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PERTUSSIS TOXIN

Product Name
PERTUSSIS TOXIN
CAS No.
70323-44-3
Chemical Name
PERTUSSIS TOXIN
Synonyms
PTX;iap;HOLOTOXIN;IAG2;ALPI;MAGT1;PSEC0084;pertussigen;UNQ628/PRO1244;pertussistoxins
CBNumber
CB8145592
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
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PERTUSSIS TOXIN Property

storage temp. 
2-8°C
solubility 
Water: soluble
form 
lyophilized powder
color 
White to off-white
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Safety

Hazard Codes 
T,B,Xi
Risk Statements 
23/24/25-36/37/38
Safety Statements 
36/37/39-45-26
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
XW5883750
F 
10
HazardClass 
6.1(a)
PackingGroup 
I
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7208
Product name
Pertussis toxin from Bordetella pertussis
Purity
lyophilized powder
Packaging
50μg
Price
$592
Updated
2024/03/01
Sigma-Aldrich
Product number
P2980
Product name
Pertussis toxin from Bordetella pertussis
Purity
buffered aqueous glycerol solution
Packaging
50μg
Price
$628
Updated
2024/03/01
Sigma-Aldrich
Product number
P2980
Product name
Pertussis toxin from Bordetella pertussis
Purity
buffered aqueous glycerol solution
Packaging
0.2mg
Price
$2100
Updated
2024/03/01
Sigma-Aldrich
Product number
516561
Product name
Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem
Purity
Pertussis Toxin, Bordetella pertussis, Glycerol Solution, CAS 70323-44-3, is a protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.
Packaging
50μG
Price
$489
Updated
2024/03/01
Sigma-Aldrich
Product number
516560
Product name
Pertussis Toxin, Bordetella pertussis - CAS 70323-44-3 - Calbiochem
Purity
This Pertussis toxin, CAS 70323-44-3, catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins Gi, Go, and Gt.
Packaging
50μG
Price
$489
Updated
2024/03/01
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PERTUSSIS TOXIN Chemical Properties,Usage,Production

Uses

The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.

General Description

Product is not activated. If activation is required, see Kaslow, et al., for suggested conditions.

Biochem/physiol Actions

Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.

storage

Store at +4°C

Purification Methods

Purify the toxin by stepwise elution from 3 columns comprising Blue Sepharose, Phenyl Sepharose and hydroxylapatite, and the purity is checked by SDS-PAGE. [Svoboda et al. Anal Biochem 159 402 1986, Biochemistry 21 5516 1982, Biochem J 83 295 1978.]

PERTUSSIS TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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70323-44-3, PERTUSSIS TOXINRelated Search:

DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Cupric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE Aluminum acetylacetonate N-BUTYLISOCYANIDE SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ethyl isocyanoacetate PHENYLSELENOL Tris(2,4-pentanedionato)chroMiuM(III) METHYL ISOCYANOACETATE COBALT(II) ACETYLACETONATE

  • histamine-sensitizingfactor
  • iap
  • Protein-based AB5-type exotoxin with five dissimilar subunits: S-1 (M.W. 28 kDa), S-2 (M.W. 23 kDa), S-3 (M.W. 22 kDa), S-4 (M.W. 11.7 kDa) and S-5 (M.W. 9.3 kDa), in a molar ratio of 1:1:1:2:1
  • Pertussis toxin from Bordetella pertussis,Histamine-sensitizing factor, IAP, Islet Activating Protein, Pertussigen
  • ANTI-ALKALINE PHOSPHATASE (ALPI) (CENTER antibody produced in rabbit
  • ANTI-MAGT1 (N-TERM) antibody produced in rabbit
  • IAG2
  • Implantation-associated protein
  • Magnesium transporter protein 1
  • MAGT1
  • PSEC0084
  • UNQ628/PRO1244
  • ALPI
  • lymphocytosis-promotingfactor
  • pertussigen
  • pertussistoxins
  • toxins,pertussis
  • PTX
  • PERTUSSIS TOXIN
  • PERTUSSIS TOXIN, BORDETELLA PERTUSSIS
  • BORDETELLA PERTUSSIS TOXIN
  • ISLET ACTIVATING PROTEIN
  • HOLOTOXIN
  • Pertussis toxin from Bordetella pertussis
  • pertussis toxin from bordetella per-tussis
  • POLYETHYLENE GLYCOL AV. MOL. WT. 200
  • PERTUSSIS TOXIN FROM BORDETELLA PER-TUSS IS, 50 UG TOXIN
  • Histamine-sensitizing factor, IAP, Islet Activating Protein, Pertussigen
  • Bordetella pertussis toxin DISCONTINUED
  • 70323-44-3
  • C87H162N14O16S2
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • G Proteins and Cyclic Nucleotides
  • G Protein Function
  • Reagents
  • G-Protein