PERTUSSIS TOXIN

Product Name: PERTUSSIS TOXIN
CAS No.: 70323-44-3
Chemical Name: PERTUSSIS TOXIN
Synonyms: PTX;iap;HOLOTOXIN;IAG2;ALPI;MAGT1;PSEC0084;pertussigen;UNQ628/PRO1244;pertussistoxins
CBNumber: CB8145592
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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PERTUSSIS TOXIN Property

storage temp.: 2-8°C
solubility: Water: soluble
form: lyophilized powder

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Safety

Hazard Codes: T,B,Xi
Risk Statements: 23/24/25-36/37/38
Safety Statements: 36/37/39-45-26
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: XW5883750
F: 10
HazardClass: 6.1(a)
PackingGroup: I

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7208
Product name: Pertussis toxin from Bordetella pertussis
Purity: lyophilized powder
Packaging: 50μg
Price: $592
Updated: 2024/03/01

Sigma-Aldrich

Product number: P2980
Product name: Pertussis toxin from Bordetella pertussis
Purity: buffered aqueous glycerol solution
Packaging: 50μg
Price: $628
Updated: 2024/03/01

Sigma-Aldrich

Product number: P2980
Product name: Pertussis toxin from Bordetella pertussis
Purity: buffered aqueous glycerol solution
Packaging: 0.2mg
Price: $2100
Updated: 2024/03/01

Sigma-Aldrich

Product number: 516561
Product name: Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem
Purity: Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.
Packaging: 50μG
Price: $489
Updated: 2024/03/01

Sigma-Aldrich

Product number: 516560
Product name: Pertussis Toxin, Bordetella pertussis - CAS 70323-44-3 - Calbiochem
Purity: This Pertussis toxin, CAS 70323-44-3, catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins Gi, Go, and Gt.
Packaging: 50μG
Price: $489
Updated: 2024/03/01

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PERTUSSIS TOXIN Chemical Properties,Usage,Production

Uses

The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.

General Description

Product is not activated. If activation is required, see Kaslow, et al., for suggested conditions.

Biochem/physiol Actions

Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.

storage

Store at +4°C

Purification Methods

Purify the toxin by stepwise elution from 3 columns comprising Blue Sepharose, Phenyl Sepharose and hydroxylapatite, and the purity is checked by SDS-PAGE. [Svoboda et al. Anal Biochem 159 402 1986, Biochemistry 21 5516 1982, Biochem J 83 295 1978.]

PERTUSSIS TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PERTUSSIS TOXIN Suppliers

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70323-44-3, PERTUSSIS TOXINRelated Search:

DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Cupric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE Aluminum acetylacetonate N-BUTYLISOCYANIDE SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ethyl isocyanoacetate PHENYLSELENOL Tris(2,4-pentanedionato)chroMiuM(III) METHYL ISOCYANOACETATE COBALT(II) ACETYLACETONATE

histamine-sensitizingfactor

iap

Protein-based AB5-type exotoxin with five dissimilar subunits: S-1 (M.W. 28 kDa), S-2 (M.W. 23 kDa), S-3 (M.W. 22 kDa), S-4 (M.W. 11.7 kDa) and S-5 (M.W. 9.3 kDa), in a molar ratio of 1:1:1:2:1

Pertussis toxin from Bordetella pertussis,Histamine-sensitizing factor, IAP, Islet Activating Protein, Pertussigen

ANTI-ALKALINE PHOSPHATASE (ALPI) (CENTER antibody produced in rabbit

ANTI-MAGT1 (N-TERM) antibody produced in rabbit

IAG2

Implantation-associated protein

Magnesium transporter protein 1

MAGT1

PSEC0084

UNQ628/PRO1244

ALPI

lymphocytosis-promotingfactor

pertussigen

pertussistoxins

toxins,pertussis

PTX

PERTUSSIS TOXIN

PERTUSSIS TOXIN, BORDETELLA PERTUSSIS

BORDETELLA PERTUSSIS TOXIN

ISLET ACTIVATING PROTEIN

HOLOTOXIN

Pertussis toxin from Bordetella pertussis

pertussis toxin from bordetella per-tussis

POLYETHYLENE GLYCOL AV. MOL. WT. 200

PERTUSSIS TOXIN FROM BORDETELLA PER-TUSS IS, 50 UG TOXIN

Histamine-sensitizing factor, IAP, Islet Activating Protein, Pertussigen

Bordetella pertussis toxin DISCONTINUED

70323-44-3

C87H162N14O16S2

Cell Biology

Cell Signaling and Neuroscience

BioChemical

G Proteins and Cyclic Nucleotides

G Protein Function

Reagents

G-Protein