ChemicalBook > CAS DataBase List > 2-Bromo-3-methylthiophene

2-Bromo-3-methylthiophene

Product Name
2-Bromo-3-methylthiophene
CAS No.
14282-76-9
Chemical Name
2-Bromo-3-methylthiophene
Synonyms
2B3MT;178.04;TH1-Br;2-Bromo-3-methylthio;2-bromo-3-methyltiophene;3-Methyl-2-bromothiophene;2-BROMO-3-METHYLTHIOPHENE;Thiophene,2-bromo-3-methyl-;2-Bromo-3-methylthiophene>2-Bromo-3-methylthiophene 97%
CBNumber
CB8147031
Molecular Formula
C5H5BrS
Formula Weight
177.06
MOL File
14282-76-9.mol
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2-Bromo-3-methylthiophene Property

Melting point:
<25 °C
Boiling point:
173-176 °C (lit.)
Density 
1.572 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.572(lit.)
Flash point:
155 °F
storage temp. 
2-8°C
Water Solubility 
Insoluble in water
solubility 
soluble in Chloroform, Ethyl Acetate
form 
liquid
color 
Pale yellow
Specific Gravity
1.580
BRN 
105719
CAS DataBase Reference
14282-76-9(CAS DataBase Reference)
NIST Chemistry Reference
Thiophene, 2-bromo-3-methyl-(14282-76-9)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
25-41-43-36/37/38-20/21/22
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2810
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT-HARMFUL, KEEP COLD
HazardClass 
6.1
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
337021
Product name
2-Bromo-3-methylthiophene
Purity
95%
Packaging
1g
Price
$26.4
Updated
2023/06/20
Sigma-Aldrich
Product number
337021
Product name
2-Bromo-3-methylthiophene
Purity
95%
Packaging
5g
Price
$71.7
Updated
2023/06/20
TCI Chemical
Product number
B1025
Product name
2-Bromo-3-methylthiophene
Purity
>98.0%(GC)
Packaging
5g
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
B1025
Product name
2-Bromo-3-methylthiophene
Purity
>98.0%(GC)
Packaging
25g
Price
$129
Updated
2024/03/01
Alfa Aesar
Product number
L11393
Product name
2-Bromo-3-methylthiophene, 97%
Packaging
5g
Price
$53.65
Updated
2024/03/01
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2-Bromo-3-methylthiophene Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

2-Bromo-3-methylthiophene was used in the preparation of poly(3,3′′′-dimethyl-(2,2′:5′,2′:5′,2′′′)tetrathiophene)). It was also used in the preparation of 2-bromo-3-(bromomethyl)thiophene, lachrymatory compound.

Application

2-Bromo-3-methylthiophene is used as a pharmaceutical intermediate. It is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.

Preparation

2-Bromo-3-methylthiophene synthesis: To a solution of glacial AcOH (100 mL), acetic anhydride (4.0 g, 0.039 mol), and 3-methylthiophene (9.82 g, 0.100 mol) as a stirred mixture was added NBS (19.6 g, 0.11 mol) in one portion with a slight exotherm to 44 oC. After 20 min the reaction mixture was poured onto ice, neutralized with sodium bisulfite and extracted with ether. The ether layer was washed with water and concentrated to give 11.3 g (64%) of 2-bromo-3-methylthiophene as a tan colored liquid in 88% purity by GC area % analysis: 1H NMR (CDCl3) d 7.1 (d, 1H, J=5.7 Hz), 6.7 (d, 1H, J=5.9 Hz), 2.2 (s, 3H).

General Description

2-Bromo-3-methylthiophene is formed (approx. 90%) by bromination of 3-methyl thiophene with N-bromosuccinimide in the absence of benzoyl peroxide.

2-Bromo-3-methylthiophene Preparation Products And Raw materials

Raw materials

Preparation Products

3-METHYLTHIOPHENE-2-BORONIC ACID 2,3,5-Trimethylthiophene
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2-Bromo-3-methylthiophene Suppliers

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View Lastest Price from 2-Bromo-3-methylthiophene manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Bromo-3-methylthiophene 14282-76-9
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-22
Hebei Weibang Biotechnology Co., Ltd
Product
2-Bromo-3-methylthiophene 14282-76-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
2-Bromo-3-methylthiophene 14282-76-9
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-08

14282-76-9, 2-Bromo-3-methylthiopheneRelated Search:

4-Bromomethylbenzoic acid 3-Methylthiophene (Bromomethyl)cyclopropane Bromotrimethylsilane Poly(3-hexylthiophene-2,5-diyl) 2-Bromothiophene Methyl bromide Bromine 2-BROMO-5-CHLORO-3-METHYLBENZO[B]THIOPHENE 2,3,5-TRIBROMO-4-METHYLTHIOPHENE 2,5-DIBROMO-3-DECYLTHIOPHENE 2,5-Dibromo-3-hexylthiophene 2,5-Dibromo-3-octylthiophene 2,5-DIBROMO-3-METHYLTHIOPHENE 2,5-DIBROMO-3-DODECYLTHIOPHENE 2,5-DIBROMO-3-BUTYLTHIOPHENE 2-Bromo-3-bromomethylthiophene 3-bromo-2-methylthiophene

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  • TH1-Br
  • 2-Bromo-3-methylthiophene&gt
  • 2-Bromo-3-methylthiophene ISO 9001：2015 REACH
  • 14282-76-9
  • 14282-75-9
  • C5H5Br
  • Thiophenes
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • ARYL HALIDE
  • Building Blocks
  • Building Blocks
  • C4 to C6
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocycle-oher series
  • Thiophene Series
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • ThiophenesBuilding Blocks
  • Halogenated
  • Organohalides
  • Thiophene
  • Thiophens
  • blocks
  • Bromides
  • Heterocycles
  • Thiophene&Benzothiophene
  • Thiophenes