime 5-AMINOISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 5-METHYLISOXAZOLE-3-CARBOXYLATE 5 A-CHLORO-6 B,19-EPOXY-3 B -HYDROXY-5 A-ANDROSTAN-17-ONE 4-Pyridylamidoxime 5-Chloro-3,6-dihydroxy-5-androstan-17-one 3-acetate ETHYL 3-(2,6-DICHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLATE 3,4,5-Trimethoxybenzylamine Epiandrosterone acetate 3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid 2-Butanone oxime 5-METHYL-4-ISOXAZOLESULFONYL CHLORIDE NEMONAPRIDE 5-Methyl-3-phenylisoxazole 2,6-Dicyano-4-Nitroaniline DIPHENYLGLYOXIME 6-AMINO-2-METHYL-2-HEPTANOL 3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride 6-Bromoisatin 4-Aminotetrahydropyran hydrochloride 5-Methyl-3-phenylisoxazole-4-carbonyl chloride 3-METHYLTHIOPHENE-2-CARBONITRILE (2,6-DIMETHYLPHENOXY)ACETOXIME 3-(2-Chlorophenyl)-5-methylisoxazole-4-carboxylic acid 3-METHYL-5-PHENYLISOXAZOLE Adrafinil 3-PYRIDYLAMIDOXIME Ethyl 5-methyl-3-phenylisoxazole-4-carboxylate BENZAMIDOXIME HYDROCHLORIDE 2,3-DIMETHOXYBENZONITRILE heptanal oxime 17-Ethinylandrost-5-ene-3,17-diol N-Hydroxysulfosuccinimide sodium salt 3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID 2-AMINO-5,6-DICHLOROBENZOIC ACID
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View Lastest Price from Hydroxylamine hydrochloride manufacturers

Dorne Chemical Technology co. LTD
Product
Hydroxylamine hydrochloride 5470-11-1
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
HebeiShuoshengImportandExportco.,Ltd
Product
Hydroxylamine hydrochloride 5470-11-1
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-02
Jinan Finer Chemical Co., Ltd
Product
Hydroxylamine hydrochloride 5470-11-1
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10000mt/year
Release date
2020-09-07

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