Description
ChemicalBook > CAS DataBase List > Diflubenzuron

Diflubenzuron

Description
Product Name
Diflubenzuron
CAS No.
35367-38-5
Chemical Name
Diflubenzuron
Synonyms
DIMILIN;Largon;3-(2,6-Difluorobenzoyl)-1-(4-chlorophenyl)urea;th6040;PH60-40;ph-6040;oms1804;DIMILAN;astonex;th60-40
CBNumber
CB8162496
Molecular Formula
C14H9ClF2N2O2
Formula Weight
310.68
MOL File
35367-38-5.mol
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Diflubenzuron Property

Melting point:
230-232°C
Density 
1.4301 (estimate)
vapor pressure 
1.2 x l0-4 mPa (25 °C)
storage temp. 
0-6°C
solubility 
DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
pka
8.78±0.46(Predicted)
form 
Solid
Water Solubility 
0.008 g/100 mL
Merck 
13,3166
BRN 
2162461
CAS DataBase Reference
35367-38-5(CAS DataBase Reference)
NIST Chemistry Reference
Difluron(35367-38-5)
EPA Substance Registry System
Diflubenzuron (35367-38-5)
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Safety

Hazard Codes 
C,N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
3077
WGK Germany 
2
RTECS 
YS6200000
HazardClass 
9
PackingGroup 
III
HS Code 
2924210090
Hazardous Substances Data
35367-38-5(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (formulation with 50% kaolin) (g/kg): 4.64, >10 orally (Mulder, Gijswijt)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H312Harmful in contact with skin

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
77070
Product name
Diflubenzuron
Purity
certified reference material, TraceCERT
Packaging
50mg
Price
$247
Updated
2024/03/01
Sigma-Aldrich
Product number
45446
Product name
Diflubenzuron
Purity
PESTANAL
Packaging
250mg
Price
$81.3
Updated
2024/03/01
Cayman Chemical
Product number
23095
Product name
Diflubenzuron
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23095
Product name
Diflubenzuron
Packaging
100mg
Price
$61
Updated
2024/03/01
TRC
Product number
D445520
Product name
Diflubenzuron
Packaging
10g
Price
$275
Updated
2021/12/16
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Diflubenzuron Chemical Properties,Usage,Production

Description

Diflubenzuron is an insecticide of the benzoylurea class.It is used in forest management and on field crops to selectively control insect pests, particularly forest tent caterpillar moths, boll weevils, gypsy moths, and other types of moths.It is a widely used larvicide in India for control of mosquito larvae by public health authorities. Diflubenzuron is approved by the WHO Pesticide Evaluation Scheme.

Description

Diflubenzuron is a benzoylphenylurea insecticide that inhibits chitin synthesis in insects with an IC50 value of 0.611 nM for 14C-labeled N-acetyl-D-glucosamine incorporation in the cockroach. Specifically, it inhibits chitin synthetase at the egg and larval stages, leading to an inability to exit the egg or exocuticle, respectively. Diflubenzuron is genotoxic and mutagenic in mice at doses of 0.3, 1, and 3 mg/kg. Formulations containing diflubenzuron are used primarily in agricultural applications but are also used to control insects in livestock production.

Description

Diflubenzuron is produced by the reaction of 2,6-difluorobenzamide with 4-chlorophenylisocyanate. Diflubenzuron was first registered as a pesticide in the United States in 1979. Environmental Protection Agency issued a Registration Standard for diflubenzuron in September 1985 (PB86-176500). In 1991, a Data Call-In was made to require additional residue chemistry and ecological effects data. The current Reregistration Eligibility Decision Document was issued in August 1997, reflecting analysis of the new data.

Uses

Diflubenzuron is used for the control of a wide range of leaf-eating insects in forestry, woody ornamentals and fruit. It controls major pests on cotton, soyabean, citrus and tea and it also controls larvae of flies, mosquitoes and locusts. Diflubenzuron is also used as an ectoparasiticide.

Uses

Diflubenzuron is a benzoylurea-based pesticide belonging to the benzamide class. Diflubenzuron is a chitin synthesis inhibitor. Diflubenzuron is used in both agriculture and forest management to selec tively control insect pests, particularly moths and weevils.

Uses

Insecticide.

Uses

An inhibitor of TCDD-induced CYP1a1 expression in HepG2 cells.

Uses

nsystemic insecticide used to control leaf-eating larvae and leaf miners in forestry, woody ornamentals and fruit trees.

Definition

ChEBI: A benzoylurea insecticide that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 4-chlorophenyl group, and a hydrogen attached to the other nitrogen is replaced bgy a 2,6-difluorobenzoyl group.

General Description

Colorless to yellow crystals. Used as a selective insecticide.

Air & Water Reactions

Hydrolyzed in alkaline solution above pH 9.0.

Reactivity Profile

A urea derivative.

Agricultural Uses

Insecticide, Larvicide: Diflubenzuron is used primarily on citrus, cattle feed, cotton, forestry, mushrooms, ornamentals, pastures, soybeans, standing water, sewage systems, and wide-area general outdoor treatment sites. The insecticide behaves as a chitin inhibitor to inhibit the growth of many leaf-eating larvae, mosquito larvae, aquatic midges, rust mite, boll weevil, and house-black-, and stable-flies. Diflubenzuron was first registered in the United States in 1979 for use as an insecticide.

Trade name

ADEPT®; ASTONEX®; DIMILIN®; DIMILIN® FLO; DIMILIN® WG-80; DU-112307®; DUPHAR® PH 60-40; ODC-45®; DIFLURON®; DU 112307®; LARGON®; LARVAKIL®; MICROMITE®; OMS 1804®; PDD 60401®; PH 60- 40®; PHILIPS-DUPHAR® PH 60-40; TH 60-40®; THOMPSON-HAYWARD® 6040; VIGILANTE®

Safety Profile

Moderately toxic by skin contact. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, F-, and NOx.

Environmental Fate

Soil. The half-life in soil is <1 week (Hartley and Kidd, 1987). Di?ubenzuron degrades more rapidly in neutral or basic conditions but more slowly under acidic conditions (pH <6) (Ivie et al., 1980).
Chemical/Physical. Hydrolyzes in water to 4-chlorophenylurea (Verschueren, 1983).

Metabolic pathway

Diflubenzuron was the first active substance commercialised as a benzoylurea insect growth regulator and there is extensive published information on its degradation and metabolism. Detailed studies of the degradation in soils have shown that cleavage of the urea linkage is the major process. This also occurs in plants, insects and mammals but the formation of products in which diflubenzuron is hydroxylated in both rings is also an important metabolic process.

Degradation

Diflubenzuron was shown to be stable to hydrolysis in aqueous solution at acidic pH (DT50> 56 days at pH 4) but was readily hydrolysed at pH 10 (DT50 <3 days). In distilled water the DTa was 7 days (Ivie et al., 1980). The major degradation products isolated were 4-chlorophenylurea (2) and 2,6-difluorobenzoic acid (3). An additional minor product was 2,6- difluorobenzamide (4). The hydrolysis products are shown in Scheme 1. Additional products were formed under extreme conditions (121 °C under pressure).
Aqueous solutions of diflubenzuron are reported to be unstable to light but the solid is stable in sunlight (PM).

Toxicity evaluation

Diflubenzuron is an odorless, white, crystalline solid with a melting point of 230–232 C. It is almost insoluble in water (0.2 mg l1) and poorly soluble in apolar organic solvents.It is almost nonvolatile. It is relatively stable in acidic and neutral media but hydrolyses under alkaline conditions.
Diflubenzuron is difficult to be degraded in sterilized water under neutral or acidic conditions. However, it is degraded rapidly under field conditions. Application of diflubenzuron to water resulted rapid partition to sediment; the parent compound and 4-chlorophenylurea (CPU) may persist on sediment for more than 30 days.
The rate of degradation of diflubenzuron in soil is strongly dependent on the particle size. For larger particles (10 microns), the half-life is 8–16 weeks and for smaller particles (2 microns), it is 0.5–1 week. Almost all of the parent compound breaks down to form 2,6-difluorobenzoic acid (DFBA) and CPU. A very minor amount forms 4-chloroaniline (PCA) which rapidly binds to the soil. Under field conditions, diflubenzuron has very low mobility.
Very little diflubenzuron is absorbed, metabolized, or translocated in plants. It also is not readily taken up from treated soil.
Diflubenzuron has very low vapor pressure (<2×10-7 Pa at 25°C) and its atmospheric half-life is only several hours. Therefore, it is not expected that diflubenzuron will be present in air for extended periods and the long-range transport and redeposition of diflubenzuron is expected to be negligible.

Diflubenzuron Preparation Products And Raw materials

Raw materials

2,6-Dichlorobenzonitrile 2,6-Difluorobenzamide 4-Chlorophenyl isocyanate Chlorfluazuron 4-Chloroaniline 2,6-Difluorobenzonitrile

Preparation Products

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Diflubenzuron Suppliers

Canada 2 China 284 Europe 2 France 2 Germany 2 India 5 Japan 3 South Korea 1 Spain 1 Switzerland 1 United Kingdom 8 United States 26 Global 337
TargetMol Chemicals Inc.
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View Lastest Price from Diflubenzuron manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Diflubenzuron 35367-38-5
Price
US $120.00-65.00/kg
Min. Order
1kg
Purity
97%
Supply Ability
20MT
Release date
2024-04-17
Hebei Yanxi Chemical Co., Ltd.
Product
Diflubenzuron 35367-38-5
Price
US $200.00/Kg/Drum
Min. Order
1KG
Purity
97%;98%
Supply Ability
20tons/month
Release date
2020-09-01
Hebei Chuanghai Biotechnology Co,.LTD
Product
Tc Diflubenzuron 35367-38-5
Price
US $10.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2024-08-20

35367-38-5, DiflubenzuronRelated Search:

Betaine Chlorodimethylphenylsilane Urea formaldehyde tert-Butylchlorodiphenylsilane CHLORPROPAMIDE Forchlorfenuron ALTRENOGEST Triphenylmethyl Chloride Teflubenzuron Glycine Pyrethrins Florfenicol CHLOROPHENYLSILANE 97 Chlorfluazuron Hexaflumuron (2-FLUOROBENZYL)METHYLAMINE 2,6-Difluorobenzylamine (2,6-Difluoro-benzyl)-urea

  • Diflubenzuron suspensoid (20%)
  • Diflubenzuron E.C.
  • Diflubenzuron 250mg [35367-38-5]
  • OMS 1804
  • oms1804
  • PDD 6040-I
  • pdd6040i
  • PH 60-40
  • ph-6040
  • PH60-40
  • philips-dupharph60-40
  • TH 60 40
  • th6040
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  • DIMILAN
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  • Dimilin(Solvay Duphar B.V.)
  • PDD60-40 I (Duphar B.V.)
  • TH6040(T.H.Agriculture & Nutrition Co.Inc.)
  • 1-(4-Chlorophenyl)-3-(2,6-difluorobenzyl)urea 95% [Diflubenzuron]
  • DIFLUBENZURON, 1GM, NEAT
  • DIFLUBENZURON PESTANAL (1-(4-CHLORO-PHEN
  • 1-(4-Chlorophenyl)-3-(2,6-difluoroBenzyl)urea[DifluBenzuron]
  • Diflubenzuron (Dimilin)
  • Difubenzuron
  • N-{[(4-Chlorophenol)amino]carbonyl]-2,6-difluorobenzamide
  • Pyrethroid urea
  • Difluorourea
  • Cholesterol Impurity 10
  • iflubenzuron
  • 1-(4-Chlorophenyl)-3-(2,6-difluorobenzoyl)urea (diflubenzuron)
  • 1-(p-chlorophenyl)-3-(2,6-difluorobenzoyl)-ure
  • 1-(p-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
  • astonex
  • Benzamide, N-[[(4-chlorophenyl)amino]carbonyl]-2,6-difluoro-
  • benzamide,N-[[(4-chlorophenyl)amino]carbonyl]-2,6-difluoro-
  • difluoron
  • Difluron
  • dimiling1
  • dimiling4
  • dimilinodc-45
  • dimilinwp-25
  • DU 112307
  • du112307
  • Duphacid
  • ent29054
  • ENT-29054
  • Largon
  • larvakil
  • n-(((4-chlorophenyl)amino)carbonyl)-2,6-difluoro-benzamid
  • n-((4-chlorophenyl)amino)-2,6-difluorobenzamide
  • N-(4-Chlorophenyl)-N'-(2,6-difluorobenzoyl)urea
  • n-[[(4-chlorophenyl)amino]carbonyl]-2,6-difluoro-benzamid
  • N-[[(4-Chlorophenyl)amno]carbonyl]-2,6-difluorobenzamide
  • th60-40
  • Thompson-Hayward 6040
  • thompsonhayward6040